Male juvenile rats gene expression in sexually dimorphic brain region after exposure to Bisphenol A (BPA) / Nur Ezzati A. Rahman
In higher vertebrates, estrogen can exert an organizational effect on sexually dimorphic areas of the central nervous system (CNS) during postnatal phase of development. The possibility that estrogenic pollutants may mimic estrogen action on the CNS during development and produce long- lasting or ir...
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| Format: | Thesis |
| Language: | English |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ir.uitm.edu.my/id/eprint/105119/1/105119.PDF |
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| Summary: | In higher vertebrates, estrogen can exert an organizational effect on sexually dimorphic areas of the central nervous system (CNS) during postnatal phase of development. The possibility that estrogenic pollutants may mimic estrogen action on the CNS during development and produce long- lasting or irreversible effects is an issue of great concern. Bisphenol A (BPA), which is commonly ingested by humans, is one of the estrogenic pollutants. This study determined the potential effect of BP A 100 mg/kg/day in a model of male juvenile Sprague-Dawley rats. In order to evaluate this effect, the male juvenile Sprague-Dawley rats have been fed orally with BP A 100 mg/kg/day, in different periods of time which are 7 days, 14 days and 28 days. Ethinyl estradiol 10 µg/kg bw was used as the positive control. The body weight and brain weight of male juvenile Sprague-Dawley rats, which were treated with BP A 100 mg/kg/day are increased drastically as the day of treatment increase, when compared to positive control. These findings showed that postnatal BPA exposure for a long period of time may alter the body weight and brain weight significantly. |
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