Establishment of an end-to-end 3D dosimetry system for radiotherapy of the brain using complementary metal oxide semiconductor-optical computed tomography (CMOS-OCT) and PRESAGE radiochromic polymer dosimeter / Muhammad Zamir Mohyedin
Advanced radiotherapy techniques require a three-dimensional (3D) dosimetry system that is capable of measuring the complex dose delivery accurately. Available dosimeters are mostly in one-dimensional (1D) and two-dimensional (2D), which have limitations to evaluate the volumetric dose distribution...
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my-uitm-ir.422222024-01-08T11:55:37Z Establishment of an end-to-end 3D dosimetry system for radiotherapy of the brain using complementary metal oxide semiconductor-optical computed tomography (CMOS-OCT) and PRESAGE radiochromic polymer dosimeter / Muhammad Zamir Mohyedin 2023 Mohyedin, Muhammad Zamir Radiation physics (General) Physical medicine. Physical therapy. Including massage, exercise, occupational therapy, hydrotherapy, phototherapy, radiotherapy, thermotherapy, electrotherapy Advanced radiotherapy techniques require a three-dimensional (3D) dosimetry system that is capable of measuring the complex dose delivery accurately. Available dosimeters are mostly in one-dimensional (1D) and two-dimensional (2D), which have limitations to evaluate the volumetric dose distribution from the advanced radiotherapy techniques. This study attempts to establish an end-to-end 3D dosimetry system for radiotherapy of the brain using a PRESAGE dosimeter and an anthropomorphic phantom that is readout using a complementary metal oxide semiconductor-optical computed tomography (CMOS-OCT) system. The characterisation of the CMOS-OCT/PRESAGE system was performed by investigating the dose uniformity, linearity, dose-rate dependency and percentage depth dose (PDD). The dosimetric properties of PRESAGE measured by the CMOS-OCT system were investigated and compared with the external beam therapy (EBT) film. Ultraviolet-Visible (UV-Vis) spectroscopy was used to verify the optical density (OD) change measured by the CMOS-OCT system. It was found that the OD of PRESAGE measured by the CMOS-OCT system demonstrated a linear dose response with the R2 better than 0.984. The system shows dose rate independency from 100 to 800 cGy/min with a less than 3% variation. The system illustrated an excellent agreement of the PDD profile with the ionisation chamber. These characterisation results demonstrated that the CMOS-OCT/PRESAGE system has potential for radiotherapy dosimetry. The CMOS-OCT/PRESAGE system also illustrates good agreement with standard dosimeter (EBT films) and with standard measurement system (UV-Vis spectroscopy).The performance of the PRESAGE dosimeter was evaluated by investigating the dose response under room temperature (27° C), control temperature (3°C to 5°C), exposure to visible light, fading response, reusability and reproducibility for the complex radiotherapy dose delivery. The irradiation was performed using a linear accelerator at 6 MV and 10 MV photon beam energy. 2023 Thesis https://ir.uitm.edu.my/id/eprint/42222/ https://ir.uitm.edu.my/id/eprint/42222/7/42222.pdf text en public phd doctoral Universiti Teknologi MARA (UiTM) Faculty of Applied Sciences Abdul Rahman, Ahmad Taufek Mohd Zin, Mohd Hafiz Mahat, Muzamir |
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Universiti Teknologi MARA |
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English |
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Abdul Rahman, Ahmad Taufek Mohd Zin, Mohd Hafiz Mahat, Muzamir |
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Radiation physics (General) Radiation physics (General) |
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Radiation physics (General) Radiation physics (General) Mohyedin, Muhammad Zamir Establishment of an end-to-end 3D dosimetry system for radiotherapy of the brain using complementary metal oxide semiconductor-optical computed tomography (CMOS-OCT) and PRESAGE radiochromic polymer dosimeter / Muhammad Zamir Mohyedin |
