Skin microvasculature in different types of diabetic foot ulcer : a comparative study /
Morphological changes affecting endothelial cells of skin microvasculature in diabetic foot ulcer (DFU) may indicate microcirculatory dysfunction and subsequently leads to poor healing of ulcer. In this study, I have analysed 42 subjects, involving 10 controls, 16 patients with neuropathic DFU and 1...
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
Kuantan :
Kulliyyah of Medicine, International Islamic University Malaysia,
2013
|
| Subjects: | |
| Online Access: | Click here to view 1st 24 pages of the thesis. Members can view fulltext at the specified PCs in the library. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| LEADER | 029130000a22002770004500 | ||
|---|---|---|---|
| 008 | 130715t2013 my ad g m 000 0 eng d | ||
| 040 | |a UIAM |b eng | ||
| 041 | |a eng | ||
| 043 | |a a-my--- | ||
| 050 | |a RD563 | ||
| 100 | 1 | |a Hazulin Mohd Radzuan | |
| 245 | 1 | |a Skin microvasculature in different types of diabetic foot ulcer : |b a comparative study / |c by Hazulin Mohd Radzuan | |
| 260 | |a Kuantan : |b Kulliyyah of Medicine, International Islamic University Malaysia, |c 2013 | ||
| 300 | |a xvii, 97 leaves : |b ill. ; |c 30cm. | ||
| 502 | |a Thesis (MMDSc)--International Islamic University Malaysia, 2013. | ||
| 504 | |a Includes bibliographical references (leaves 82-92). | ||
| 520 | |a Morphological changes affecting endothelial cells of skin microvasculature in diabetic foot ulcer (DFU) may indicate microcirculatory dysfunction and subsequently leads to poor healing of ulcer. In this study, I have analysed 42 subjects, involving 10 controls, 16 patients with neuropathic DFU and 16 patients with neuroischaemic DFU. The specimens were taken by using skin punch biopsy and routinely processed for light microscopy. I have calculated and measured the mean endothelial cell count (ECC), endothelial cell thickness (ECT) and luminal area:outer vessel area ratio in percentage (LA) from 3 selected arterioles and capillaries in each slide of every patient. There were significant decrement in ECC and LA among the diseased group as compared to the controls, F (2, 39) = 9.20, p = 0.01 and F (2, 39) = 17.54, p < 0.05. While the ECT of the diseased group were significantly higher than the controls, F (2, 39) = 66.11, p < 0.05. The Tukey post-hoc comparisons indicate that the ECC between neuropathic and neuroischemic group was insignificant, but the ECT and LA revealed significant differences as p < 0.05. In conclusion, the decrement of ECC and LA, and the increment of ECT among different types of DFU patients show endothelial cells adaptation towards diabetic state, thus affecting the patency of skin microvasculature and may signify different prognosis in different types of DFU. | ||
| 596 | |a 1 6 | ||
| 655 | 7 | |a Theses, IIUM local | |
| 690 | |a Dissertations, Academic |x Department of Basic Medical Sciences |z IIUM | ||
| 710 | 2 | |a International Islamic University Malaysia. |b Department of Basic Medical Sciences | |
| 856 | 4 | |u https://lib.iium.edu.my/mom/services/mom/document/getFile/nBWrZfqngSjObSimz5PLkksh7Oypx1c720131107110823486 |z Click here to view 1st 24 pages of the thesis. Members can view fulltext at the specified PCs in the library. | |
| 900 | |a hab-zhmn | ||
| 999 | |c 438518 |d 470172 | ||
| 952 | |0 0 |6 T RD 000563 H000431S 002013 |7 0 |8 THESES |9 759028 |a KIMC |b KIMC |c CLOSEACCES |g 0.00 |o t RD 563 H431S 2013 |p 00011288999 |r 2019-09-04 |t 1 |v 0.00 |y THESIS | ||
| 952 | |0 0 |6 TS CDF RD 000563 H000431S 002013 |7 0 |8 THESES |9 851101 |a IIUM |b IIUM |c MULTIMEDIA |g 0.00 |o ts cdf RD 563 H431S 2013 |p 00011289000 |r 2017-10-26 |t 1 |v 0.00 |y THESISDIG | ||