Anticoagulant activity of methanol extracts from parkia speciosa pericarp / Noraini Abdul Razak

Parkia speciosa is a medicinal plant that is used traditionally in several ailments of blood diseases. However, there is no report regarding its anticoagulant activities. So this study was conducted to evaluate the potential of methanol extract of Parkia speciosa pericarp as an anticoagulant. The an...

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Main Author:	Abdul Razak, Noraini
Format:	Thesis
Language:	English
Published:	2017
Subjects:	Drugs and their actions Fruit and fruit culture
Online Access:	https://ir.uitm.edu.my/id/eprint/50199/1/50199.pdf
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id	my-uitm-ir.50199
record_format	uketd_dc
spelling	my-uitm-ir.501992021-09-08T08:50:34Z Anticoagulant activity of methanol extracts from parkia speciosa pericarp / Noraini Abdul Razak 2017 Abdul Razak, Noraini Drugs and their actions Fruit and fruit culture Parkia speciosa is a medicinal plant that is used traditionally in several ailments of blood diseases. However, there is no report regarding its anticoagulant activities. So this study was conducted to evaluate the potential of methanol extract of Parkia speciosa pericarp as an anticoagulant. The anticoagulant activity will be evaluated by using PT, aPTT, and TT. Fresh pericarps were collected, cut into small pieces and air-dried for several days. Dried pericarp was grounded into powder. Maceration technique was applied for the extraction of Parkia speciosa pericarp. Methanol extraction (1:2) was done in a Schott bottle for 4 days at room temperature with occasional stirring and shaking. Extract was filtered using Whatman No.1 filter paper. The extract was then concentrated using rotary evaporator at low temperature and pressure as well as been dissolved in DMSO. Anticoagulant activity for PT, aPTT, and TT were tested at concentrations of 160, 80, 40, 20, and 10 µg/mL of extract. Analysis of result was performed using One way ANOVA followed with Dunnett t-test. For the aPTT test, the methanolic extract of Parkia speciosa pericarp was shown to contain anticoagulant and procoagulant properties. Significant results were obtained at concentrations of 10, 20, 80, and 160 µg/mL. As for PT and TT tests, significant results were shown only at concentration of 160 µg/mL. Hence, the methanolic extract of Parkia speciosa pericarp was shown to possessed anticoagulant (at higher concentration of extract) as well as procoagulant properties (at lower concentration of extract) 2017 Thesis https://ir.uitm.edu.my/id/eprint/50199/ https://ir.uitm.edu.my/id/eprint/50199/1/50199.pdf text en public degree Universiti Teknologi Mara (Kampus Puncak Alam) Faculty of Health Sciences Mohamed, Emida
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Mohamed, Emida
topic	Drugs and their actions Fruit and fruit culture
spellingShingle	Drugs and their actions Fruit and fruit culture Abdul Razak, Noraini Anticoagulant activity of methanol extracts from parkia speciosa pericarp / Noraini Abdul Razak
description	Parkia speciosa is a medicinal plant that is used traditionally in several ailments of blood diseases. However, there is no report regarding its anticoagulant activities. So this study was conducted to evaluate the potential of methanol extract of Parkia speciosa pericarp as an anticoagulant. The anticoagulant activity will be evaluated by using PT, aPTT, and TT. Fresh pericarps were collected, cut into small pieces and air-dried for several days. Dried pericarp was grounded into powder. Maceration technique was applied for the extraction of Parkia speciosa pericarp. Methanol extraction (1:2) was done in a Schott bottle for 4 days at room temperature with occasional stirring and shaking. Extract was filtered using Whatman No.1 filter paper. The extract was then concentrated using rotary evaporator at low temperature and pressure as well as been dissolved in DMSO. Anticoagulant activity for PT, aPTT, and TT were tested at concentrations of 160, 80, 40, 20, and 10 µg/mL of extract. Analysis of result was performed using One way ANOVA followed with Dunnett t-test. For the aPTT test, the methanolic extract of Parkia speciosa pericarp was shown to contain anticoagulant and procoagulant properties. Significant results were obtained at concentrations of 10, 20, 80, and 160 µg/mL. As for PT and TT tests, significant results were shown only at concentration of 160 µg/mL. Hence, the methanolic extract of Parkia speciosa pericarp was shown to possessed anticoagulant (at higher concentration of extract) as well as procoagulant properties (at lower concentration of extract)
format	Thesis
qualification_level	Bachelor degree
author	Abdul Razak, Noraini
author_facet	Abdul Razak, Noraini
author_sort	Abdul Razak, Noraini
title	Anticoagulant activity of methanol extracts from parkia speciosa pericarp / Noraini Abdul Razak
title_short	Anticoagulant activity of methanol extracts from parkia speciosa pericarp / Noraini Abdul Razak
title_full	Anticoagulant activity of methanol extracts from parkia speciosa pericarp / Noraini Abdul Razak
title_fullStr	Anticoagulant activity of methanol extracts from parkia speciosa pericarp / Noraini Abdul Razak
title_full_unstemmed	Anticoagulant activity of methanol extracts from parkia speciosa pericarp / Noraini Abdul Razak
title_sort	anticoagulant activity of methanol extracts from parkia speciosa pericarp / noraini abdul razak
granting_institution	Universiti Teknologi Mara (Kampus Puncak Alam)
granting_department	Faculty of Health Sciences
publishDate	2017
url	https://ir.uitm.edu.my/id/eprint/50199/1/50199.pdf
_version_	1783734824589066240

Anticoagulant activity of methanol extracts from parkia speciosa pericarp / Noraini Abdul Razak

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