The generation of CYP2C9 knocked-down human hepatocyte library: a utilization of crispr/cas9 system / Ruhil Nadirah Che Omar

There is an issue of inconsistencies of working with hepatocytes obtained from different human liver donors in drug metabolism studies. CRISPR type II (Cas9) is the most recent development in biotechnology that could potentially resolve this limitation by precise and efficient alteration of genetic...

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Main Author:	Che Omar, Ruhil Nadirah
Format:	Thesis
Language:	English
Published:	2024
Subjects:	DNA Deoxyribonucleic acids Genetics
Online Access:	https://ir.uitm.edu.my/id/eprint/107234/1/107234.pdf
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id	my-uitm-ir.107234
record_format	uketd_dc
spelling	my-uitm-ir.1072342024-12-04T08:29:45Z The generation of CYP2C9 knocked-down human hepatocyte library: a utilization of crispr/cas9 system / Ruhil Nadirah Che Omar 2024 Che Omar, Ruhil Nadirah DNA. Deoxyribonucleic acids Genetics There is an issue of inconsistencies of working with hepatocytes obtained from different human liver donors in drug metabolism studies. CRISPR type II (Cas9) is the most recent development in biotechnology that could potentially resolve this limitation by precise and efficient alteration of genetic sequences. It works in almost any kind of living cells and became possible after the recent discovery of genome editing technologies. Clustered regularly interspaced short palindromic repeats (CRISPR) – associated nucleus (Cas), allows for small changes to a known, targeted location on the DNA sequence efficiently at a faster rate, and ease of use. 2024 Thesis https://ir.uitm.edu.my/id/eprint/107234/ https://ir.uitm.edu.my/id/eprint/107234/1/107234.pdf text en public masters Universiti Teknologi MARA (UiTM) Faculty of Pharmacy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	DNA Deoxyribonucleic acids Genetics
spellingShingle	DNA Deoxyribonucleic acids Genetics Che Omar, Ruhil Nadirah The generation of CYP2C9 knocked-down human hepatocyte library: a utilization of crispr/cas9 system / Ruhil Nadirah Che Omar
description	There is an issue of inconsistencies of working with hepatocytes obtained from different human liver donors in drug metabolism studies. CRISPR type II (Cas9) is the most recent development in biotechnology that could potentially resolve this limitation by precise and efficient alteration of genetic sequences. It works in almost any kind of living cells and became possible after the recent discovery of genome editing technologies. Clustered regularly interspaced short palindromic repeats (CRISPR) – associated nucleus (Cas), allows for small changes to a known, targeted location on the DNA sequence efficiently at a faster rate, and ease of use.
format	Thesis
qualification_level	Master's degree
author	Che Omar, Ruhil Nadirah
author_facet	Che Omar, Ruhil Nadirah
author_sort	Che Omar, Ruhil Nadirah
title	The generation of CYP2C9 knocked-down human hepatocyte library: a utilization of crispr/cas9 system / Ruhil Nadirah Che Omar
title_short	The generation of CYP2C9 knocked-down human hepatocyte library: a utilization of crispr/cas9 system / Ruhil Nadirah Che Omar
title_full	The generation of CYP2C9 knocked-down human hepatocyte library: a utilization of crispr/cas9 system / Ruhil Nadirah Che Omar
title_fullStr	The generation of CYP2C9 knocked-down human hepatocyte library: a utilization of crispr/cas9 system / Ruhil Nadirah Che Omar
title_full_unstemmed	The generation of CYP2C9 knocked-down human hepatocyte library: a utilization of crispr/cas9 system / Ruhil Nadirah Che Omar
title_sort	generation of cyp2c9 knocked-down human hepatocyte library: a utilization of crispr/cas9 system / ruhil nadirah che omar
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Pharmacy
publishDate	2024
url	https://ir.uitm.edu.my/id/eprint/107234/1/107234.pdf
_version_	1818588217096536064

The generation of CYP2C9 knocked-down human hepatocyte library: a utilization of crispr/cas9 system / Ruhil Nadirah Che Omar

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