Altered calcium to magnesium ratio and calpain activity as pharmacological target of anticataract effect of magnesium taurate / Sarah Diyana Saad
Cataract is a condition characterized by decrease in visual acuity due to cloudiness of the lens. Magnesium deficiency coupled with lenticular ATP depletion impairs the membrane ATPases functions leads to calcium homeostasis disruption. Consequently, high calcium level leads to activation of calcium...
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| Format: | Thesis |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://ir.uitm.edu.my/id/eprint/72217/1/72217.pdf |
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| Summary: | Cataract is a condition characterized by decrease in visual acuity due to cloudiness of the lens. Magnesium deficiency coupled with lenticular ATP depletion impairs the membrane ATPases functions leads to calcium homeostasis disruption. Consequently, high calcium level leads to activation of calcium-dependent calpain which responsible in denaturation of the lenticular crystallin protein. Previous study proved that aqeous Mg taurate tends to delay the onset and progression of cataract in vivo and in vitro however, the ocular bioavailability was low. Therefore, we conducted an in vivo study to evaluate the anti-cataract effect of liposomal formulation of Mg taurate in the galactose-induced cataract model. |
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