Biochemical profile and histological analysis of ICR mice treated with selamectin / Wan Aimuni Wan Zakaria

This study was designed to determine the effects of a single-dose of topical administration of selamectin on the biochemical profile and histological structure of kidney and liver of laboratory mice. All 60 mice with the average weight of 25mg were divided into 10 groups where 5 groups were treatmen...

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Main Author:	Wan Zakaria, Wan Aimuni
Format:	Thesis
Language:	English
Published:	2012
Subjects:	Diseases due to parasites Drugs and their actions
Online Access:	https://ir.uitm.edu.my/id/eprint/66819/1/66819.pdf
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id	my-uitm-ir.66819
record_format	uketd_dc
spelling	my-uitm-ir.668192022-09-15T08:07:39Z Biochemical profile and histological analysis of ICR mice treated with selamectin / Wan Aimuni Wan Zakaria 2012 Wan Zakaria, Wan Aimuni Diseases due to parasites Drugs and their actions This study was designed to determine the effects of a single-dose of topical administration of selamectin on the biochemical profile and histological structure of kidney and liver of laboratory mice. All 60 mice with the average weight of 25mg were divided into 10 groups where 5 groups were treatment groups and the other 5 groups were control groups. Ectoparasites identification was done on Day-1. Blood sampling and organ collections from one control group and one treatment group were obtained on Day-2, Day-7, Day-21 and Day-28. The organs collected were kidney and liver and slide were prepared to observe the structure of kidney and liver. Selamectin was found to be safe in mice because from the Mann-Whitney U test in all the biochemical parameters (ALT, AST, Creatinine and Urea), p-value were greater than 0.05. For histological analysis, there were also no significant changes observed in the structure of liver and kidney for both control and treatment groups. Therefore, future study is needed to investigate the long term effects of selamectin on laboratory mice. 2012 Thesis https://ir.uitm.edu.my/id/eprint/66819/ https://ir.uitm.edu.my/id/eprint/66819/1/66819.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Pharmacy Shia, John Kwong Siew
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Shia, John Kwong Siew
topic	Diseases due to parasites Drugs and their actions
spellingShingle	Diseases due to parasites Drugs and their actions Wan Zakaria, Wan Aimuni Biochemical profile and histological analysis of ICR mice treated with selamectin / Wan Aimuni Wan Zakaria
description	This study was designed to determine the effects of a single-dose of topical administration of selamectin on the biochemical profile and histological structure of kidney and liver of laboratory mice. All 60 mice with the average weight of 25mg were divided into 10 groups where 5 groups were treatment groups and the other 5 groups were control groups. Ectoparasites identification was done on Day-1. Blood sampling and organ collections from one control group and one treatment group were obtained on Day-2, Day-7, Day-21 and Day-28. The organs collected were kidney and liver and slide were prepared to observe the structure of kidney and liver. Selamectin was found to be safe in mice because from the Mann-Whitney U test in all the biochemical parameters (ALT, AST, Creatinine and Urea), p-value were greater than 0.05. For histological analysis, there were also no significant changes observed in the structure of liver and kidney for both control and treatment groups. Therefore, future study is needed to investigate the long term effects of selamectin on laboratory mice.
format	Thesis
qualification_level	Bachelor degree
author	Wan Zakaria, Wan Aimuni
author_facet	Wan Zakaria, Wan Aimuni
author_sort	Wan Zakaria, Wan Aimuni
title	Biochemical profile and histological analysis of ICR mice treated with selamectin / Wan Aimuni Wan Zakaria
title_short	Biochemical profile and histological analysis of ICR mice treated with selamectin / Wan Aimuni Wan Zakaria
title_full	Biochemical profile and histological analysis of ICR mice treated with selamectin / Wan Aimuni Wan Zakaria
title_fullStr	Biochemical profile and histological analysis of ICR mice treated with selamectin / Wan Aimuni Wan Zakaria
title_full_unstemmed	Biochemical profile and histological analysis of ICR mice treated with selamectin / Wan Aimuni Wan Zakaria
title_sort	biochemical profile and histological analysis of icr mice treated with selamectin / wan aimuni wan zakaria
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Pharmacy
publishDate	2012
url	https://ir.uitm.edu.my/id/eprint/66819/1/66819.pdf
_version_	1783735642788724736

Biochemical profile and histological analysis of ICR mice treated with selamectin / Wan Aimuni Wan Zakaria

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