The effects of trans fat diet intake on metabolic parameters and DNA methylation profile in male offspring of in-utero BBA exposed rats / Hala F. S. Abulehia
Bisphenol A (BPA) is a plasticizer used in the manufacturing of many products, and its involvement in metabolic syndrome risk and development is still not fully understood. Exposure to BPA during critical windows such as pregnancy is known to affect the programming of metabolically active tissues in...
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2023
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my-uitm-ir.1068182024-12-04T14:27:38Z The effects of trans fat diet intake on metabolic parameters and DNA methylation profile in male offspring of in-utero BBA exposed rats / Hala F. S. Abulehia 2023 Abd Karim, Siti Fatma DNA. Deoxyribonucleic acids QP Physiology Bisphenol A (BPA) is a plasticizer used in the manufacturing of many products, and its involvement in metabolic syndrome risk and development is still not fully understood. Exposure to BPA during critical windows such as pregnancy is known to affect the programming of metabolically active tissues in offspring and increase susceptibility to adverse effects of excessive trans fat diet (TFD) intake. In this study, we aimed to investigate the effect of prenatal BPA exposure with postnatal TFD intake on metabolic and biochemical parameters, pancreatic tissue histology, peroxisome proliferator-activated receptor γ (PPARγ) protein expression, and global DNA methylation expression on adult SD rat offspring. Eighteen pregnant rats were divided into three groups: control (CTL), vehicle tween 80 (VHC), and BPA (5 mg/kg/day) from pregnancy day (PD) 2 to PD 21. Their male rats offspring were then fed either with normal diet (ND) or TFD from postnatal week (PNW) 3 to PNW 14 and were divided into six groups; ND control group (CTLND), TFD control group (CTLTFD), ND vehicle control group (VHCND), TFD vehicle control group (VHCTFD), ND BPA exposed group (BPAND) and TFD BPA exposed group (BPATFD). In offspring, the physiological parameters including body weight, waist circumference, water, and food intake were measured weekly. 2023 Thesis https://ir.uitm.edu.my/id/eprint/106818/ https://ir.uitm.edu.my/id/eprint/106818/2/106818.pdf text en public phd doctoral Universiti Teknologi MARA (UiTM) Faculty of Medicine Mohd Nor, Noor Shafina |
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Universiti Teknologi MARA |
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UiTM Institutional Repository |
| language |
English |
| advisor |
Mohd Nor, Noor Shafina |
| topic |
DNA Deoxyribonucleic acids QP Physiology |
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DNA Deoxyribonucleic acids QP Physiology Abd Karim, Siti Fatma The effects of trans fat diet intake on metabolic parameters and DNA methylation profile in male offspring of in-utero BBA exposed rats / Hala F. S. Abulehia |
| description |
Bisphenol A (BPA) is a plasticizer used in the manufacturing of many products, and its involvement in metabolic syndrome risk and development is still not fully understood. Exposure to BPA during critical windows such as pregnancy is known to affect the programming of metabolically active tissues in offspring and increase susceptibility to adverse effects of excessive trans fat diet (TFD) intake. In this study, we aimed to investigate the effect of prenatal BPA exposure with postnatal TFD intake on metabolic and biochemical parameters, pancreatic tissue histology, peroxisome proliferator-activated receptor γ (PPARγ) protein expression, and global DNA methylation expression on adult SD rat offspring. Eighteen pregnant rats were divided into three groups: control (CTL), vehicle tween 80 (VHC), and BPA (5 mg/kg/day) from pregnancy day (PD) 2 to PD 21. Their male rats offspring were then fed either with normal diet (ND) or TFD from postnatal week (PNW) 3 to PNW 14 and were divided into six groups; ND control group (CTLND), TFD control group (CTLTFD), ND vehicle control group (VHCND), TFD vehicle control group (VHCTFD), ND BPA exposed group (BPAND) and TFD BPA exposed group (BPATFD). In offspring, the physiological parameters including body weight, waist circumference, water, and food intake were measured weekly. |
| format |
Thesis |
| qualification_name |
Doctor of Philosophy (PhD.) |
| qualification_level |
Doctorate |
| author |
Abd Karim, Siti Fatma |
| author_facet |
Abd Karim, Siti Fatma |
| author_sort |
Abd Karim, Siti Fatma |
| title |
The effects of trans fat diet intake on metabolic parameters and DNA methylation profile in male offspring of in-utero BBA exposed rats / Hala F. S. Abulehia |
| title_short |
The effects of trans fat diet intake on metabolic parameters and DNA methylation profile in male offspring of in-utero BBA exposed rats / Hala F. S. Abulehia |
| title_full |
The effects of trans fat diet intake on metabolic parameters and DNA methylation profile in male offspring of in-utero BBA exposed rats / Hala F. S. Abulehia |
| title_fullStr |
The effects of trans fat diet intake on metabolic parameters and DNA methylation profile in male offspring of in-utero BBA exposed rats / Hala F. S. Abulehia |
| title_full_unstemmed |
The effects of trans fat diet intake on metabolic parameters and DNA methylation profile in male offspring of in-utero BBA exposed rats / Hala F. S. Abulehia |
| title_sort |
effects of trans fat diet intake on metabolic parameters and dna methylation profile in male offspring of in-utero bba exposed rats / hala f. s. abulehia |
| granting_institution |
Universiti Teknologi MARA (UiTM) |
| granting_department |
Faculty of Medicine |
| publishDate |
2023 |
| url |
https://ir.uitm.edu.my/id/eprint/106818/2/106818.pdf |
| _version_ |
1818588188516548608 |