Design of pectin-chitosan nanoparticles as oral insulin carrier / Syed Mohamad Al-Azi Syed Othman

Polymeric nanoparticles are characterized by high risks of premature drug dissolution and low drug encapsulation efficiency. The latter is aggravated by slow nanoparticle formation from large molecular weight polymers due to their slow diffusion kinetics in the reaction medium. This study investigat...

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Main Author:	Syed Othman, Syed Mohamad Al-Azi
Format:	Thesis
Language:	English
Published:	2015
Online Access:	https://ir.uitm.edu.my/id/eprint/15978/1/TM_SYED%20MOHAMAD%20AL-AZI%20SYED%20OTHMAN%20PH%2015_5.pdf
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id	my-uitm-ir.15978
record_format	uketd_dc
spelling	my-uitm-ir.159782022-03-04T01:40:27Z Design of pectin-chitosan nanoparticles as oral insulin carrier / Syed Mohamad Al-Azi Syed Othman 2015 Syed Othman, Syed Mohamad Al-Azi Polymeric nanoparticles are characterized by high risks of premature drug dissolution and low drug encapsulation efficiency. The latter is aggravated by slow nanoparticle formation from large molecular weight polymers due to their slow diffusion kinetics in the reaction medium. This study investigated large molecular weight pectin-chitosan coacervate in insulin encapsulation and sustained release. The nanoparticles were prepared through coacervation of pectin-insulin and chitosan with tripolyphosphate anions in pectin-insulin mixture, or calcium cations in chitosan solution. The formed particles were nanospray-dried when required. The size, zeta potential, morphology, drug content, drug association efficiency, drug release, polymer-polymer and drug-polymer interaction in particulate matrix were examined. Both non-crosslinked and crosslinked pectin-chitosan nanoparticles failed to encapsulate insulin substantially, unless nanoparticles were formed with rapid particle aggregation into micromatrices during coacervation. The aggregation level of nanoparticles can be reduced via spray drying and disaggregation of the particle clusters. These nanoparticles demonstrated fast drug release and chitosan dissolution. The chitosan dissolves readily in intestinal medium and can be utilised to increase mucosal permeability of the promptly released insulin in future endeavour. 2015 Thesis https://ir.uitm.edu.my/id/eprint/15978/ https://ir.uitm.edu.my/id/eprint/15978/1/TM_SYED%20MOHAMAD%20AL-AZI%20SYED%20OTHMAN%20PH%2015_5.pdf text en public mphil masters Universiti Teknologi MARA Faculty of Pharmacy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
description	Polymeric nanoparticles are characterized by high risks of premature drug dissolution and low drug encapsulation efficiency. The latter is aggravated by slow nanoparticle formation from large molecular weight polymers due to their slow diffusion kinetics in the reaction medium. This study investigated large molecular weight pectin-chitosan coacervate in insulin encapsulation and sustained release. The nanoparticles were prepared through coacervation of pectin-insulin and chitosan with tripolyphosphate anions in pectin-insulin mixture, or calcium cations in chitosan solution. The formed particles were nanospray-dried when required. The size, zeta potential, morphology, drug content, drug association efficiency, drug release, polymer-polymer and drug-polymer interaction in particulate matrix were examined. Both non-crosslinked and crosslinked pectin-chitosan nanoparticles failed to encapsulate insulin substantially, unless nanoparticles were formed with rapid particle aggregation into micromatrices during coacervation. The aggregation level of nanoparticles can be reduced via spray drying and disaggregation of the particle clusters. These nanoparticles demonstrated fast drug release and chitosan dissolution. The chitosan dissolves readily in intestinal medium and can be utilised to increase mucosal permeability of the promptly released insulin in future endeavour.
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Syed Othman, Syed Mohamad Al-Azi
spellingShingle	Syed Othman, Syed Mohamad Al-Azi Design of pectin-chitosan nanoparticles as oral insulin carrier / Syed Mohamad Al-Azi Syed Othman
author_facet	Syed Othman, Syed Mohamad Al-Azi
author_sort	Syed Othman, Syed Mohamad Al-Azi
title	Design of pectin-chitosan nanoparticles as oral insulin carrier / Syed Mohamad Al-Azi Syed Othman
title_short	Design of pectin-chitosan nanoparticles as oral insulin carrier / Syed Mohamad Al-Azi Syed Othman
title_full	Design of pectin-chitosan nanoparticles as oral insulin carrier / Syed Mohamad Al-Azi Syed Othman
title_fullStr	Design of pectin-chitosan nanoparticles as oral insulin carrier / Syed Mohamad Al-Azi Syed Othman
title_full_unstemmed	Design of pectin-chitosan nanoparticles as oral insulin carrier / Syed Mohamad Al-Azi Syed Othman
title_sort	design of pectin-chitosan nanoparticles as oral insulin carrier / syed mohamad al-azi syed othman
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Pharmacy
publishDate	2015
url	https://ir.uitm.edu.my/id/eprint/15978/1/TM_SYED%20MOHAMAD%20AL-AZI%20SYED%20OTHMAN%20PH%2015_5.pdf
_version_	1783733472180830208

Design of pectin-chitosan nanoparticles as oral insulin carrier / Syed Mohamad Al-Azi Syed Othman

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