Utilization of non-steroidal anti-inflammatory drugs in orthopaedic ward at Ampang Hospital / Nur Aini Salamat

Non-steroidal Anti-Inflammatory Drugs (NSAIDs) are among the most frequently prescribed medications worldwide. NSAIDs are among the group of drugs which contribute to most-reported cases of adverse drug reactions and their safety profiles always become a concern. Despite its therapeutic effects, man...

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Main Author:	Salamat, Nur Aini
Format:	Thesis
Language:	English
Published:	2015
Subjects:	Drugs prescribing Materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/26176/1/TM_NUR%20AINI%20SALAMAT%20PH%2015_5.pdf
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id	my-uitm-ir.26176
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spelling	my-uitm-ir.261762019-11-18T03:26:16Z Utilization of non-steroidal anti-inflammatory drugs in orthopaedic ward at Ampang Hospital / Nur Aini Salamat 2015 Salamat, Nur Aini Drugs prescribing Materia medica Non-steroidal Anti-Inflammatory Drugs (NSAIDs) are among the most frequently prescribed medications worldwide. NSAIDs are among the group of drugs which contribute to most-reported cases of adverse drug reactions and their safety profiles always become a concern. Despite its therapeutic effects, many studies have shown that chronic NSAIDs use heightens the risk of gastrointestinal complications, acute renal failure, and cardiovascular event. This is a retrospective drug utilization study of NSAIDs available at Ampang Hospital. Patient’s data were extracted from electronic system namely eHIS. The objective of the study is to describe the utilization pattern of NSAIDs in orthopaedic ward at Ampang Hospital. The specific objectives for this study are to assess the pattern of NSAIDs prescribed, to estimate Define Daily Dose (DDD) for each NSAIDs prescribed, to determine relation in pattern of NSAIDs usage with patient’s characteristics and to identify potential NSAIDs prescription related problem. A total of 210 patient records were retrieved from eHIS system in Ampang Hospital with the median age of 31 years old. Based on the DDD’s calculated, the most prescribed NSAIDs were diclofenac tablet (80.46), diclofenac injection (19.25), meloxicam (1.25) and ibuprofen (0.35). Majority of patients received NSAIDs for 4 to7 days. Analgesics were being prescribed to the patients in the ward regardless types of pain and types of disorder (p=0.280, p=0.299) respectively. However, types of injury with p-value of 0.007 showed that it has statistically associated with types of analgesic prescribed during study period. Among the NSAIDs user, there were 8.4% had chronic conditions such as hypertension, diabetes mellitus and cardiovascular disease. The prevalence of concurrent antihypertensive usage among all NSAIDs user were 1.8%. All potential drug-drug interactions with NSAIDs were involving diuretics and ACE Inhibitors. This study also able to show NSAIDs drug utilization practice among patients especially who were at risk for NSAIDs adverse event or who have chronic conditions that should be monitored closely for adverse event. Within one year after the study period, none of the patient has been admitted due to gastrointestinal complications but there were 3.2% patients being started on gastroprotective agent. Nevertheless, the gastrointestinal complications were not dependent on age group, gender and ethnicity factor (p=0.606, p=0.269, p=0.163) respectively. These results should raise awareness to prescribers and pharmacist of such risks and work collaboratively to encourage safe prescribing and use of NSAIDs. Pharmacist also plays a key role in the overall operation of the drug utilization program to provide a more comprehensive understanding of NSAIDs utilization pattern. 2015 Thesis https://ir.uitm.edu.my/id/eprint/26176/ https://ir.uitm.edu.my/id/eprint/26176/1/TM_NUR%20AINI%20SALAMAT%20PH%2015_5.pdf text en public masters Universiti Teknologi MARA Faculty of Pharmacy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Drugs prescribing Materia medica
