Antiproliferative properties of chloroform extract of dicranopteris linearis leaves against selected cancer cell lines / Mohamad Yazid Mohamad Noh
The in vitro antiproliferative and chloroform extract Dicranopteris linearis and its fractions leaves were determined in the present study by using the 3,(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) assay. The chloroform extract of D. linearis exhibited inhibition of cell prolif...
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| Format: | Thesis |
| Language: | English |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ir.uitm.edu.my/id/eprint/105522/1/105522.PDF |
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| Summary: | The in vitro antiproliferative and chloroform extract Dicranopteris linearis and its fractions leaves were determined in the present study by using the 3,(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) assay. The chloroform extract of D. linearis exhibited inhibition of cell proliferation of HL-60 at concentration of 31.5 µg/ml but no anti proliferative activity detected when tested on A549 cells. Only DLF5was shown to be cytotoxic against HL-60 with IC50 value of 39.5 µg/ml while no fraction of D. linearis leaves seemed able to inhibite the proliferation of A549 cells. Interestingly, the extract and all fractions except DLF6 (IC50 = 4ug/mL) did not exhibit cytotoxic effects on 3T3 normal cells. In conclusion, the D. linearis leaves possessed potential anti-proliferative that could be attributed to its bioactive compounds within the leaves, thus, further study is needed to explore the lead compound liable for anti-proliferative activity from this plant. |
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