Hormonal changes in male bisphenol-A treated spraguey dawley rats at different time response / Mazlieana Hidayah Abu Hassan Basri

The effects of Bisphenol-A (BPA) on hormonal changes in juvenile male Sprague Dawley (SD) rats at different time response (7, 14 and 28 days) of treatment was observed in this study from PND28-56. In this study nine groups were prepared for BPA, ethinyl estradiol (EE) and Tween-80 in distilled wate...

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Main Author:	Abu Hassan Basri, Mazlieana Hidayah
Format:	Thesis
Language:	English
Published:	2009
Subjects:	Pharmacognosy Pharmaceutical substances (Plant, animal, and inorganic)
Online Access:	https://ir.uitm.edu.my/id/eprint/105833/1/105833.PDF
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spelling	my-uitm-ir.1058332024-12-05T08:12:31Z Hormonal changes in male bisphenol-A treated spraguey dawley rats at different time response / Mazlieana Hidayah Abu Hassan Basri 2009 Abu Hassan Basri, Mazlieana Hidayah Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) The effects of Bisphenol-A (BPA) on hormonal changes in juvenile male Sprague Dawley (SD) rats at different time response (7, 14 and 28 days) of treatment was observed in this study from PND28-56. In this study nine groups were prepared for BPA, ethinyl estradiol (EE) and Tween-80 in distilled water (1:9 v/v) treatments on three different duration of time. Three groups of rats were administered orally with 100 mg/kg body weight of BPA. Another three groups of rats were administered orally with 100 mg/kg body weight of EE. Control group was administered with the vehicle of Tween- 80 with corn oil (1:9 v/v). The observations and analysis made in this study was the changes of the testosterone hormone levels for BPA, EE and control groups at 7, 14 and 28 days .. Statistical analysis by two-way ANOV A showed that treatments at different time response has significantly (p<0.05) influence the testosterone levels. Modifications in the circulating testosterone levels were observed after treatments. Testosterone was reduced in testosterone levels of the juveniles, both with BPA and EE compared to control groups. The level of testosterone concentration for BPA and EE groups were lower than negative control group while testosterone level for BPA group was lower than EE group. This can be due to the much higher estrogenic potency of EE; the potency of BPA is approximately 10 to 1000-fold less than that of EE. The testosterone levels were low for 7 days treatment (93.78 ± 14.51 pg/ml) and higher for 14 days treatment (159.91 ± 26.63 pg/ml) compared to 28 days treatment (149.84 ± 36.95 pg/ml). Statistical analysis by one-way ANOV A at p-value=0.05 shows there were no significance mean difference of testosterone levels between 7, 14 and 28 days treatment. Testosterone levels were significantly highest in negative control group (l 84.4638±35.79038 pg/ml), followed by positive control group (156.9857 ± 22.03493 pg/ml) and the lowest in BPA-treated group (62.0767±15.25640 pg/ml). There were significant differences of testosterone levels between BPA, EE and control groups. 2009 Thesis https://ir.uitm.edu.my/id/eprint/105833/ https://ir.uitm.edu.my/id/eprint/105833/1/105833.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Mohamed, Ruzianisra
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Mohamed, Ruzianisra
topic	Pharmacognosy Pharmaceutical substances (Plant, animal, and inorganic)
spellingShingle	Pharmacognosy Pharmaceutical substances (Plant, animal, and inorganic) Abu Hassan Basri, Mazlieana Hidayah Hormonal changes in male bisphenol-A treated spraguey dawley rats at different time response / Mazlieana Hidayah Abu Hassan Basri
description	The effects of Bisphenol-A (BPA) on hormonal changes in juvenile male Sprague Dawley (SD) rats at different time response (7, 14 and 28 days) of treatment was observed in this study from PND28-56. In this study nine groups were prepared for BPA, ethinyl estradiol (EE) and Tween-80 in distilled water (1:9 v/v) treatments on three different duration of time. Three groups of rats were administered orally with 100 mg/kg body weight of BPA. Another three groups of rats were administered orally with 100 mg/kg body weight of EE. Control group was administered with the vehicle of Tween- 80 with corn oil (1:9 v/v). The observations and analysis made in this study was the changes of the testosterone hormone levels for BPA, EE and control groups at 7, 14 and 28 days .. Statistical analysis by two-way ANOV A showed that treatments at different time response has significantly (p<0.05) influence the testosterone levels. Modifications in the circulating testosterone levels were observed after treatments. Testosterone was reduced in testosterone levels of the juveniles, both with BPA and EE compared to control groups. The level of testosterone concentration for BPA and EE groups were lower than negative control group while testosterone level for BPA group was lower than EE group. This can be due to the much higher estrogenic potency of EE; the potency of BPA is approximately 10 to 1000-fold less than that of EE. The testosterone levels were low for 7 days treatment (93.78 ± 14.51 pg/ml) and higher for 14 days treatment (159.91 ± 26.63 pg/ml) compared to 28 days treatment (149.84 ± 36.95 pg/ml). Statistical analysis by one-way ANOV A at p-value=0.05 shows there were no significance mean difference of testosterone levels between 7, 14 and 28 days treatment. Testosterone levels were significantly highest in negative control group (l 84.4638±35.79038 pg/ml), followed by positive control group (156.9857 ± 22.03493 pg/ml) and the lowest in BPA-treated group (62.0767±15.25640 pg/ml). There were significant differences of testosterone levels between BPA, EE and control groups.
format	Thesis
qualification_level	Bachelor degree
author	Abu Hassan Basri, Mazlieana Hidayah
author_facet	Abu Hassan Basri, Mazlieana Hidayah
author_sort	Abu Hassan Basri, Mazlieana Hidayah
title	Hormonal changes in male bisphenol-A treated spraguey dawley rats at different time response / Mazlieana Hidayah Abu Hassan Basri
title_short	Hormonal changes in male bisphenol-A treated spraguey dawley rats at different time response / Mazlieana Hidayah Abu Hassan Basri
title_full	Hormonal changes in male bisphenol-A treated spraguey dawley rats at different time response / Mazlieana Hidayah Abu Hassan Basri
title_fullStr	Hormonal changes in male bisphenol-A treated spraguey dawley rats at different time response / Mazlieana Hidayah Abu Hassan Basri
title_full_unstemmed	Hormonal changes in male bisphenol-A treated spraguey dawley rats at different time response / Mazlieana Hidayah Abu Hassan Basri
title_sort	hormonal changes in male bisphenol-a treated spraguey dawley rats at different time response / mazlieana hidayah abu hassan basri
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2009
url	https://ir.uitm.edu.my/id/eprint/105833/1/105833.PDF
_version_	1818588157375938560

Hormonal changes in male bisphenol-A treated spraguey dawley rats at different time response / Mazlieana Hidayah Abu Hassan Basri

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