Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin

Colistin is an old antibiotic which use has been abandoned due to its nephrotoxicity. The rise of multidrug- resistance bacterial infections over the decade has led to the resurgence of colistin use. Since then, researches have taken interest into colistin including the incidence and predictors of c...

Full description

Saved in:

Bibliographic Details
Main Author:	Kamaludin, Ros Sakinah
Format:	Thesis
Language:	English
Published:	2016
Subjects:	Examination Diagnosis Including radiography
Online Access:	https://ir.uitm.edu.my/id/eprint/26257/1/TM_ROS%20SAKINAH%20KAMALUDIN%20PH%2016_5.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-uitm-ir.26257
record_format	uketd_dc
spelling	my-uitm-ir.262572019-10-23T08:40:27Z Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin 2016 Kamaludin, Ros Sakinah Examination. Diagnosis. Including radiography Colistin is an old antibiotic which use has been abandoned due to its nephrotoxicity. The rise of multidrug- resistance bacterial infections over the decade has led to the resurgence of colistin use. Since then, researches have taken interest into colistin including the incidence and predictors of colistin- associated acute kidney injury (AKI). Studies in other regions reported a wide range of incidence and multiple predictors of colistin- associated AKI. Since to date there is no such data from local healthcare setting, this retrospective cohort study aimed to determine the incidence and predictors of colistin- associated AKI in a Malaysian tertiary healthcare. 77 adult patients who received intravenous (IV) colistin in Hospital Raja Permaisuri Bainun in 2014 until September 2015 were included in the analysis. The incidence of colistin- associated AKI was 31.2% based on the Risk, Injury, Failure; Loss and End- stage Renal Disease (RIFLE) criteria employed. The predictors of colistin- associated AKI found were the length of hospital stay prior to colistin initiation (OR 1.044, 95% CI 1.004- 1.085; p= 0.03) and mechanical ventilation (OR 3.706, 95% CI 1.062- 12.940; p= 0.04). Study population profile and colistin regimen characteristics were comparable to those demonstrated by previous studies. Drug- event causality assessment using Naranjo Adverse Drug Reaction Scale revealed all of the AKI cases fell into ‘Possible’ category. The reported incidence validates the concern of colistin- associated AKI. Even though the predictors of such event varied, efforts to minimize colistin- associated AKI by controlling the risk factors are consistently warranted. 2016 Thesis https://ir.uitm.edu.my/id/eprint/26257/ https://ir.uitm.edu.my/id/eprint/26257/1/TM_ROS%20SAKINAH%20KAMALUDIN%20PH%2016_5.pdf text en public masters Universiti Teknologi MARA Faculty of Pharmacy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Examination Diagnosis Including radiography
spellingShingle	Examination Diagnosis Including radiography Kamaludin, Ros Sakinah Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin
description	Colistin is an old antibiotic which use has been abandoned due to its nephrotoxicity. The rise of multidrug- resistance bacterial infections over the decade has led to the resurgence of colistin use. Since then, researches have taken interest into colistin including the incidence and predictors of colistin- associated acute kidney injury (AKI). Studies in other regions reported a wide range of incidence and multiple predictors of colistin- associated AKI. Since to date there is no such data from local healthcare setting, this retrospective cohort study aimed to determine the incidence and predictors of colistin- associated AKI in a Malaysian tertiary healthcare. 77 adult patients who received intravenous (IV) colistin in Hospital Raja Permaisuri Bainun in 2014 until September 2015 were included in the analysis. The incidence of colistin- associated AKI was 31.2% based on the Risk, Injury, Failure; Loss and End- stage Renal Disease (RIFLE) criteria employed. The predictors of colistin- associated AKI found were the length of hospital stay prior to colistin initiation (OR 1.044, 95% CI 1.004- 1.085; p= 0.03) and mechanical ventilation (OR 3.706, 95% CI 1.062- 12.940; p= 0.04). Study population profile and colistin regimen characteristics were comparable to those demonstrated by previous studies. Drug- event causality assessment using Naranjo Adverse Drug Reaction Scale revealed all of the AKI cases fell into ‘Possible’ category. The reported incidence validates the concern of colistin- associated AKI. Even though the predictors of such event varied, efforts to minimize colistin- associated AKI by controlling the risk factors are consistently warranted.
format	Thesis
qualification_level	Master's degree
author	Kamaludin, Ros Sakinah
author_facet	Kamaludin, Ros Sakinah
author_sort	Kamaludin, Ros Sakinah
title	Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin
title_short	Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin
title_full	Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin
title_fullStr	Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin
title_full_unstemmed	Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin
title_sort	incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / ros sakinah kamaludin
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Pharmacy
publishDate	2016
url	https://ir.uitm.edu.my/id/eprint/26257/1/TM_ROS%20SAKINAH%20KAMALUDIN%20PH%2016_5.pdf
_version_	1783733888402587648

Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin

Similar Items