Determination of acetaminophen compound from aquilaria sp. leaves by hydrodistillation and its antimicrobial activity on e. coli / Siti Khairun Nissa' Afiffudden

Aquilaria sp. is known for its valuable agarwood. Determination of acetaminophen compound from Aquilaria leaves would increases the potential of an alternative drug to replace the synthetic drugs as the leaves become waste although the trees rich in medicinal benefits. Aquilaria malaccencis, Aquilar...

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Main Author:	Afiffudden, Siti Khairun Nissa'
Format:	Thesis
Language:	English
Published:	2017
Subjects:	Aromatic compounds Extraction
Online Access:	https://ir.uitm.edu.my/id/eprint/103111/1/103111.PDF
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id	my-uitm-ir.103111
record_format	uketd_dc
spelling	my-uitm-ir.1031112024-11-11T06:41:59Z Determination of acetaminophen compound from aquilaria sp. leaves by hydrodistillation and its antimicrobial activity on e. coli / Siti Khairun Nissa' Afiffudden 2017-04 Afiffudden, Siti Khairun Nissa' Aromatic compounds Extraction Aquilaria sp. is known for its valuable agarwood. Determination of acetaminophen compound from Aquilaria leaves would increases the potential of an alternative drug to replace the synthetic drugs as the leaves become waste although the trees rich in medicinal benefits. Aquilaria malaccencis, Aquilaria subintegra and Aquilaria crassna were chosen as the subject. The objectives of this study are to study the chemical structure in the leaves extract of each species by using Fourier Transform Infrared Spectroscopy (FTIR.) and to determine highest acetaminophen compound within a range of drying temperature (30, 40, 50, 60, 70 °C) through hydrodistiUation in the leaves by High Performance Liquid Chromatography (HPLC). Besides that, the antimicrobial activity of acetaminophen extracted towards E.coli is also being studied. In the characterization study, the similar compounds found in both synthetic acetaminophen and in the leaves extract. Drying at 60 °C promotes the highest extraction of acetaminophen for each three species. Meanwhile, the highest acetaminophen extracted were from Aquilaria crassna leaves with 81.36 ug/g of acetaminophen whereas 44.15 and 24.64 ug/g were extracted from Aquilaria subintegra and Aquilaria malaccencis respectively. The leaves extract with the highest acetaminophen concentration for each species involved in antimicrobial activity. Aquilaria crassna leaves extract showed a significant inhibition by agar spreading method at dilution of 109 cfu/mL. The numbers of colonies significantly reduced to 81 cfu/mL. Therefore, all three species of Aquilaria leaves extract contained acetaminophen compound, which deliberately may contribute to antipyretic activity and has inhibition effect in growth of E.coli. 2017-04 Thesis https://ir.uitm.edu.my/id/eprint/103111/ https://ir.uitm.edu.my/id/eprint/103111/1/103111.PDF text en public masters Universiti Teknologi MARA Faculty of Chemical Engineering
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Aromatic compounds Extraction
spellingShingle	Aromatic compounds Extraction Afiffudden, Siti Khairun Nissa' Determination of acetaminophen compound from aquilaria sp. leaves by hydrodistillation and its antimicrobial activity on e. coli / Siti Khairun Nissa' Afiffudden
description	Aquilaria sp. is known for its valuable agarwood. Determination of acetaminophen compound from Aquilaria leaves would increases the potential of an alternative drug to replace the synthetic drugs as the leaves become waste although the trees rich in medicinal benefits. Aquilaria malaccencis, Aquilaria subintegra and Aquilaria crassna were chosen as the subject. The objectives of this study are to study the chemical structure in the leaves extract of each species by using Fourier Transform Infrared Spectroscopy (FTIR.) and to determine highest acetaminophen compound within a range of drying temperature (30, 40, 50, 60, 70 °C) through hydrodistiUation in the leaves by High Performance Liquid Chromatography (HPLC). Besides that, the antimicrobial activity of acetaminophen extracted towards E.coli is also being studied. In the characterization study, the similar compounds found in both synthetic acetaminophen and in the leaves extract. Drying at 60 °C promotes the highest extraction of acetaminophen for each three species. Meanwhile, the highest acetaminophen extracted were from Aquilaria crassna leaves with 81.36 ug/g of acetaminophen whereas 44.15 and 24.64 ug/g were extracted from Aquilaria subintegra and Aquilaria malaccencis respectively. The leaves extract with the highest acetaminophen concentration for each species involved in antimicrobial activity. Aquilaria crassna leaves extract showed a significant inhibition by agar spreading method at dilution of 109 cfu/mL. The numbers of colonies significantly reduced to 81 cfu/mL. Therefore, all three species of Aquilaria leaves extract contained acetaminophen compound, which deliberately may contribute to antipyretic activity and has inhibition effect in growth of E.coli.
format	Thesis
qualification_level	Master's degree
author	Afiffudden, Siti Khairun Nissa'
author_facet	Afiffudden, Siti Khairun Nissa'
author_sort	Afiffudden, Siti Khairun Nissa'
title	Determination of acetaminophen compound from aquilaria sp. leaves by hydrodistillation and its antimicrobial activity on e. coli / Siti Khairun Nissa' Afiffudden
title_short	Determination of acetaminophen compound from aquilaria sp. leaves by hydrodistillation and its antimicrobial activity on e. coli / Siti Khairun Nissa' Afiffudden
title_full	Determination of acetaminophen compound from aquilaria sp. leaves by hydrodistillation and its antimicrobial activity on e. coli / Siti Khairun Nissa' Afiffudden
title_fullStr	Determination of acetaminophen compound from aquilaria sp. leaves by hydrodistillation and its antimicrobial activity on e. coli / Siti Khairun Nissa' Afiffudden
title_full_unstemmed	Determination of acetaminophen compound from aquilaria sp. leaves by hydrodistillation and its antimicrobial activity on e. coli / Siti Khairun Nissa' Afiffudden
title_sort	determination of acetaminophen compound from aquilaria sp. leaves by hydrodistillation and its antimicrobial activity on e. coli / siti khairun nissa' afiffudden
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Chemical Engineering
publishDate	2017
url	https://ir.uitm.edu.my/id/eprint/103111/1/103111.PDF
_version_	1818588079090302976

Determination of acetaminophen compound from aquilaria sp. leaves by hydrodistillation and its antimicrobial activity on e. coli / Siti Khairun Nissa' Afiffudden

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