Herb-in vitro cyp interaction of Cytochrome P1A2 on Malaysian traditional herbs / Nur Amirah Mohd Noor Azami

Many people believe that traditional medicine can be use as alternative to treat many diseases and some of them take both medicines at same time. They do not notice that there have risks of interactions between herbs and drug leading to toxicity or loss of therapeutic efficacy. The purpose of thi...

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Main Author:	Mohd Noor Azami, Nur Amirah
Format:	Thesis
Language:	English
Published:	2010
Subjects:	Medical botany (General)
Online Access:	https://ir.uitm.edu.my/id/eprint/2247/1/TD_NUR%20AMIRAH%20MOHD%20NOOR%20AZAMI%20PH%2010_5.pdf
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id	my-uitm-ir.2247
record_format	uketd_dc
spelling	my-uitm-ir.22472017-08-03T04:18:06Z Herb-in vitro cyp interaction of Cytochrome P1A2 on Malaysian traditional herbs / Nur Amirah Mohd Noor Azami 2010 Mohd Noor Azami, Nur Amirah Medical botany (General) RM Therapeutics. Pharmacology Many people believe that traditional medicine can be use as alternative to treat many diseases and some of them take both medicines at same time. They do not notice that there have risks of interactions between herbs and drug leading to toxicity or loss of therapeutic efficacy. The purpose of this study is to evaluate the interactions of Malaysian traditional herbs with CYP1A2 enzymes. CYP1A2 is one of the major member of CYP and it constitute about 12-20% of the total CYP content and it mostly a hepatic enzymes. Vivid®CYP450 Screening Kit had been use to study the inhibition activity of Malaysian traditional herbs. α-naphthoflavone is use as positive control that showed 100% inhibition and solvents control which is DMSO showed 0% inhibition or no inhibition. Result showed 27 herb which are Biji kedaung, Bunga mukmin, Cabai pintal, Getah katira, Halba, Kadukai besar, Kadukai kecil, Kacip Fatimah, Kayu angin, Kayu lilit, Ketumbar, Kulit kayu manis, Lada pahit, Lebai samad, Lengkuas, Manjalawi, Mas cotek, Pakawali, Pegaga, Pinang, Pulau waras sari, Selasih, Sembaranthu, Senduduk, Serai wangi, Tenggek burung and Tering pipit show inhibitions at concentration 0.1mg/ml. From 56 Malaysian traditional herbs species, there are 27 herbs shown inhibition on concentration 1 mg/ml which is Kulit kayu manis, Pulau waras sari, Sembaranthu and Senduduk. Other herbs do not show any significant inhibition. Keywords: CYP1A2, Malaysian traditional herb, inhibition Faculty of Pharmacy 2010 Thesis https://ir.uitm.edu.my/id/eprint/2247/ https://ir.uitm.edu.my/id/eprint/2247/1/TD_NUR%20AMIRAH%20MOHD%20NOOR%20AZAMI%20PH%2010_5.pdf text en public other degree Universiti Teknologi MARA Faculty of Pharmacy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Medical botany (General) Medical botany (General)
spellingShingle	Medical botany (General) Medical botany (General) Mohd Noor Azami, Nur Amirah Herb-in vitro cyp interaction of Cytochrome P1A2 on Malaysian traditional herbs / Nur Amirah Mohd Noor Azami
description	Many people believe that traditional medicine can be use as alternative to treat many diseases and some of them take both medicines at same time. They do not notice that there have risks of interactions between herbs and drug leading to toxicity or loss of therapeutic efficacy. The purpose of this study is to evaluate the interactions of Malaysian traditional herbs with CYP1A2 enzymes. CYP1A2 is one of the major member of CYP and it constitute about 12-20% of the total CYP content and it mostly a hepatic enzymes. Vivid®CYP450 Screening Kit had been use to study the inhibition activity of Malaysian traditional herbs. α-naphthoflavone is use as positive control that showed 100% inhibition and solvents control which is DMSO showed 0% inhibition or no inhibition. Result showed 27 herb which are Biji kedaung, Bunga mukmin, Cabai pintal, Getah katira, Halba, Kadukai besar, Kadukai kecil, Kacip Fatimah, Kayu angin, Kayu lilit, Ketumbar, Kulit kayu manis, Lada pahit, Lebai samad, Lengkuas, Manjalawi, Mas cotek, Pakawali, Pegaga, Pinang, Pulau waras sari, Selasih, Sembaranthu, Senduduk, Serai wangi, Tenggek burung and Tering pipit show inhibitions at concentration 0.1mg/ml. From 56 Malaysian traditional herbs species, there are 27 herbs shown inhibition on concentration 1 mg/ml which is Kulit kayu manis, Pulau waras sari, Sembaranthu and Senduduk. Other herbs do not show any significant inhibition. Keywords: CYP1A2, Malaysian traditional herb, inhibition
format	Thesis
qualification_name	other
qualification_level	Bachelor degree
author	Mohd Noor Azami, Nur Amirah
author_facet	Mohd Noor Azami, Nur Amirah
author_sort	Mohd Noor Azami, Nur Amirah
title	Herb-in vitro cyp interaction of Cytochrome P1A2 on Malaysian traditional herbs / Nur Amirah Mohd Noor Azami
title_short	Herb-in vitro cyp interaction of Cytochrome P1A2 on Malaysian traditional herbs / Nur Amirah Mohd Noor Azami
title_full	Herb-in vitro cyp interaction of Cytochrome P1A2 on Malaysian traditional herbs / Nur Amirah Mohd Noor Azami
title_fullStr	Herb-in vitro cyp interaction of Cytochrome P1A2 on Malaysian traditional herbs / Nur Amirah Mohd Noor Azami
title_full_unstemmed	Herb-in vitro cyp interaction of Cytochrome P1A2 on Malaysian traditional herbs / Nur Amirah Mohd Noor Azami
title_sort	herb-in vitro cyp interaction of cytochrome p1a2 on malaysian traditional herbs / nur amirah mohd noor azami
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Pharmacy
publishDate	2010
url	https://ir.uitm.edu.my/id/eprint/2247/1/TD_NUR%20AMIRAH%20MOHD%20NOOR%20AZAMI%20PH%2010_5.pdf
_version_	1783733069432225792

Herb-in vitro cyp interaction of Cytochrome P1A2 on Malaysian traditional herbs / Nur Amirah Mohd Noor Azami

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