Imaging of sodium fluorescein and albumin-fluorescein isothiocyanate in biological tissue using fluorescence probe spectroscopy technique / Mohd Shahiri Abd Ghapar

Patients often prefer oral drug delivery as it is the most convenient and the safest route of administration. Question on whether or not the drug consumed might be able to reach to the intended site of action and is absorbed optimally for its therapeutic effectiveness has resulted in the development...

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Main Author:	Abd Ghapar, Mohd Shahiri
Format:	Thesis
Language:	English
Published:	2009
Subjects:	Pharmaceutical industry Pharmaceutical chemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/107209/1/107209.PDF
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id	my-uitm-ir.107209
record_format	uketd_dc
spelling	my-uitm-ir.1072092024-12-10T23:09:16Z Imaging of sodium fluorescein and albumin-fluorescein isothiocyanate in biological tissue using fluorescence probe spectroscopy technique / Mohd Shahiri Abd Ghapar 2009 Abd Ghapar, Mohd Shahiri Pharmaceutical industry Pharmaceutical chemistry Patients often prefer oral drug delivery as it is the most convenient and the safest route of administration. Question on whether or not the drug consumed might be able to reach to the intended site of action and is absorbed optimally for its therapeutic effectiveness has resulted in the development of imaging technique. Since few decades ago, there were several methods developed with the aim to image drug and other biological compounds within the body. However, these methods were relatively ineffective with regards to cost, requiring skilled personnel and knowledge, time consuming and involving complex process. This led the study to investigate the potential of fluorescence probe spectroscopy technique to image drug absorption in gastrointestinal tract. The technique was able to detect the presence of fluorescence marker solution on gastrointestinal tissue and subsequently quantify its presence. The relative fluorescence irradiation intensity varied directly with the concentration of fluorescence marker. Its spectrum was influenced by the anatomical attributes of gastrointestinal tract. 2009 Thesis https://ir.uitm.edu.my/id/eprint/107209/ https://ir.uitm.edu.my/id/eprint/107209/1/107209.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Wong, Tin Wui
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Wong, Tin Wui
topic	Pharmaceutical industry Pharmaceutical chemistry
spellingShingle	Pharmaceutical industry Pharmaceutical chemistry Abd Ghapar, Mohd Shahiri Imaging of sodium fluorescein and albumin-fluorescein isothiocyanate in biological tissue using fluorescence probe spectroscopy technique / Mohd Shahiri Abd Ghapar
description	Patients often prefer oral drug delivery as it is the most convenient and the safest route of administration. Question on whether or not the drug consumed might be able to reach to the intended site of action and is absorbed optimally for its therapeutic effectiveness has resulted in the development of imaging technique. Since few decades ago, there were several methods developed with the aim to image drug and other biological compounds within the body. However, these methods were relatively ineffective with regards to cost, requiring skilled personnel and knowledge, time consuming and involving complex process. This led the study to investigate the potential of fluorescence probe spectroscopy technique to image drug absorption in gastrointestinal tract. The technique was able to detect the presence of fluorescence marker solution on gastrointestinal tissue and subsequently quantify its presence. The relative fluorescence irradiation intensity varied directly with the concentration of fluorescence marker. Its spectrum was influenced by the anatomical attributes of gastrointestinal tract.
format	Thesis
qualification_level	Bachelor degree
author	Abd Ghapar, Mohd Shahiri
author_facet	Abd Ghapar, Mohd Shahiri
author_sort	Abd Ghapar, Mohd Shahiri
title	Imaging of sodium fluorescein and albumin-fluorescein isothiocyanate in biological tissue using fluorescence probe spectroscopy technique / Mohd Shahiri Abd Ghapar
title_short	Imaging of sodium fluorescein and albumin-fluorescein isothiocyanate in biological tissue using fluorescence probe spectroscopy technique / Mohd Shahiri Abd Ghapar
title_full	Imaging of sodium fluorescein and albumin-fluorescein isothiocyanate in biological tissue using fluorescence probe spectroscopy technique / Mohd Shahiri Abd Ghapar
title_fullStr	Imaging of sodium fluorescein and albumin-fluorescein isothiocyanate in biological tissue using fluorescence probe spectroscopy technique / Mohd Shahiri Abd Ghapar
title_full_unstemmed	Imaging of sodium fluorescein and albumin-fluorescein isothiocyanate in biological tissue using fluorescence probe spectroscopy technique / Mohd Shahiri Abd Ghapar
title_sort	imaging of sodium fluorescein and albumin-fluorescein isothiocyanate in biological tissue using fluorescence probe spectroscopy technique / mohd shahiri abd ghapar
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2009
url	https://ir.uitm.edu.my/id/eprint/107209/1/107209.PDF
_version_	1818588214760308736

Imaging of sodium fluorescein and albumin-fluorescein isothiocyanate in biological tissue using fluorescence probe spectroscopy technique / Mohd Shahiri Abd Ghapar

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