description |
Advanced radiotherapy techniques require a three-dimensional (3D) dosimetry system that is capable of measuring the complex dose delivery accurately. Available dosimeters are mostly in one-dimensional (1D) and two-dimensional (2D), which have limitations to evaluate the volumetric dose distribution from the advanced radiotherapy techniques. This study attempts to establish an end-to-end 3D dosimetry system for radiotherapy of the brain using a PRESAGE dosimeter and an anthropomorphic phantom that is readout using a complementary metal oxide semiconductor-optical computed tomography (CMOS-OCT) system. The characterisation of the CMOS-OCT/PRESAGE system was performed by investigating the dose uniformity, linearity, dose-rate dependency and percentage depth dose (PDD). The dosimetric properties of PRESAGE measured by the CMOS-OCT system were investigated and compared with the external beam therapy (EBT) film. Ultraviolet-Visible (UV-Vis) spectroscopy was used to verify the optical density (OD) change measured by the CMOS-OCT system. It was found that the OD of PRESAGE measured by the CMOS-OCT system demonstrated a linear dose response with the R2 better than 0.984. The system shows dose rate independency from 100 to 800 cGy/min with a less than 3% variation. The system illustrated an excellent agreement of the PDD profile with the ionisation chamber. These characterisation results demonstrated that the CMOS-OCT/PRESAGE system has potential for radiotherapy dosimetry. The CMOS-OCT/PRESAGE system also illustrates good agreement with standard dosimeter (EBT films) and with standard measurement system (UV-Vis spectroscopy).The performance of the PRESAGE dosimeter was evaluated by investigating the dose response under room temperature (27° C), control temperature (3°C to 5°C), exposure to visible light, fading response, reusability and reproducibility for the complex radiotherapy dose delivery. The irradiation was performed using a linear accelerator at 6 MV and 10 MV photon beam energy. |
format |
Thesis |
qualification_name |
Doctor of Philosophy (PhD.) |
qualification_level |
Doctorate |
author |
Mohyedin, Muhammad Zamir |
author_facet |
Mohyedin, Muhammad Zamir |
author_sort |
Mohyedin, Muhammad Zamir |
title |
Establishment of an end-to-end 3D dosimetry system for radiotherapy of the brain using complementary metal oxide semiconductor-optical computed tomography (CMOS-OCT) and PRESAGE radiochromic polymer dosimeter / Muhammad Zamir Mohyedin |
title_short |
Establishment of an end-to-end 3D dosimetry system for radiotherapy of the brain using complementary metal oxide semiconductor-optical computed tomography (CMOS-OCT) and PRESAGE radiochromic polymer dosimeter / Muhammad Zamir Mohyedin |
title_full |
Establishment of an end-to-end 3D dosimetry system for radiotherapy of the brain using complementary metal oxide semiconductor-optical computed tomography (CMOS-OCT) and PRESAGE radiochromic polymer dosimeter / Muhammad Zamir Mohyedin |
title_fullStr |
Establishment of an end-to-end 3D dosimetry system for radiotherapy of the brain using complementary metal oxide semiconductor-optical computed tomography (CMOS-OCT) and PRESAGE radiochromic polymer dosimeter / Muhammad Zamir Mohyedin |
title_full_unstemmed |
Establishment of an end-to-end 3D dosimetry system for radiotherapy of the brain using complementary metal oxide semiconductor-optical computed tomography (CMOS-OCT) and PRESAGE radiochromic polymer dosimeter / Muhammad Zamir Mohyedin |
title_sort |
establishment of an end-to-end 3d dosimetry system for radiotherapy of the brain using complementary metal oxide semiconductor-optical computed tomography (cmos-oct) and presage radiochromic polymer dosimeter / muhammad zamir mohyedin |
granting_institution |
Universiti Teknologi MARA (UiTM) |
granting_department |
Faculty of Applied Sciences |
publishDate |
2023 |
url |
https://ir.uitm.edu.my/id/eprint/42222/7/42222.pdf |
_version_ |
1794191824189915136 |