Histological changes in male reproductive systems of time responses bisphenol A treated sprague dawley rats / Bob Iskandar Kadir

Bisphenol A (BPA) that is extensively used in food packaging industries is actually an estrogen-mimicking chemical that can bind to androgen receptors and inhibit the action of androgen. According to previous studies, BPA has been shown to have estrogenic activity and therefore, this study was desig...

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Main Author:	Kadir, Bob Iskandar
Format:	Thesis
Language:	English
Published:	2009
Subjects:	Pharmaceutical industry Pharmaceutical chemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/106324/1/106324.PDF
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id	my-uitm-ir.106324
record_format	uketd_dc
spelling	my-uitm-ir.1063242024-12-15T03:16:39Z Histological changes in male reproductive systems of time responses bisphenol A treated sprague dawley rats / Bob Iskandar Kadir 2009 Kadir, Bob Iskandar Pharmaceutical industry Pharmaceutical chemistry Bisphenol A (BPA) that is extensively used in food packaging industries is actually an estrogen-mimicking chemical that can bind to androgen receptors and inhibit the action of androgen. According to previous studies, BPA has been shown to have estrogenic activity and therefore, this study was designed to examine the time response effect of BPA on male reproductive system by using SD rats that had been exposed to BPA since juvenile age. BPA of lOOmg/kg body weight/ daily was forced-fed to SD rats for three different periods of 7 days, 14 days and 28 days. After each treatment, all the treated rats were sacrificed and the testes were removed and processed for histological analysis. The obtained result showed some histological changes in seminiferous tubules of testes in adult rats, such as loss of luminal space of the seminiferous tubules, accumulation of amorphous material in the tubes, reduction in the number of maturating spermatids and aberrant distribution of spermatogenic cells within the epithelium. In conclusion, the result obtained indicates that exposure or consumption of BPA since juvenile age might has profound effects on the tissue arrangement in testes as well as on the spermatogenesis. 2009 Thesis https://ir.uitm.edu.my/id/eprint/106324/ https://ir.uitm.edu.my/id/eprint/106324/1/106324.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Pharmaceutical industry Pharmaceutical chemistry
spellingShingle	Pharmaceutical industry Pharmaceutical chemistry Kadir, Bob Iskandar Histological changes in male reproductive systems of time responses bisphenol A treated sprague dawley rats / Bob Iskandar Kadir
description	Bisphenol A (BPA) that is extensively used in food packaging industries is actually an estrogen-mimicking chemical that can bind to androgen receptors and inhibit the action of androgen. According to previous studies, BPA has been shown to have estrogenic activity and therefore, this study was designed to examine the time response effect of BPA on male reproductive system by using SD rats that had been exposed to BPA since juvenile age. BPA of lOOmg/kg body weight/ daily was forced-fed to SD rats for three different periods of 7 days, 14 days and 28 days. After each treatment, all the treated rats were sacrificed and the testes were removed and processed for histological analysis. The obtained result showed some histological changes in seminiferous tubules of testes in adult rats, such as loss of luminal space of the seminiferous tubules, accumulation of amorphous material in the tubes, reduction in the number of maturating spermatids and aberrant distribution of spermatogenic cells within the epithelium. In conclusion, the result obtained indicates that exposure or consumption of BPA since juvenile age might has profound effects on the tissue arrangement in testes as well as on the spermatogenesis.
format	Thesis
qualification_level	Bachelor degree
author	Kadir, Bob Iskandar
author_facet	Kadir, Bob Iskandar
author_sort	Kadir, Bob Iskandar
title	Histological changes in male reproductive systems of time responses bisphenol A treated sprague dawley rats / Bob Iskandar Kadir
title_short	Histological changes in male reproductive systems of time responses bisphenol A treated sprague dawley rats / Bob Iskandar Kadir
title_full	Histological changes in male reproductive systems of time responses bisphenol A treated sprague dawley rats / Bob Iskandar Kadir
title_fullStr	Histological changes in male reproductive systems of time responses bisphenol A treated sprague dawley rats / Bob Iskandar Kadir
title_full_unstemmed	Histological changes in male reproductive systems of time responses bisphenol A treated sprague dawley rats / Bob Iskandar Kadir
title_sort	histological changes in male reproductive systems of time responses bisphenol a treated sprague dawley rats / bob iskandar kadir
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2009
url	https://ir.uitm.edu.my/id/eprint/106324/1/106324.PDF
_version_	1818588176239820800

Histological changes in male reproductive systems of time responses bisphenol A treated sprague dawley rats / Bob Iskandar Kadir

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