Establishment of an end-to-end 3D dosimetry system for radiotherapy of the brain using complementary metal oxide semiconductor-optical computed tomography (CMOS-OCT) and PRESAGE radiochromic polymer dosimeter / Muhammad Zamir Mohyedin

Advanced radiotherapy techniques require a three-dimensional (3D) dosimetry system that is capable of measuring the complex dose delivery accurately. Available dosimeters are mostly in one-dimensional (1D) and two-dimensional (2D), which have limitations to evaluate the volumetric dose distribution...

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Main Author:	Mohyedin, Muhammad Zamir
Format:	Thesis
Language:	English
Published:	2023
Subjects:	Radiation physics (General)
Online Access:	https://ir.uitm.edu.my/id/eprint/42222/7/42222.pdf
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id	my-uitm-ir.42222
record_format	uketd_dc
spelling	my-uitm-ir.422222024-01-08T11:55:37Z Establishment of an end-to-end 3D dosimetry system for radiotherapy of the brain using complementary metal oxide semiconductor-optical computed tomography (CMOS-OCT) and PRESAGE radiochromic polymer dosimeter / Muhammad Zamir Mohyedin 2023 Mohyedin, Muhammad Zamir Radiation physics (General) Physical medicine. Physical therapy. Including massage, exercise, occupational therapy, hydrotherapy, phototherapy, radiotherapy, thermotherapy, electrotherapy Advanced radiotherapy techniques require a three-dimensional (3D) dosimetry system that is capable of measuring the complex dose delivery accurately. Available dosimeters are mostly in one-dimensional (1D) and two-dimensional (2D), which have limitations to evaluate the volumetric dose distribution from the advanced radiotherapy techniques. This study attempts to establish an end-to-end 3D dosimetry system for radiotherapy of the brain using a PRESAGE dosimeter and an anthropomorphic phantom that is readout using a complementary metal oxide semiconductor-optical computed tomography (CMOS-OCT) system. The characterisation of the CMOS-OCT/PRESAGE system was performed by investigating the dose uniformity, linearity, dose-rate dependency and percentage depth dose (PDD). The dosimetric properties of PRESAGE measured by the CMOS-OCT system were investigated and compared with the external beam therapy (EBT) film. Ultraviolet-Visible (UV-Vis) spectroscopy was used to verify the optical density (OD) change measured by the CMOS-OCT system. It was found that the OD of PRESAGE measured by the CMOS-OCT system demonstrated a linear dose response with the R2 better than 0.984. The system shows dose rate independency from 100 to 800 cGy/min with a less than 3% variation. The system illustrated an excellent agreement of the PDD profile with the ionisation chamber. These characterisation results demonstrated that the CMOS-OCT/PRESAGE system has potential for radiotherapy dosimetry. The CMOS-OCT/PRESAGE system also illustrates good agreement with standard dosimeter (EBT films) and with standard measurement system (UV-Vis spectroscopy).The performance of the PRESAGE dosimeter was evaluated by investigating the dose response under room temperature (27° C), control temperature (3°C to 5°C), exposure to visible light, fading response, reusability and reproducibility for the complex radiotherapy dose delivery. The irradiation was performed using a linear accelerator at 6 MV and 10 MV photon beam energy. 2023 Thesis https://ir.uitm.edu.my/id/eprint/42222/ https://ir.uitm.edu.my/id/eprint/42222/7/42222.pdf text en public phd doctoral Universiti Teknologi MARA (UiTM) Faculty of Applied Sciences Abdul Rahman, Ahmad Taufek Mohd Zin, Mohd Hafiz Mahat, Muzamir
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Abdul Rahman, Ahmad Taufek Mohd Zin, Mohd Hafiz Mahat, Muzamir
topic	Radiation physics (General) Radiation physics (General)
spellingShingle	Radiation physics (General) Radiation physics (General) Mohyedin, Muhammad Zamir Establishment of an end-to-end 3D dosimetry system for radiotherapy of the brain using complementary metal oxide semiconductor-optical computed tomography (CMOS-OCT) and PRESAGE radiochromic polymer dosimeter / Muhammad Zamir Mohyedin
