Assessment of Apolipoprotien E and Paraoxonase 1 192Q/R gene polymorphisms in hypertension /
Hypertension is a chronic cardiovascular disease that affects 43% of the Malaysian adult population. Hypertension is associated with significantly high morbidity and mortality rates. The exact cause of hypertension is still unknown but it is believed that hypertension occurs from complex interaction...
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| Main Author: | |
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| Format: | Thesis |
| Language: | English |
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Kuantan:
Kulliyyah of Medicine, International Islamic University Malaysia,
2011
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| Subjects: | |
| Online Access: | Click here to view 1st 24 pages of the thesis. Members can view fulltext at the specified PCs in the library. |
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| Summary: | Hypertension is a chronic cardiovascular disease that affects 43% of the Malaysian adult population. Hypertension is associated with significantly high morbidity and mortality rates. The exact cause of hypertension is still unknown but it is believed that hypertension occurs from complex interactions between multiple environmental and genetic factors. Although much is known about the environmental factors that predispose individuals to hypertension but the molecular mechanisms behind hypertension are still poorly understood. Between 30 and 60% of blood pressure variations are determined by genetic factors. A wide spectrum of genes has been studied for their possible role in the pathogenesis of hypertension, however very few genes have shown significant role in hypertension. Numerous recent studies on apoE and PON-1 proteins have shown that both proteins exhibit an anti atherosclerotic and antioxidant roles in the human body. Polymorphisms within the genes encoding these proteins have been linked with various pathologies including cardiovascular diseases, cognitive and infectious diseases. Apolipoprotein E (Apo E) is a plasma protein responsible for plasma clearance of triglyceride and cholesterol-rich lipoproteins. The 2, 3 and 4 are the three common alleles of this gene. Paraoxonase-1 (PON-1) is an HDL associated esterase enzyme that inhibits LDL oxidation. One of the most important polymorphisms within this gene is the codon 192. This case control study consisted of 143 participants (seventy hypertensive and seventy three controls).The aim of this study was to assess the association of apolipoprotein E and PON-1 192 gene polymorphisms with hypertension and level of blood pressure. ApoE and PON-1 192 gene polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism assay. The findings of this study suggest that polymorphisms in apoE and PON-1 192 were unlikely to confer genetic susceptibility for hypertension in our population samples. |
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| Item Description: | Abstract in English and Arabic. "A dissertation submitted in fulfilment of the requirement for the degree of Master of Medical Sciences."--On t.p. |
| Physical Description: | xvi, 123 leaves : ill. ; 30cm. |
| Bibliography: | Includes bibliographical references (leaves 93-110). |