Sequence analysis and homology modeling of mouse TRPCl, TRPC4 & TRPC5 channels / Ruzifaizura Ahmad Kalam

Transient receptor potential (TRP) channels are involved in the perception of a wide range of physical and chemical stimuli, including temperature and osmolarity changes, light, pain, touch, taste and pheromones, and in the initiation of cellular responses there upon. Knowing the structure of these...

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Main Author:	Ahmad Kalam, Ruzifaizura
Format:	Thesis
Language:	English
Published:	2012
Subjects:	Neurophysiology and neuropsychology
Online Access:	https://ir.uitm.edu.my/id/eprint/66816/1/66816.pdf
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id	my-uitm-ir.66816
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spelling	my-uitm-ir.668162022-09-15T07:52:40Z Sequence analysis and homology modeling of mouse TRPCl, TRPC4 & TRPC5 channels / Ruzifaizura Ahmad Kalam 2012 Ahmad Kalam, Ruzifaizura Neurophysiology and neuropsychology Senses. Sensation. Sense organs Transient receptor potential (TRP) channels are involved in the perception of a wide range of physical and chemical stimuli, including temperature and osmolarity changes, light, pain, touch, taste and pheromones, and in the initiation of cellular responses there upon. Knowing the structure of these importantly discover receptor proteins are crucial since these proteins also responsible for many diseases such as breast cancer, prostate cancer and cardiovascular disease. The absence of the three dimensional structure of the transient receptor potential channels (TRPCs) drove us to construct the homology modeling based on its similarity with one protein of the known structure as template protein. This prediction method would allow users to rapidly use generated in silico protein models in all the contexts where today only experimental structures provide a solid basis: structure-based drug design, analysis of protein function, interactions, antigenic behavior, and rational design of proteins with increased stability or novel functions. Furthermore, protein modeling is the only way to obtain structural information if experimental techniques fail. Many proteins are simply too large for NMR analysis and cannot be crystallized for X-ray diffraction, where homology modeling can overcome this limitation. The model generated can then be used for further research in determining the exact properties and function of TRPC1, TRPC4 and TRPC5. 2012 Thesis https://ir.uitm.edu.my/id/eprint/66816/ https://ir.uitm.edu.my/id/eprint/66816/1/66816.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Pharmacy Jusoh, Siti Azma
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Jusoh, Siti Azma
topic	Neurophysiology and neuropsychology Neurophysiology and neuropsychology
spellingShingle	Neurophysiology and neuropsychology Neurophysiology and neuropsychology Ahmad Kalam, Ruzifaizura Sequence analysis and homology modeling of mouse TRPCl, TRPC4 & TRPC5 channels / Ruzifaizura Ahmad Kalam
description	Transient receptor potential (TRP) channels are involved in the perception of a wide range of physical and chemical stimuli, including temperature and osmolarity changes, light, pain, touch, taste and pheromones, and in the initiation of cellular responses there upon. Knowing the structure of these importantly discover receptor proteins are crucial since these proteins also responsible for many diseases such as breast cancer, prostate cancer and cardiovascular disease. The absence of the three dimensional structure of the transient receptor potential channels (TRPCs) drove us to construct the homology modeling based on its similarity with one protein of the known structure as template protein. This prediction method would allow users to rapidly use generated in silico protein models in all the contexts where today only experimental structures provide a solid basis: structure-based drug design, analysis of protein function, interactions, antigenic behavior, and rational design of proteins with increased stability or novel functions. Furthermore, protein modeling is the only way to obtain structural information if experimental techniques fail. Many proteins are simply too large for NMR analysis and cannot be crystallized for X-ray diffraction, where homology modeling can overcome this limitation. The model generated can then be used for further research in determining the exact properties and function of TRPC1, TRPC4 and TRPC5.
format	Thesis
qualification_level	Bachelor degree
author	Ahmad Kalam, Ruzifaizura
author_facet	Ahmad Kalam, Ruzifaizura
author_sort	Ahmad Kalam, Ruzifaizura
title	Sequence analysis and homology modeling of mouse TRPCl, TRPC4 & TRPC5 channels / Ruzifaizura Ahmad Kalam
title_short	Sequence analysis and homology modeling of mouse TRPCl, TRPC4 & TRPC5 channels / Ruzifaizura Ahmad Kalam
title_full	Sequence analysis and homology modeling of mouse TRPCl, TRPC4 & TRPC5 channels / Ruzifaizura Ahmad Kalam
title_fullStr	Sequence analysis and homology modeling of mouse TRPCl, TRPC4 & TRPC5 channels / Ruzifaizura Ahmad Kalam
title_full_unstemmed	Sequence analysis and homology modeling of mouse TRPCl, TRPC4 & TRPC5 channels / Ruzifaizura Ahmad Kalam
title_sort	sequence analysis and homology modeling of mouse trpcl, trpc4 & trpc5 channels / ruzifaizura ahmad kalam
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Pharmacy
publishDate	2012
url	https://ir.uitm.edu.my/id/eprint/66816/1/66816.pdf
_version_	1783735642003341312

Sequence analysis and homology modeling of mouse TRPCl, TRPC4 & TRPC5 channels / Ruzifaizura Ahmad Kalam

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