The effect of preparation parameters on the ibuprofen-PLGA microparticles using spray drying method / Noor Izzana Abd Razak

Spray drying method is one of technique that can be used to prepare Ibuprofen-poly (lactide-co-glycolide) (PLGA) microparticles. However, suitable and appropriate parameters are needed to prepare these microparticles that conform to optimal morphology, size distribution and yield to provide better a...

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Main Author:	Abd Razak, Noor Izzana
Format:	Thesis
Language:	English
Published:	2009
Subjects:	Pharmaceutical dosage forms Pharmaceutical chemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/105214/1/105214.PDF
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id	my-uitm-ir.105214
record_format	uketd_dc
spelling	my-uitm-ir.1052142024-12-05T09:06:42Z The effect of preparation parameters on the ibuprofen-PLGA microparticles using spray drying method / Noor Izzana Abd Razak 2009 Abd Razak, Noor Izzana Pharmaceutical dosage forms Pharmaceutical chemistry Spray drying method is one of technique that can be used to prepare Ibuprofen-poly (lactide-co-glycolide) (PLGA) microparticles. However, suitable and appropriate parameters are needed to prepare these microparticles that conform to optimal morphology, size distribution and yield to provide better and satisfied results upon characterization study. In this study, the effect of manipulating operating temperature of spray dryer or also known as the inlet temperature of a spray dryer towards microparticle shape, size and yield were investigated. lbuprofen-PLGA microparticles were prepared by spray drying process under varying operating temperature of 37 °C, 45 °C, 55 °C and 67 °C. The other process parameters like feed rate, spray gas flow, sample concentration and organic solvent used are being standardized and constant. Microparticles produced are being observed under Compound Research Polarizing Microscope for determination of shape and size. Most of microparticles observed under microscope were in spherical shape when operated under 45 °C. The yield is derived from calculation from equation based on weight. The yield of microparticles prepared by spray drying process was very low, and the highest yield was obtained when operating under 67 °C. Meanwhile smallest size range of microparticles was obtained when the operating or inlet temperature was set at 45 °C. The results thus revealed that optimal shape and size distribution for spray drying process was achieved under operating temperature of 45 °C despite the unsatisfactory yield. 2009 Thesis https://ir.uitm.edu.my/id/eprint/105214/ https://ir.uitm.edu.my/id/eprint/105214/1/105214.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Sameni, Javad Khadem
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Sameni, Javad Khadem
topic	Pharmaceutical dosage forms Pharmaceutical chemistry
spellingShingle	Pharmaceutical dosage forms Pharmaceutical chemistry Abd Razak, Noor Izzana The effect of preparation parameters on the ibuprofen-PLGA microparticles using spray drying method / Noor Izzana Abd Razak
description	Spray drying method is one of technique that can be used to prepare Ibuprofen-poly (lactide-co-glycolide) (PLGA) microparticles. However, suitable and appropriate parameters are needed to prepare these microparticles that conform to optimal morphology, size distribution and yield to provide better and satisfied results upon characterization study. In this study, the effect of manipulating operating temperature of spray dryer or also known as the inlet temperature of a spray dryer towards microparticle shape, size and yield were investigated. lbuprofen-PLGA microparticles were prepared by spray drying process under varying operating temperature of 37 °C, 45 °C, 55 °C and 67 °C. The other process parameters like feed rate, spray gas flow, sample concentration and organic solvent used are being standardized and constant. Microparticles produced are being observed under Compound Research Polarizing Microscope for determination of shape and size. Most of microparticles observed under microscope were in spherical shape when operated under 45 °C. The yield is derived from calculation from equation based on weight. The yield of microparticles prepared by spray drying process was very low, and the highest yield was obtained when operating under 67 °C. Meanwhile smallest size range of microparticles was obtained when the operating or inlet temperature was set at 45 °C. The results thus revealed that optimal shape and size distribution for spray drying process was achieved under operating temperature of 45 °C despite the unsatisfactory yield.
format	Thesis
qualification_level	Bachelor degree
author	Abd Razak, Noor Izzana
author_facet	Abd Razak, Noor Izzana
author_sort	Abd Razak, Noor Izzana
title	The effect of preparation parameters on the ibuprofen-PLGA microparticles using spray drying method / Noor Izzana Abd Razak
title_short	The effect of preparation parameters on the ibuprofen-PLGA microparticles using spray drying method / Noor Izzana Abd Razak
title_full	The effect of preparation parameters on the ibuprofen-PLGA microparticles using spray drying method / Noor Izzana Abd Razak
title_fullStr	The effect of preparation parameters on the ibuprofen-PLGA microparticles using spray drying method / Noor Izzana Abd Razak
title_full_unstemmed	The effect of preparation parameters on the ibuprofen-PLGA microparticles using spray drying method / Noor Izzana Abd Razak
title_sort	effect of preparation parameters on the ibuprofen-plga microparticles using spray drying method / noor izzana abd razak
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2009
url	https://ir.uitm.edu.my/id/eprint/105214/1/105214.PDF
_version_	1818588140262129664

The effect of preparation parameters on the ibuprofen-PLGA microparticles using spray drying method / Noor Izzana Abd Razak

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