Relevance of peroxisome proliferator-activated receptor-gamma in obesity / Ili Nursafra Tedin Ng

The peroxisome proliferator-activated receptor gamma (PPAR-y) plays an important role in the regulation of the transcription of several genes involved in adipocyte differentiation, lipid oxidation, glucose and lipid metabolism, insulin sensitivity, angiogenesis and inflammation. The Pro12Ala polymor...

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Main Author:	Tedin Ng, Ili Nursafra
Format:	Thesis
Language:	English
Published:	2013
Subjects:	Human genetics Obesity
Online Access:	https://ir.uitm.edu.my/id/eprint/72186/1/72186.pdf
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id	my-uitm-ir.72186
record_format	uketd_dc
spelling	my-uitm-ir.721862024-01-04T06:24:12Z Relevance of peroxisome proliferator-activated receptor-gamma in obesity / Ili Nursafra Tedin Ng 2013 Tedin Ng, Ili Nursafra Human genetics Obesity The peroxisome proliferator-activated receptor gamma (PPAR-y) plays an important role in the regulation of the transcription of several genes involved in adipocyte differentiation, lipid oxidation, glucose and lipid metabolism, insulin sensitivity, angiogenesis and inflammation. The Pro12Ala polymorphism in PPAR-y2 is frequently associated with type-2 diabetes while its association with obesity in different populations are contradictory. Its association with obesity among Caucasians, Mediterranean and Asian population are widely studied; however, no study was conducted among the Malaysian Malays. This study investigates the influence of Pro 12Ala missense mutation of PPAR- y on the risk of obesity and obesity-related phenotypes in Malaysian Malays which include effects of dietary fat intake and the level of physical activity with BMI. We recruited 40 obese and 40 lean individuals aged from 18 to 65 years old and conducted anthropometrical examinations for the calculation of Body Mass Index (BMI) and waist-hip ratio (WHR). Body fat mass as well as fat percentage was also measured using bioelectrical impedance analyser TANITA® SC-330 (T ANITA Corp, Japan). Indication for the level of physical activity was derived from self-administered long form International Physical Activity Questionnaire (IPAQ) while 24-hour dietary recall was conducted by trained dieticians for the calculation of dietary fat intake. 2013 Thesis https://ir.uitm.edu.my/id/eprint/72186/ https://ir.uitm.edu.my/id/eprint/72186/1/72186.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Medicine Ahmad, Arninuddin Teh, Lay Kek
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Ahmad, Arninuddin Teh, Lay Kek
topic	Human genetics Obesity
spellingShingle	Human genetics Obesity Tedin Ng, Ili Nursafra Relevance of peroxisome proliferator-activated receptor-gamma in obesity / Ili Nursafra Tedin Ng
description	The peroxisome proliferator-activated receptor gamma (PPAR-y) plays an important role in the regulation of the transcription of several genes involved in adipocyte differentiation, lipid oxidation, glucose and lipid metabolism, insulin sensitivity, angiogenesis and inflammation. The Pro12Ala polymorphism in PPAR-y2 is frequently associated with type-2 diabetes while its association with obesity in different populations are contradictory. Its association with obesity among Caucasians, Mediterranean and Asian population are widely studied; however, no study was conducted among the Malaysian Malays. This study investigates the influence of Pro 12Ala missense mutation of PPAR- y on the risk of obesity and obesity-related phenotypes in Malaysian Malays which include effects of dietary fat intake and the level of physical activity with BMI. We recruited 40 obese and 40 lean individuals aged from 18 to 65 years old and conducted anthropometrical examinations for the calculation of Body Mass Index (BMI) and waist-hip ratio (WHR). Body fat mass as well as fat percentage was also measured using bioelectrical impedance analyser TANITA® SC-330 (T ANITA Corp, Japan). Indication for the level of physical activity was derived from self-administered long form International Physical Activity Questionnaire (IPAQ) while 24-hour dietary recall was conducted by trained dieticians for the calculation of dietary fat intake.
format	Thesis
qualification_level	Bachelor degree
author	Tedin Ng, Ili Nursafra
author_facet	Tedin Ng, Ili Nursafra
author_sort	Tedin Ng, Ili Nursafra
title	Relevance of peroxisome proliferator-activated receptor-gamma in obesity / Ili Nursafra Tedin Ng
title_short	Relevance of peroxisome proliferator-activated receptor-gamma in obesity / Ili Nursafra Tedin Ng
title_full	Relevance of peroxisome proliferator-activated receptor-gamma in obesity / Ili Nursafra Tedin Ng
title_fullStr	Relevance of peroxisome proliferator-activated receptor-gamma in obesity / Ili Nursafra Tedin Ng
title_full_unstemmed	Relevance of peroxisome proliferator-activated receptor-gamma in obesity / Ili Nursafra Tedin Ng
title_sort	relevance of peroxisome proliferator-activated receptor-gamma in obesity / ili nursafra tedin ng
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Medicine
publishDate	2013
url	https://ir.uitm.edu.my/id/eprint/72186/1/72186.pdf
_version_	1794191891148832768

Relevance of peroxisome proliferator-activated receptor-gamma in obesity / Ili Nursafra Tedin Ng

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