Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar

Five Schiff base ligands were successful synthesized from 1,8-diaminonaphthalene with 2-hydroacetophenone, 5-bromo-2-hydroxyacetophenone, salicyldehyde, 2-4,dihydroxybenayldehyde and 3-hydroxy-4-methoxybenzaldehyde in the ratio 1:2. Twenty complexes of Cu(II), Co(II), Ni(II) and Zn(II) with the five...

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Main Author:	Abu Bakar, Ahmad Fauzi
Format:	Thesis
Language:	English
Published:	2013
Subjects:	Bioactive compounds
Online Access:	https://ir.uitm.edu.my/id/eprint/15528/1/TM_AHMAD%20FAUZI%20ABU%20BAKAR%20AS%2013_5.pdf
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id	my-uitm-ir.15528
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spelling	my-uitm-ir.155282022-04-18T02:11:29Z Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar 2013-08 Abu Bakar, Ahmad Fauzi Bioactive compounds Five Schiff base ligands were successful synthesized from 1,8-diaminonaphthalene with 2-hydroacetophenone, 5-bromo-2-hydroxyacetophenone, salicyldehyde, 2-4,dihydroxybenayldehyde and 3-hydroxy-4-methoxybenzaldehyde in the ratio 1:2. Twenty complexes of Cu(II), Co(II), Ni(II) and Zn(II) with the five ligands were obtained with 1:1 ratio of ligand:metal. The chemical structures were investigated and elucidated using elemental analysis (C,H,N), infrared spectroscopy, 1 H and 13C nuclear magnetic resonance spectroscopy, ultraviolet-visible spectroscopy, melting point measurement and magnetic susceptibility measurement. The paramagnetic Cu(II) and Co(II) complexes were observed to display v(C=N) band in the range 1601 to 1638 cm'1, while those of the diamagnetic Ni(II) and Zn(II) complexes displayed v(C=N) band in the region 1587 to 1638 cm'1. From the effective magnetic moment (\|^eff) values, it was indicate that the nickel(II) complexes adopted square planar geometry while all the cobalt(II) complexes were tetrahedral. The representative compounds of CoLl and LI showed UV-Vis absorption bands at 260 to 332 nm assignable to n—>n* transition of the aromatic systems. The band at 298 nm for ligand was likely due to n—>n* and tt— electron transitions of the conjugated C=C chromophore of the naphthalene and phenyl moieties. Absorption for cobalt(II) complex showed a bathocromical shift to the free ligand, caused by the coordination of metal to the ligand, in agreement with the IR spectral results. The neurotoxicity screening on treated human neuroblastoma SH-SY5Y cell lines revealed that the compound were not toxic to the cell line. 2013-08 Thesis https://ir.uitm.edu.my/id/eprint/15528/ https://ir.uitm.edu.my/id/eprint/15528/1/TM_AHMAD%20FAUZI%20ABU%20BAKAR%20AS%2013_5.pdf text en public mphil masters Universiti Teknologi MARA Faculty of Applied Science Bahron, Hadariah (Professor Dr.) Kassim, Karimah (Dr.)
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Bahron, Hadariah (Professor Dr.) Kassim, Karimah (Dr.)
topic	Bioactive compounds
spellingShingle	Bioactive compounds Abu Bakar, Ahmad Fauzi Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar
description	Five Schiff base ligands were successful synthesized from 1,8-diaminonaphthalene with 2-hydroacetophenone, 5-bromo-2-hydroxyacetophenone, salicyldehyde, 2-4,dihydroxybenayldehyde and 3-hydroxy-4-methoxybenzaldehyde in the ratio 1:2. Twenty complexes of Cu(II), Co(II), Ni(II) and Zn(II) with the five ligands were obtained with 1:1 ratio of ligand:metal. The chemical structures were investigated and elucidated using elemental analysis (C,H,N), infrared spectroscopy, 1 H and 13C nuclear magnetic resonance spectroscopy, ultraviolet-visible spectroscopy, melting point measurement and magnetic susceptibility measurement. The paramagnetic Cu(II) and Co(II) complexes were observed to display v(C=N) band in the range 1601 to 1638 cm'1, while those of the diamagnetic Ni(II) and Zn(II) complexes displayed v(C=N) band in the region 1587 to 1638 cm'1. From the effective magnetic moment (\|^eff) values, it was indicate that the nickel(II) complexes adopted square planar geometry while all the cobalt(II) complexes were tetrahedral. The representative compounds of CoLl and LI showed UV-Vis absorption bands at 260 to 332 nm assignable to n—>n* transition of the aromatic systems. The band at 298 nm for ligand was likely due to n—>n* and tt— electron transitions of the conjugated C=C chromophore of the naphthalene and phenyl moieties. Absorption for cobalt(II) complex showed a bathocromical shift to the free ligand, caused by the coordination of metal to the ligand, in agreement with the IR spectral results. The neurotoxicity screening on treated human neuroblastoma SH-SY5Y cell lines revealed that the compound were not toxic to the cell line.
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Abu Bakar, Ahmad Fauzi
author_facet	Abu Bakar, Ahmad Fauzi
author_sort	Abu Bakar, Ahmad Fauzi
title	Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar
title_short	Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar
title_full	Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar
title_fullStr	Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar
title_full_unstemmed	Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar
title_sort	synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-diaminonaphthalene and their cu(ii), co(ii), ni(ii) and zn(ii) complexes / ahmad fauzi abu bakar
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Applied Science
publishDate	2013
url	https://ir.uitm.edu.my/id/eprint/15528/1/TM_AHMAD%20FAUZI%20ABU%20BAKAR%20AS%2013_5.pdf
_version_	1783733415592329216

Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar

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