Effects of connexin modulators in animal models of retinal degeneration : delivery and treatment efficacy
Worldwide, age-related macular degeneration (AMD) is one of the most frequently ocurring diseases associated with blindness. Previous studies have provided evidence for the role of inflammation and oxidative stress in AMD progression. 11 has also been found that connexin hemichannels playa role in t...
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| Format: | Thesis Book |
| Language: | English |
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Table of Contents:
- 1. Understanding intercellular interaction-exploring drug delivery and outcome benefits for ocular disease
- 2. Materials and methods
- 3. Effect of connexin43 mimetic peptide on acude photo-damage of the chorio-retinal complex
- 4. Effects of connexin43 mimetic peptide loaded nanoparticles on reducing acute photo-damage of the chorio-retinal complex
- 5. Efficacy to tonabersat in reducing acute photo-damage of the chorioretinal complex in the light damaged animal model
- 6. Tonabersat and probenecid protect from acute photo-damaged of the chorio-retinal complex in the light damaged animal model
- 7. Funtional, morphological and histopathological characterization of spontaneous diabetics rats and the outcome of connexin modulation
- 8. Discussion and conclusion