In silico identification of plasmodium falciparum merozoite membrane proteins: a study of malaria vaccinology / Siti Badariah Baharin

Malaria is a serious infectious disease that has contributes to high rate of mortality throughout the world. It is spread by Anopheles mosquitoes, which have been prior infected by Plasmodium parasites such as Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae. The cu...

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Main Author:	Baharin, Siti Badariah
Format:	Thesis
Language:	English
Published:	2009
Subjects:	Pharmaceutical industry Pharmaceutical chemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/105347/1/105347.PDF
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id	my-uitm-ir.105347
record_format	uketd_dc
spelling	my-uitm-ir.1053472024-12-05T08:54:05Z In silico identification of plasmodium falciparum merozoite membrane proteins: a study of malaria vaccinology / Siti Badariah Baharin 2009 Baharin, Siti Badariah Pharmaceutical industry Pharmaceutical chemistry Malaria is a serious infectious disease that has contributes to high rate of mortality throughout the world. It is spread by Anopheles mosquitoes, which have been prior infected by Plasmodium parasites such as Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae. The current scenarios of malaria are that the antimalarial drugs cannot provide sufficient treatment, and the vaccines available also could not give full protection. Therefore, this study is aim at using in silica software to analyze protein sequence whether it could be a candidate to produce an effective vaccine. The analysis of the Pf7 protein sequence of Plasmodium falciparum shows that this protein consists of 264 amino acids, with grand average ofhydropathicity (ORA VY) value of -0.824. The negative value indicates that this protein is hydrophilic. This protein is located extracellularly and secondary structure prediction shows that it consists of 46.8% coil, 23.8% sheet, 19.0% turns, and 16.9% helix. For antigen epitope prediction, the result shows that subsequence "FFIFVTFNf' has high probability as promiscuous binder. As the conclusion, results obtained from all of the analyses conducted for this Pf7 protein can act as preliminary information in designing actual candidate vaccine in the future. 2009 Thesis https://ir.uitm.edu.my/id/eprint/105347/ https://ir.uitm.edu.my/id/eprint/105347/1/105347.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Pharmaceutical industry Pharmaceutical chemistry
spellingShingle	Pharmaceutical industry Pharmaceutical chemistry Baharin, Siti Badariah In silico identification of plasmodium falciparum merozoite membrane proteins: a study of malaria vaccinology / Siti Badariah Baharin
description	Malaria is a serious infectious disease that has contributes to high rate of mortality throughout the world. It is spread by Anopheles mosquitoes, which have been prior infected by Plasmodium parasites such as Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae. The current scenarios of malaria are that the antimalarial drugs cannot provide sufficient treatment, and the vaccines available also could not give full protection. Therefore, this study is aim at using in silica software to analyze protein sequence whether it could be a candidate to produce an effective vaccine. The analysis of the Pf7 protein sequence of Plasmodium falciparum shows that this protein consists of 264 amino acids, with grand average ofhydropathicity (ORA VY) value of -0.824. The negative value indicates that this protein is hydrophilic. This protein is located extracellularly and secondary structure prediction shows that it consists of 46.8% coil, 23.8% sheet, 19.0% turns, and 16.9% helix. For antigen epitope prediction, the result shows that subsequence "FFIFVTFNf' has high probability as promiscuous binder. As the conclusion, results obtained from all of the analyses conducted for this Pf7 protein can act as preliminary information in designing actual candidate vaccine in the future.
format	Thesis
qualification_level	Bachelor degree
author	Baharin, Siti Badariah
author_facet	Baharin, Siti Badariah
author_sort	Baharin, Siti Badariah
title	In silico identification of plasmodium falciparum merozoite membrane proteins: a study of malaria vaccinology / Siti Badariah Baharin
title_short	In silico identification of plasmodium falciparum merozoite membrane proteins: a study of malaria vaccinology / Siti Badariah Baharin
title_full	In silico identification of plasmodium falciparum merozoite membrane proteins: a study of malaria vaccinology / Siti Badariah Baharin
title_fullStr	In silico identification of plasmodium falciparum merozoite membrane proteins: a study of malaria vaccinology / Siti Badariah Baharin
title_full_unstemmed	In silico identification of plasmodium falciparum merozoite membrane proteins: a study of malaria vaccinology / Siti Badariah Baharin
title_sort	in silico identification of plasmodium falciparum merozoite membrane proteins: a study of malaria vaccinology / siti badariah baharin
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2009
url	https://ir.uitm.edu.my/id/eprint/105347/1/105347.PDF
_version_	1818588146566168576

In silico identification of plasmodium falciparum merozoite membrane proteins: a study of malaria vaccinology / Siti Badariah Baharin

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