Investigation on solubilisation behaviour of l-isoleucine polymorph and its associated thermodynamics properties / Vannessa Shallomy Darrell

The motivation to determine the relationship of thermodynamic behaviour (solubilities) and properties between L-isoleucine polymorphic forms grown in water and to understand the molecular interaction behaviour between the solute-solvent molecules at the molecular level between L-isoleucine and water...

Full description

Saved in:

Bibliographic Details
Main Author:	Darrell, Vannessa Shallomy
Format:	Thesis
Language:	English
Published:	2024
Subjects:	Supersaturated solutions Crystallization, etc.
Online Access:	https://ir.uitm.edu.my/id/eprint/107178/1/107178.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-uitm-ir.107178
record_format	uketd_dc
spelling	my-uitm-ir.1071782024-12-04T08:37:05Z Investigation on solubilisation behaviour of l-isoleucine polymorph and its associated thermodynamics properties / Vannessa Shallomy Darrell 2024 Darrell, Vannessa Shallomy Supersaturated solutions. Crystallization, etc. The motivation to determine the relationship of thermodynamic behaviour (solubilities) and properties between L-isoleucine polymorphic forms grown in water and to understand the molecular interaction behaviour between the solute-solvent molecules at the molecular level between L-isoleucine and water has been the reasons to establish this work. To achieve these objectives, the study of physico-chemical properties of Lisoleucine was carried out, i.e., through (1) isothermal and polythermal dissolution methods, (2) solid-state properties determination, and (3) molecular modelling for solubilisation prediction. The L-isoleucine polymorphic forms were recrystallised using isothermal and polythermal crystallisation techniques. The product crystals were analysed by means of x-ray powder diffraction, differential scanning calorimetry, fourier transform infrared, and an optical microscope to evaluate the form produced. The dried L-isoleucine crystals were then used as the feed for solubility determination experiments. 2024 Thesis https://ir.uitm.edu.my/id/eprint/107178/ https://ir.uitm.edu.my/id/eprint/107178/1/107178.pdf text en public masters Universiti Teknologi MARA (UiTM) College of Engineering
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Supersaturated solutions Crystallization, etc.
spellingShingle	Supersaturated solutions Crystallization, etc. Darrell, Vannessa Shallomy Investigation on solubilisation behaviour of l-isoleucine polymorph and its associated thermodynamics properties / Vannessa Shallomy Darrell
description	The motivation to determine the relationship of thermodynamic behaviour (solubilities) and properties between L-isoleucine polymorphic forms grown in water and to understand the molecular interaction behaviour between the solute-solvent molecules at the molecular level between L-isoleucine and water has been the reasons to establish this work. To achieve these objectives, the study of physico-chemical properties of Lisoleucine was carried out, i.e., through (1) isothermal and polythermal dissolution methods, (2) solid-state properties determination, and (3) molecular modelling for solubilisation prediction. The L-isoleucine polymorphic forms were recrystallised using isothermal and polythermal crystallisation techniques. The product crystals were analysed by means of x-ray powder diffraction, differential scanning calorimetry, fourier transform infrared, and an optical microscope to evaluate the form produced. The dried L-isoleucine crystals were then used as the feed for solubility determination experiments.
format	Thesis
qualification_level	Master's degree
author	Darrell, Vannessa Shallomy
author_facet	Darrell, Vannessa Shallomy
author_sort	Darrell, Vannessa Shallomy
title	Investigation on solubilisation behaviour of l-isoleucine polymorph and its associated thermodynamics properties / Vannessa Shallomy Darrell
title_short	Investigation on solubilisation behaviour of l-isoleucine polymorph and its associated thermodynamics properties / Vannessa Shallomy Darrell
title_full	Investigation on solubilisation behaviour of l-isoleucine polymorph and its associated thermodynamics properties / Vannessa Shallomy Darrell
title_fullStr	Investigation on solubilisation behaviour of l-isoleucine polymorph and its associated thermodynamics properties / Vannessa Shallomy Darrell
title_full_unstemmed	Investigation on solubilisation behaviour of l-isoleucine polymorph and its associated thermodynamics properties / Vannessa Shallomy Darrell
title_sort	investigation on solubilisation behaviour of l-isoleucine polymorph and its associated thermodynamics properties / vannessa shallomy darrell
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	College of Engineering
publishDate	2024
url	https://ir.uitm.edu.my/id/eprint/107178/1/107178.pdf
_version_	1818588212445052928

Investigation on solubilisation behaviour of l-isoleucine polymorph and its associated thermodynamics properties / Vannessa Shallomy Darrell

Similar Items