Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman

The behavior of rigid guluronic acid-rich (MG) and flexible mannuronic acid-rich (MC) alginate in controlling drug release responses of spray-dried microspheres against microwave was investigated using sodium diclofenac as model water-soluble drug. MC microspheres required a shorter period of micro...

Full description

Saved in:

Bibliographic Details
Main Author:	Radman, Ekha Mardziah
Format:	Thesis
Language:	English
Published:	2010
Subjects:	RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/4833/1/TM_EKHA%20MARDZIAH%20RADMAN%20PH%2010_5.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-uitm-ir.4833
record_format	uketd_dc
spelling	my-uitm-ir.48332018-08-30T04:30:37Z Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman 2010 Radman, Ekha Mardziah RS Pharmacy and materia medica The behavior of rigid guluronic acid-rich (MG) and flexible mannuronic acid-rich (MC) alginate in controlling drug release responses of spray-dried microspheres against microwave was investigated using sodium diclofenac as model water-soluble drug. MC microspheres required a shorter period of microwave irradiation to reduce drug release extent than MG microspheres. In response to microwave, the drug release profiles of 1:1 MG-MG microspheres resembled MC microspheres. The state of polymer-polymer and drug-polymer interaction via 0-H and/or N-H moiety of microspheres was affected by alginate chain flexibility under the influence of microwave. It then governed the drug release responses of microspheres. 2010 Thesis https://ir.uitm.edu.my/id/eprint/4833/ https://ir.uitm.edu.my/id/eprint/4833/1/TM_EKHA%20MARDZIAH%20RADMAN%20PH%2010_5.pdf text en public masters Universiti Teknologi MARA Faculty of Pharmacy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Radman, Ekha Mardziah Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman
description	The behavior of rigid guluronic acid-rich (MG) and flexible mannuronic acid-rich (MC) alginate in controlling drug release responses of spray-dried microspheres against microwave was investigated using sodium diclofenac as model water-soluble drug. MC microspheres required a shorter period of microwave irradiation to reduce drug release extent than MG microspheres. In response to microwave, the drug release profiles of 1:1 MG-MG microspheres resembled MC microspheres. The state of polymer-polymer and drug-polymer interaction via 0-H and/or N-H moiety of microspheres was affected by alginate chain flexibility under the influence of microwave. It then governed the drug release responses of microspheres.
format	Thesis
qualification_level	Master's degree
author	Radman, Ekha Mardziah
author_facet	Radman, Ekha Mardziah
author_sort	Radman, Ekha Mardziah
title	Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman
title_short	Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman
title_full	Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman
title_fullStr	Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman
title_full_unstemmed	Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman
title_sort	effects of microwave on drug release responses of spray-dried alginate microspheres / ekha mardziah radman
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Pharmacy
publishDate	2010
url	https://ir.uitm.edu.my/id/eprint/4833/1/TM_EKHA%20MARDZIAH%20RADMAN%20PH%2010_5.pdf
_version_	1783733111424548864

Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman

Similar Items