description	Advanced radiotherapy techniques require a three-dimensional (3D) dosimetry system that is capable of measuring the complex dose delivery accurately. Available dosimeters are mostly in one-dimensional (1D) and two-dimensional (2D), which have limitations to evaluate the volumetric dose distribution from the advanced radiotherapy techniques. This study attempts to establish an end-to-end 3D dosimetry system for radiotherapy of the brain using a PRESAGE dosimeter and an anthropomorphic phantom that is readout using a complementary metal oxide semiconductor-optical computed tomography (CMOS-OCT) system. The characterisation of the CMOS-OCT/PRESAGE system was performed by investigating the dose uniformity, linearity, dose-rate dependency and percentage depth dose (PDD). The dosimetric properties of PRESAGE measured by the CMOS-OCT system were investigated and compared with the external beam therapy (EBT) film. Ultraviolet-Visible (UV-Vis) spectroscopy was used to verify the optical density (OD) change measured by the CMOS-OCT system. It was found that the OD of PRESAGE measured by the CMOS-OCT system demonstrated a linear dose response with the R2 better than 0.984. The system shows dose rate independency from 100 to 800 cGy/min with a less than 3% variation. The system illustrated an excellent agreement of the PDD profile with the ionisation chamber. These characterisation results demonstrated that the CMOS-OCT/PRESAGE system has potential for radiotherapy dosimetry. The CMOS-OCT/PRESAGE system also illustrates good agreement with standard dosimeter (EBT films) and with standard measurement system (UV-Vis spectroscopy).The performance of the PRESAGE dosimeter was evaluated by investigating the dose response under room temperature (27° C), control temperature (3°C to 5°C), exposure to visible light, fading response, reusability and reproducibility for the complex radiotherapy dose delivery. The irradiation was performed using a linear accelerator at 6 MV and 10 MV photon beam energy.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Mohyedin, Muhammad Zamir
author_facet	Mohyedin, Muhammad Zamir
author_sort	Mohyedin, Muhammad Zamir
title	Establishment of an end-to-end 3D dosimetry system for radiotherapy of the brain using complementary metal oxide semiconductor-optical computed tomography (CMOS-OCT) and PRESAGE radiochromic polymer dosimeter / Muhammad Zamir Mohyedin
title_short	Establishment of an end-to-end 3D dosimetry system for radiotherapy of the brain using complementary metal oxide semiconductor-optical computed tomography (CMOS-OCT) and PRESAGE radiochromic polymer dosimeter / Muhammad Zamir Mohyedin
title_full	Establishment of an end-to-end 3D dosimetry system for radiotherapy of the brain using complementary metal oxide semiconductor-optical computed tomography (CMOS-OCT) and PRESAGE radiochromic polymer dosimeter / Muhammad Zamir Mohyedin
title_fullStr	Establishment of an end-to-end 3D dosimetry system for radiotherapy of the brain using complementary metal oxide semiconductor-optical computed tomography (CMOS-OCT) and PRESAGE radiochromic polymer dosimeter / Muhammad Zamir Mohyedin
title_full_unstemmed	Establishment of an end-to-end 3D dosimetry system for radiotherapy of the brain using complementary metal oxide semiconductor-optical computed tomography (CMOS-OCT) and PRESAGE radiochromic polymer dosimeter / Muhammad Zamir Mohyedin
title_sort	establishment of an end-to-end 3d dosimetry system for radiotherapy of the brain using complementary metal oxide semiconductor-optical computed tomography (cmos-oct) and presage radiochromic polymer dosimeter / muhammad zamir mohyedin
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Applied Sciences
publishDate	2023
url	https://ir.uitm.edu.my/id/eprint/42222/7/42222.pdf
_version_	1794191824189915136

Establishment of an end-to-end 3D dosimetry system for radiotherapy of the brain using complementary metal oxide semiconductor-optical computed tomography (CMOS-OCT) and PRESAGE radiochromic polymer dosimeter / Muhammad Zamir Mohyedin

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