Assessment of Anticoagulant Activity of hexane extract of Parkia Speciosa Pericarp / Nik Haryanti Nik Ibrahim

Limitations of existing anticoagulants have led to the research for development of alternative anticoagulant agents such as by using herbal medicine. Parkia speciosa or stink bean is abundantly found in tropical regions like Malaysia, Indonesia, Thailand and Philippines. It was believed by the local...

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Main Author:	Nik Ibrahim, Nik Haryanti
Format:	Thesis
Language:	English
Published:	2017
Subjects:	Drugs and their actions Antibacterial agents
Online Access:	https://ir.uitm.edu.my/id/eprint/50187/1/50187.pdf
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id	my-uitm-ir.50187
record_format	uketd_dc
spelling	my-uitm-ir.501872021-09-08T08:36:18Z Assessment of Anticoagulant Activity of hexane extract of Parkia Speciosa Pericarp / Nik Haryanti Nik Ibrahim 2017 Nik Ibrahim, Nik Haryanti Drugs and their actions Antibacterial agents Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) Limitations of existing anticoagulants have led to the research for development of alternative anticoagulant agents such as by using herbal medicine. Parkia speciosa or stink bean is abundantly found in tropical regions like Malaysia, Indonesia, Thailand and Philippines. It was believed by the locals to have medical properties. Therefore, the present study was conducted to evaluate the potential of hexane extract of Parkia speciosa pericarp as an anticoagulant agent. The extract of Parkia speciosa pericarp prepared using hexane as an extraction solvent was screened for its anticoagulant activity. The pericarps were left to dry and transformed into powder form before being soaked in hexane for about 25 days using the exhaustive method. An in vitro coagulation assay of activated partial thromboplastin time (aPTT), prothrombin time (PT) and thrombin time (TT) was performed on control plasma spiked with different concentrations of extract (10, 20, 40, 80 and 160 µg/ml). It was found that hexane extract of Parkia speciosa pericarp had significant effect (p<0.05) only at 160µg/ml compared with control. Therefore, the present study showed that the extract of Parkia speciosa pericarp possess significant anticoagulant activities in vitro when used at concentration of 160 µg/ml. 2017 Thesis https://ir.uitm.edu.my/id/eprint/50187/ https://ir.uitm.edu.my/id/eprint/50187/1/50187.pdf text en public degree Universiti Teknologi Mara (Kampus Puncak Alam) Faculty of Health Sciences Mohamed, Emida
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Mohamed, Emida
topic	Drugs and their actions Antibacterial agents Drugs and their actions
spellingShingle	Drugs and their actions Antibacterial agents Drugs and their actions Nik Ibrahim, Nik Haryanti Assessment of Anticoagulant Activity of hexane extract of Parkia Speciosa Pericarp / Nik Haryanti Nik Ibrahim
description	Limitations of existing anticoagulants have led to the research for development of alternative anticoagulant agents such as by using herbal medicine. Parkia speciosa or stink bean is abundantly found in tropical regions like Malaysia, Indonesia, Thailand and Philippines. It was believed by the locals to have medical properties. Therefore, the present study was conducted to evaluate the potential of hexane extract of Parkia speciosa pericarp as an anticoagulant agent. The extract of Parkia speciosa pericarp prepared using hexane as an extraction solvent was screened for its anticoagulant activity. The pericarps were left to dry and transformed into powder form before being soaked in hexane for about 25 days using the exhaustive method. An in vitro coagulation assay of activated partial thromboplastin time (aPTT), prothrombin time (PT) and thrombin time (TT) was performed on control plasma spiked with different concentrations of extract (10, 20, 40, 80 and 160 µg/ml). It was found that hexane extract of Parkia speciosa pericarp had significant effect (p<0.05) only at 160µg/ml compared with control. Therefore, the present study showed that the extract of Parkia speciosa pericarp possess significant anticoagulant activities in vitro when used at concentration of 160 µg/ml.
format	Thesis
qualification_level	Bachelor degree
author	Nik Ibrahim, Nik Haryanti
author_facet	Nik Ibrahim, Nik Haryanti
author_sort	Nik Ibrahim, Nik Haryanti
title	Assessment of Anticoagulant Activity of hexane extract of Parkia Speciosa Pericarp / Nik Haryanti Nik Ibrahim
title_short	Assessment of Anticoagulant Activity of hexane extract of Parkia Speciosa Pericarp / Nik Haryanti Nik Ibrahim
title_full	Assessment of Anticoagulant Activity of hexane extract of Parkia Speciosa Pericarp / Nik Haryanti Nik Ibrahim
title_fullStr	Assessment of Anticoagulant Activity of hexane extract of Parkia Speciosa Pericarp / Nik Haryanti Nik Ibrahim
title_full_unstemmed	Assessment of Anticoagulant Activity of hexane extract of Parkia Speciosa Pericarp / Nik Haryanti Nik Ibrahim
title_sort	assessment of anticoagulant activity of hexane extract of parkia speciosa pericarp / nik haryanti nik ibrahim
granting_institution	Universiti Teknologi Mara (Kampus Puncak Alam)
granting_department	Faculty of Health Sciences
publishDate	2017
url	https://ir.uitm.edu.my/id/eprint/50187/1/50187.pdf
_version_	1783734822978453504

Assessment of Anticoagulant Activity of hexane extract of Parkia Speciosa Pericarp / Nik Haryanti Nik Ibrahim

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