Adverse drug reactions of anti tuberculosis drugs among tuberculosis patients treated in Hospital Sg. Buloh / Nurniza Nisbar

AIM: To analyse and assess common types of ADRs induced by anti-TB drugs in the study population by studying the adverse drug reactions, common ADRs, common drugs accounting for ADRs, systems involvement, causality and severity. In addition to identifying the risk factors and predictors associated w...

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Main Author:	Nisbar, Nurniza
Format:	Thesis
Language:	English
Published:	2016
Subjects:	Drugs prescribing
Online Access:	https://ir.uitm.edu.my/id/eprint/26193/1/TM_NURNIZA%20NISBAR%20PH%2016_5.pdf
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id	my-uitm-ir.26193
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spelling	my-uitm-ir.261932019-10-15T07:38:16Z Adverse drug reactions of anti tuberculosis drugs among tuberculosis patients treated in Hospital Sg. Buloh / Nurniza Nisbar 2016 Nisbar, Nurniza Drugs prescribing Antibiotic therapy. Antibiotics AIM: To analyse and assess common types of ADRs induced by anti-TB drugs in the study population by studying the adverse drug reactions, common ADRs, common drugs accounting for ADRs, systems involvement, causality and severity. In addition to identifying the risk factors and predictors associated with ADRs induced by anti-TB drugs in the study population, it is also to observe the management of the ADRs in the study population. METHODS: A retrospective observational record review study performed in Hospital Sg. Buloh, Selangor. 160 clinically diagnosed TB in-patients and/or out-patients who visited the Infectious Disease Unit in Hospital Sg. Buloh who received the anti- tuberculosis regimen according to the protocol for TB treatment were included. Patient’s data were accessed retrospectively through electronic medical records. Descriptive data were analysed using frequency and percentage. Simple logistic regression was used for univariate analyses. Factors with significant p value were analysed using multiple logistic regression. RESULTS: A third of patients experienced ADR with half of the sample experiencing ADRs in short period of time (within the first 14 days). Half of our sample subjects had a “possible” causal reactions whereby two thirds of those suffering from an ADR had a severe reaction. Seven factors were identified as possible predictors which include age of between 41 to 50 years (p =. 041), 51 to 60 years (p =.101), female gender (p =.234), Malay ethnicity (p =.242), drug allergy (p =.225), pulmonary-TB (p =.160), intensive phase regime with HREZ (p =.027) and maintenance phase regime with HR (p =.020). Final analysis with multiple logistic regression however shown factors included were not significantly associated with ADRs. CONCLUSION: The data obtained from this study has helped to uncover the statistical characteristics and estimate the burden in dealing with ADRs with anti-TB in Hospital Sg. Buloh. The possible risk factors that contributed to adverse drug reactions with anti-TB drugs in our sample were identified and therefore would facilitate physicians to screen and make prompt diagnosis of these ADRs, provide early management and counselling which will improve the outcomes of TB treatment. 2016 Thesis https://ir.uitm.edu.my/id/eprint/26193/ https://ir.uitm.edu.my/id/eprint/26193/1/TM_NURNIZA%20NISBAR%20PH%2016_5.pdf text en public masters Universiti Teknologi MARA Faculty of Pharmacy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Drugs prescribing Drugs prescribing
spellingShingle	Drugs prescribing Drugs prescribing Nisbar, Nurniza Adverse drug reactions of anti tuberculosis drugs among tuberculosis patients treated in Hospital Sg. Buloh / Nurniza Nisbar
description	AIM: To analyse and assess common types of ADRs induced by anti-TB drugs in the study population by studying the adverse drug reactions, common ADRs, common drugs accounting for ADRs, systems involvement, causality and severity. In addition to identifying the risk factors and predictors associated with ADRs induced by anti-TB drugs in the study population, it is also to observe the management of the ADRs in the study population. METHODS: A retrospective observational record review study performed in Hospital Sg. Buloh, Selangor. 160 clinically diagnosed TB in-patients and/or out-patients who visited the Infectious Disease Unit in Hospital Sg. Buloh who received the anti- tuberculosis regimen according to the protocol for TB treatment were included. Patient’s data were accessed retrospectively through electronic medical records. Descriptive data were analysed using frequency and percentage. Simple logistic regression was used for univariate analyses. Factors with significant p value were analysed using multiple logistic regression. RESULTS: A third of patients experienced ADR with half of the sample experiencing ADRs in short period of time (within the first 14 days). Half of our sample subjects had a “possible” causal reactions whereby two thirds of those suffering from an ADR had a severe reaction. Seven factors were identified as possible predictors which include age of between 41 to 50 years (p =. 041), 51 to 60 years (p =.101), female gender (p =.234), Malay ethnicity (p =.242), drug allergy (p =.225), pulmonary-TB (p =.160), intensive phase regime with HREZ (p =.027) and maintenance phase regime with HR (p =.020). Final analysis with multiple logistic regression however shown factors included were not significantly associated with ADRs. CONCLUSION: The data obtained from this study has helped to uncover the statistical characteristics and estimate the burden in dealing with ADRs with anti-TB in Hospital Sg. Buloh. The possible risk factors that contributed to adverse drug reactions with anti-TB drugs in our sample were identified and therefore would facilitate physicians to screen and make prompt diagnosis of these ADRs, provide early management and counselling which will improve the outcomes of TB treatment.
format	Thesis
qualification_level	Master's degree
author	Nisbar, Nurniza
author_facet	Nisbar, Nurniza
author_sort	Nisbar, Nurniza
title	Adverse drug reactions of anti tuberculosis drugs among tuberculosis patients treated in Hospital Sg. Buloh / Nurniza Nisbar
title_short	Adverse drug reactions of anti tuberculosis drugs among tuberculosis patients treated in Hospital Sg. Buloh / Nurniza Nisbar
title_full	Adverse drug reactions of anti tuberculosis drugs among tuberculosis patients treated in Hospital Sg. Buloh / Nurniza Nisbar
title_fullStr	Adverse drug reactions of anti tuberculosis drugs among tuberculosis patients treated in Hospital Sg. Buloh / Nurniza Nisbar
title_full_unstemmed	Adverse drug reactions of anti tuberculosis drugs among tuberculosis patients treated in Hospital Sg. Buloh / Nurniza Nisbar
title_sort	adverse drug reactions of anti tuberculosis drugs among tuberculosis patients treated in hospital sg. buloh / nurniza nisbar
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Pharmacy
publishDate	2016
url	https://ir.uitm.edu.my/id/eprint/26193/1/TM_NURNIZA%20NISBAR%20PH%2016_5.pdf
_version_	1783733886387224576

Adverse drug reactions of anti tuberculosis drugs among tuberculosis patients treated in Hospital Sg. Buloh / Nurniza Nisbar

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