Antiproliferative properties of chloroform extract of dicranopteris linearis leaves against selected cancer cell lines / Mohamad Yazid Mohamad Noh

The in vitro antiproliferative and chloroform extract Dicranopteris linearis and its fractions leaves were determined in the present study by using the 3,(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) assay. The chloroform extract of D. linearis exhibited inhibition of cell prolif...

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Main Author:	Mohamad Noh, Mohamad Yazid
Format:	Thesis
Language:	English
Published:	2009
Subjects:	Pharmaceutical chemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/105522/1/105522.PDF
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id	my-uitm-ir.105522
record_format	uketd_dc
spelling	my-uitm-ir.1055222024-12-04T14:27:14Z Antiproliferative properties of chloroform extract of dicranopteris linearis leaves against selected cancer cell lines / Mohamad Yazid Mohamad Noh 2009 Mohamad Noh, Mohamad Yazid Pharmaceutical chemistry The in vitro antiproliferative and chloroform extract Dicranopteris linearis and its fractions leaves were determined in the present study by using the 3,(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) assay. The chloroform extract of D. linearis exhibited inhibition of cell proliferation of HL-60 at concentration of 31.5 µg/ml but no anti proliferative activity detected when tested on A549 cells. Only DLF5was shown to be cytotoxic against HL-60 with IC50 value of 39.5 µg/ml while no fraction of D. linearis leaves seemed able to inhibite the proliferation of A549 cells. Interestingly, the extract and all fractions except DLF6 (IC50 = 4ug/mL) did not exhibit cytotoxic effects on 3T3 normal cells. In conclusion, the D. linearis leaves possessed potential anti-proliferative that could be attributed to its bioactive compounds within the leaves, thus, further study is needed to explore the lead compound liable for anti-proliferative activity from this plant. 2009 Thesis https://ir.uitm.edu.my/id/eprint/105522/ https://ir.uitm.edu.my/id/eprint/105522/1/105522.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Zakaria, Zainul Amirudin
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Zakaria, Zainul Amirudin
topic	Pharmaceutical chemistry
spellingShingle	Pharmaceutical chemistry Mohamad Noh, Mohamad Yazid Antiproliferative properties of chloroform extract of dicranopteris linearis leaves against selected cancer cell lines / Mohamad Yazid Mohamad Noh
description	The in vitro antiproliferative and chloroform extract Dicranopteris linearis and its fractions leaves were determined in the present study by using the 3,(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) assay. The chloroform extract of D. linearis exhibited inhibition of cell proliferation of HL-60 at concentration of 31.5 µg/ml but no anti proliferative activity detected when tested on A549 cells. Only DLF5was shown to be cytotoxic against HL-60 with IC50 value of 39.5 µg/ml while no fraction of D. linearis leaves seemed able to inhibite the proliferation of A549 cells. Interestingly, the extract and all fractions except DLF6 (IC50 = 4ug/mL) did not exhibit cytotoxic effects on 3T3 normal cells. In conclusion, the D. linearis leaves possessed potential anti-proliferative that could be attributed to its bioactive compounds within the leaves, thus, further study is needed to explore the lead compound liable for anti-proliferative activity from this plant.
format	Thesis
qualification_level	Bachelor degree
author	Mohamad Noh, Mohamad Yazid
author_facet	Mohamad Noh, Mohamad Yazid
author_sort	Mohamad Noh, Mohamad Yazid
title	Antiproliferative properties of chloroform extract of dicranopteris linearis leaves against selected cancer cell lines / Mohamad Yazid Mohamad Noh
title_short	Antiproliferative properties of chloroform extract of dicranopteris linearis leaves against selected cancer cell lines / Mohamad Yazid Mohamad Noh
title_full	Antiproliferative properties of chloroform extract of dicranopteris linearis leaves against selected cancer cell lines / Mohamad Yazid Mohamad Noh
title_fullStr	Antiproliferative properties of chloroform extract of dicranopteris linearis leaves against selected cancer cell lines / Mohamad Yazid Mohamad Noh
title_full_unstemmed	Antiproliferative properties of chloroform extract of dicranopteris linearis leaves against selected cancer cell lines / Mohamad Yazid Mohamad Noh
title_sort	antiproliferative properties of chloroform extract of dicranopteris linearis leaves against selected cancer cell lines / mohamad yazid mohamad noh
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2009
url	https://ir.uitm.edu.my/id/eprint/105522/1/105522.PDF
_version_	1818588150350479360

Antiproliferative properties of chloroform extract of dicranopteris linearis leaves against selected cancer cell lines / Mohamad Yazid Mohamad Noh

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