spellingShingle	Drugs prescribing Materia medica Salamat, Nur Aini Utilization of non-steroidal anti-inflammatory drugs in orthopaedic ward at Ampang Hospital / Nur Aini Salamat
description	Non-steroidal Anti-Inflammatory Drugs (NSAIDs) are among the most frequently prescribed medications worldwide. NSAIDs are among the group of drugs which contribute to most-reported cases of adverse drug reactions and their safety profiles always become a concern. Despite its therapeutic effects, many studies have shown that chronic NSAIDs use heightens the risk of gastrointestinal complications, acute renal failure, and cardiovascular event. This is a retrospective drug utilization study of NSAIDs available at Ampang Hospital. Patient’s data were extracted from electronic system namely eHIS. The objective of the study is to describe the utilization pattern of NSAIDs in orthopaedic ward at Ampang Hospital. The specific objectives for this study are to assess the pattern of NSAIDs prescribed, to estimate Define Daily Dose (DDD) for each NSAIDs prescribed, to determine relation in pattern of NSAIDs usage with patient’s characteristics and to identify potential NSAIDs prescription related problem. A total of 210 patient records were retrieved from eHIS system in Ampang Hospital with the median age of 31 years old. Based on the DDD’s calculated, the most prescribed NSAIDs were diclofenac tablet (80.46), diclofenac injection (19.25), meloxicam (1.25) and ibuprofen (0.35). Majority of patients received NSAIDs for 4 to7 days. Analgesics were being prescribed to the patients in the ward regardless types of pain and types of disorder (p=0.280, p=0.299) respectively. However, types of injury with p-value of 0.007 showed that it has statistically associated with types of analgesic prescribed during study period. Among the NSAIDs user, there were 8.4% had chronic conditions such as hypertension, diabetes mellitus and cardiovascular disease. The prevalence of concurrent antihypertensive usage among all NSAIDs user were 1.8%. All potential drug-drug interactions with NSAIDs were involving diuretics and ACE Inhibitors. This study also able to show NSAIDs drug utilization practice among patients especially who were at risk for NSAIDs adverse event or who have chronic conditions that should be monitored closely for adverse event. Within one year after the study period, none of the patient has been admitted due to gastrointestinal complications but there were 3.2% patients being started on gastroprotective agent. Nevertheless, the gastrointestinal complications were not dependent on age group, gender and ethnicity factor (p=0.606, p=0.269, p=0.163) respectively. These results should raise awareness to prescribers and pharmacist of such risks and work collaboratively to encourage safe prescribing and use of NSAIDs. Pharmacist also plays a key role in the overall operation of the drug utilization program to provide a more comprehensive understanding of NSAIDs utilization pattern.
format	Thesis
qualification_level	Master's degree
author	Salamat, Nur Aini
author_facet	Salamat, Nur Aini
author_sort	Salamat, Nur Aini
title	Utilization of non-steroidal anti-inflammatory drugs in orthopaedic ward at Ampang Hospital / Nur Aini Salamat
title_short	Utilization of non-steroidal anti-inflammatory drugs in orthopaedic ward at Ampang Hospital / Nur Aini Salamat
title_full	Utilization of non-steroidal anti-inflammatory drugs in orthopaedic ward at Ampang Hospital / Nur Aini Salamat
title_fullStr	Utilization of non-steroidal anti-inflammatory drugs in orthopaedic ward at Ampang Hospital / Nur Aini Salamat
title_full_unstemmed	Utilization of non-steroidal anti-inflammatory drugs in orthopaedic ward at Ampang Hospital / Nur Aini Salamat
title_sort	utilization of non-steroidal anti-inflammatory drugs in orthopaedic ward at ampang hospital / nur aini salamat
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Pharmacy
publishDate	2015
url	https://ir.uitm.edu.my/id/eprint/26176/1/TM_NUR%20AINI%20SALAMAT%20PH%2015_5.pdf
_version_	1783733885889150976

Utilization of non-steroidal anti-inflammatory drugs in orthopaedic ward at Ampang Hospital / Nur Aini Salamat

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