Investigation of the solid dispersion of aqueous insoluble drug (griseofulvin) with polyethylene glycol (PEGs) by the means of NMR spectroscopy / Mohd Affendi Ismail

Poorly water-soluble drugs are associated with slow drug absorption leading eventually to inadequate and variable bioavailability. Nowadays, there are many approaches that have been developed to improve the solubility of drugs. Some of the examples are increasing the total surface area of the drug (...

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Main Author:	Ismail, Mohd Affendi
Format:	Thesis
Language:	English
Published:	2009
Subjects:	Pharmaceutical dosage forms Pharmaceutical chemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/105836/1/105836.PDF
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id	my-uitm-ir.105836
record_format	uketd_dc
spelling	my-uitm-ir.1058362024-12-05T08:12:29Z Investigation of the solid dispersion of aqueous insoluble drug (griseofulvin) with polyethylene glycol (PEGs) by the means of NMR spectroscopy / Mohd Affendi Ismail 2009 Ismail, Mohd Affendi Pharmaceutical dosage forms Pharmaceutical chemistry Poorly water-soluble drugs are associated with slow drug absorption leading eventually to inadequate and variable bioavailability. Nowadays, there are many approaches that have been developed to improve the solubility of drugs. Some of the examples are increasing the total surface area of the drug (surfactant), modification of crystal form of the drug, and the inclusion and complexation of the drug substance with the excipient. The incorporation of drugs into hydrophilic carrier has frequently been reported to increase the dissolution rate of poorly soluble drugs, often leading to improved drug bioavailability. Polyethylene glycols (PEGs) are water-soluble liquids or waxy solids used in cosmetic and pharmaceutical preparations and in the manufacturing of emulsifying or wetting agents and lubricants. Polyethylene glycol 400 (PEG 400) is a good example of a commonly used inert cosolvent that has wide application across several therapeutic areas for both oral and parenteral administration. PEGs can form a complex with aqueous insoluble drugs and interact well with water molecules; therefore in this study it could act as hydrotropic agent to enhance the solubility of aqueous insoluble griseofulvin. However, the molecular mechanism of hydrotropic solubilization has not yet been elucidated completely and studies have shown that hydrotropy differs from the micellar solubilization of hydrophobic substances in water by surfactant molecules. Therefore, the solid dispersion of aqueos insoluble griseofulvin with different concentrations of PEGs was done by the means of NMR spectroscopy to detect any chemical shifts, conformational changes and also more importantly to detect any increase in griseofulvin solubility and dissolution rate. 2009 Thesis https://ir.uitm.edu.my/id/eprint/105836/ https://ir.uitm.edu.my/id/eprint/105836/1/105836.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Ali Shah, Syed Adnan
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Ali Shah, Syed Adnan
topic	Pharmaceutical dosage forms Pharmaceutical chemistry
spellingShingle	Pharmaceutical dosage forms Pharmaceutical chemistry Ismail, Mohd Affendi Investigation of the solid dispersion of aqueous insoluble drug (griseofulvin) with polyethylene glycol (PEGs) by the means of NMR spectroscopy / Mohd Affendi Ismail
description	Poorly water-soluble drugs are associated with slow drug absorption leading eventually to inadequate and variable bioavailability. Nowadays, there are many approaches that have been developed to improve the solubility of drugs. Some of the examples are increasing the total surface area of the drug (surfactant), modification of crystal form of the drug, and the inclusion and complexation of the drug substance with the excipient. The incorporation of drugs into hydrophilic carrier has frequently been reported to increase the dissolution rate of poorly soluble drugs, often leading to improved drug bioavailability. Polyethylene glycols (PEGs) are water-soluble liquids or waxy solids used in cosmetic and pharmaceutical preparations and in the manufacturing of emulsifying or wetting agents and lubricants. Polyethylene glycol 400 (PEG 400) is a good example of a commonly used inert cosolvent that has wide application across several therapeutic areas for both oral and parenteral administration. PEGs can form a complex with aqueous insoluble drugs and interact well with water molecules; therefore in this study it could act as hydrotropic agent to enhance the solubility of aqueous insoluble griseofulvin. However, the molecular mechanism of hydrotropic solubilization has not yet been elucidated completely and studies have shown that hydrotropy differs from the micellar solubilization of hydrophobic substances in water by surfactant molecules. Therefore, the solid dispersion of aqueos insoluble griseofulvin with different concentrations of PEGs was done by the means of NMR spectroscopy to detect any chemical shifts, conformational changes and also more importantly to detect any increase in griseofulvin solubility and dissolution rate.
format	Thesis
qualification_level	Bachelor degree
author	Ismail, Mohd Affendi
author_facet	Ismail, Mohd Affendi
author_sort	Ismail, Mohd Affendi
title	Investigation of the solid dispersion of aqueous insoluble drug (griseofulvin) with polyethylene glycol (PEGs) by the means of NMR spectroscopy / Mohd Affendi Ismail
title_short	Investigation of the solid dispersion of aqueous insoluble drug (griseofulvin) with polyethylene glycol (PEGs) by the means of NMR spectroscopy / Mohd Affendi Ismail
title_full	Investigation of the solid dispersion of aqueous insoluble drug (griseofulvin) with polyethylene glycol (PEGs) by the means of NMR spectroscopy / Mohd Affendi Ismail
title_fullStr	Investigation of the solid dispersion of aqueous insoluble drug (griseofulvin) with polyethylene glycol (PEGs) by the means of NMR spectroscopy / Mohd Affendi Ismail
title_full_unstemmed	Investigation of the solid dispersion of aqueous insoluble drug (griseofulvin) with polyethylene glycol (PEGs) by the means of NMR spectroscopy / Mohd Affendi Ismail
title_sort	investigation of the solid dispersion of aqueous insoluble drug (griseofulvin) with polyethylene glycol (pegs) by the means of nmr spectroscopy / mohd affendi ismail
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2009
url	https://ir.uitm.edu.my/id/eprint/105836/1/105836.PDF
_version_	1818588157626548224

Investigation of the solid dispersion of aqueous insoluble drug (griseofulvin) with polyethylene glycol (PEGs) by the means of NMR spectroscopy / Mohd Affendi Ismail

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