The efficacy of Super-oxidised Hydrogel versus Aqueous Cream in treatment of mild to moderate Atopic Dermatitis / Nabia Idaam Mustapa Albakari

Background and Aims. Super-oxidised hydrogel incorporated into a formulated moisturiser (EZyma® Hydrogel), is a non-steroidal anti-inflammatory option for treatment of Atopic Dermatitis. This study aimed to evaluate the efficacy of superoxidised hydrogel as an adjunct treatment in improving symptoms...

Full description

Saved in:

Bibliographic Details
Main Author:	Mustapa Albakari, Nabia Idaam
Format:	Thesis
Language:	English
Published:	2019
Subjects:	Diseases associated with hypersensitivity Allergic diseases of the skin TP Chemical technology
Online Access:	https://ir.uitm.edu.my/id/eprint/29731/1/29731.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-uitm-ir.29731
record_format	uketd_dc
spelling	my-uitm-ir.297312022-07-16T15:45:58Z The efficacy of Super-oxidised Hydrogel versus Aqueous Cream in treatment of mild to moderate Atopic Dermatitis / Nabia Idaam Mustapa Albakari 2019-04 Mustapa Albakari, Nabia Idaam Diseases associated with hypersensitivity. Allergic diseases of the skin TP Chemical technology Background and Aims. Super-oxidised hydrogel incorporated into a formulated moisturiser (EZyma® Hydrogel), is a non-steroidal anti-inflammatory option for treatment of Atopic Dermatitis. This study aimed to evaluate the efficacy of superoxidised hydrogel as an adjunct treatment in improving symptoms and signs of mild to moderate AD, hence improving patient’s quality of life compared to moisturising treatment with aqueous cream. Methodology. This was a single centre, prospective, parallel, investigator-blinded clinical study in adult with mild to moderate Atopic dermatitis. Subjects were given super-oxidised hydrogel or aqueous cream (1:1) three times a day to areas affected by atopic dermatitis for 2 weeks. A change of assessment score (EASI and subjective SCORAD) and quality of life score (DLQI) from baseline was determined at week 1 and week 2. Results. A total of 60 patients with mean ageSD of 28.607.770 were enrolled. Study showed that treated area of AD improved in both treatment arms. Both treatments showed reduction of mean in all efficacy scores and DLQI scores from baseline to week 2. The effect was not statistically significant between the two arms. This suggest that super-oxidised hydrogel was comparable to aqueous cream as a moisturiser. There was no mean significant difference in terms of the hydrocortisone cream usage. Two subjects in aqueous cream group reported mild self-limiting side effects. Conclusion. Super-oxidised hydrogel is beneficial as treatment for atopic dermatitis in improving local signs assessed by EASI score, and its symptom mainly the pruritis. It is safe and should be considered as an alternative moisturiser. A larger study population is required to look at its efficacy after longer period of usage. 2019-04 Thesis https://ir.uitm.edu.my/id/eprint/29731/ https://ir.uitm.edu.my/id/eprint/29731/1/29731.pdf text en public masters Universiti Teknologi MARA (Kampus Sg. Buloh) Faculty of Medicine Taib, Tarita Isa, Mohamad Rodi
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Taib, Tarita Isa, Mohamad Rodi
topic	Diseases associated with hypersensitivity Allergic diseases of the skin TP Chemical technology
spellingShingle	Diseases associated with hypersensitivity Allergic diseases of the skin TP Chemical technology Mustapa Albakari, Nabia Idaam The efficacy of Super-oxidised Hydrogel versus Aqueous Cream in treatment of mild to moderate Atopic Dermatitis / Nabia Idaam Mustapa Albakari
description	Background and Aims. Super-oxidised hydrogel incorporated into a formulated moisturiser (EZyma® Hydrogel), is a non-steroidal anti-inflammatory option for treatment of Atopic Dermatitis. This study aimed to evaluate the efficacy of superoxidised hydrogel as an adjunct treatment in improving symptoms and signs of mild to moderate AD, hence improving patient’s quality of life compared to moisturising treatment with aqueous cream. Methodology. This was a single centre, prospective, parallel, investigator-blinded clinical study in adult with mild to moderate Atopic dermatitis. Subjects were given super-oxidised hydrogel or aqueous cream (1:1) three times a day to areas affected by atopic dermatitis for 2 weeks. A change of assessment score (EASI and subjective SCORAD) and quality of life score (DLQI) from baseline was determined at week 1 and week 2. Results. A total of 60 patients with mean ageSD of 28.607.770 were enrolled. Study showed that treated area of AD improved in both treatment arms. Both treatments showed reduction of mean in all efficacy scores and DLQI scores from baseline to week 2. The effect was not statistically significant between the two arms. This suggest that super-oxidised hydrogel was comparable to aqueous cream as a moisturiser. There was no mean significant difference in terms of the hydrocortisone cream usage. Two subjects in aqueous cream group reported mild self-limiting side effects. Conclusion. Super-oxidised hydrogel is beneficial as treatment for atopic dermatitis in improving local signs assessed by EASI score, and its symptom mainly the pruritis. It is safe and should be considered as an alternative moisturiser. A larger study population is required to look at its efficacy after longer period of usage.
format	Thesis
qualification_level	Master's degree
author	Mustapa Albakari, Nabia Idaam
author_facet	Mustapa Albakari, Nabia Idaam
author_sort	Mustapa Albakari, Nabia Idaam
title	The efficacy of Super-oxidised Hydrogel versus Aqueous Cream in treatment of mild to moderate Atopic Dermatitis / Nabia Idaam Mustapa Albakari
title_short	The efficacy of Super-oxidised Hydrogel versus Aqueous Cream in treatment of mild to moderate Atopic Dermatitis / Nabia Idaam Mustapa Albakari
title_full	The efficacy of Super-oxidised Hydrogel versus Aqueous Cream in treatment of mild to moderate Atopic Dermatitis / Nabia Idaam Mustapa Albakari
title_fullStr	The efficacy of Super-oxidised Hydrogel versus Aqueous Cream in treatment of mild to moderate Atopic Dermatitis / Nabia Idaam Mustapa Albakari
title_full_unstemmed	The efficacy of Super-oxidised Hydrogel versus Aqueous Cream in treatment of mild to moderate Atopic Dermatitis / Nabia Idaam Mustapa Albakari
title_sort	efficacy of super-oxidised hydrogel versus aqueous cream in treatment of mild to moderate atopic dermatitis / nabia idaam mustapa albakari
granting_institution	Universiti Teknologi MARA (Kampus Sg. Buloh)
granting_department	Faculty of Medicine
publishDate	2019
url	https://ir.uitm.edu.my/id/eprint/29731/1/29731.pdf
_version_	1783734079511855104

The efficacy of Super-oxidised Hydrogel versus Aqueous Cream in treatment of mild to moderate Atopic Dermatitis / Nabia Idaam Mustapa Albakari

Similar Items