Investigation on contact angle during hydrotropic solubilization of the drug ketoconazole and griseofulvin / Norazura Che Hamid
The aqueous solubility of drug is often a limiting factor while developing the most desirable dosage form. Among the several techniques of solubility enhancement, hydrotropic solubilization is considered as one of the safest method. Many work highlighted the effect of solubility enhancers in improvi...
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| Main Author: | |
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| Format: | Thesis |
| Language: | English |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ir.uitm.edu.my/id/eprint/105206/1/105206.PDF |
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| Summary: | The aqueous solubility of drug is often a limiting factor while developing the most desirable dosage form. Among the several techniques of solubility enhancement, hydrotropic solubilization is considered as one of the safest method. Many work highlighted the effect of solubility enhancers in improving solubility of the drug, but no detailed explanation about the molecular processes during the improving phenomenon. The present study deals with experiments so to highlight solute solvent interaction and related modifications in case of the presence of hydrotropic agents. Contact angle was carried out in order to obtain valuable information regarding the solute solvent interactions. |
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