Altered calcium to magnesium ratio and calpain activity as pharmacological target of anticataract effect of magnesium taurate / Sarah Diyana Saad

Cataract is a condition characterized by decrease in visual acuity due to cloudiness of the lens. Magnesium deficiency coupled with lenticular ATP depletion impairs the membrane ATPases functions leads to calcium homeostasis disruption. Consequently, high calcium level leads to activation of calcium...

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Main Author:	Saad, Sarah Diyana
Format:	Thesis
Language:	English
Published:	2013
Subjects:	Magnesium RE Ophthalmology
Online Access:	https://ir.uitm.edu.my/id/eprint/72217/1/72217.pdf
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id	my-uitm-ir.72217
record_format	uketd_dc
spelling	my-uitm-ir.722172024-01-04T07:53:12Z Altered calcium to magnesium ratio and calpain activity as pharmacological target of anticataract effect of magnesium taurate / Sarah Diyana Saad 2013 Saad, Sarah Diyana Magnesium RE Ophthalmology Cataract is a condition characterized by decrease in visual acuity due to cloudiness of the lens. Magnesium deficiency coupled with lenticular ATP depletion impairs the membrane ATPases functions leads to calcium homeostasis disruption. Consequently, high calcium level leads to activation of calcium-dependent calpain which responsible in denaturation of the lenticular crystallin protein. Previous study proved that aqeous Mg taurate tends to delay the onset and progression of cataract in vivo and in vitro however, the ocular bioavailability was low. Therefore, we conducted an in vivo study to evaluate the anti-cataract effect of liposomal formulation of Mg taurate in the galactose-induced cataract model. 2013 Thesis https://ir.uitm.edu.my/id/eprint/72217/ https://ir.uitm.edu.my/id/eprint/72217/1/72217.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Medicine Iezhitsa, Igor Nikolayevich
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Iezhitsa, Igor Nikolayevich
topic	Magnesium RE Ophthalmology
spellingShingle	Magnesium RE Ophthalmology Saad, Sarah Diyana Altered calcium to magnesium ratio and calpain activity as pharmacological target of anticataract effect of magnesium taurate / Sarah Diyana Saad
description	Cataract is a condition characterized by decrease in visual acuity due to cloudiness of the lens. Magnesium deficiency coupled with lenticular ATP depletion impairs the membrane ATPases functions leads to calcium homeostasis disruption. Consequently, high calcium level leads to activation of calcium-dependent calpain which responsible in denaturation of the lenticular crystallin protein. Previous study proved that aqeous Mg taurate tends to delay the onset and progression of cataract in vivo and in vitro however, the ocular bioavailability was low. Therefore, we conducted an in vivo study to evaluate the anti-cataract effect of liposomal formulation of Mg taurate in the galactose-induced cataract model.
format	Thesis
qualification_level	Bachelor degree
author	Saad, Sarah Diyana
author_facet	Saad, Sarah Diyana
author_sort	Saad, Sarah Diyana
title	Altered calcium to magnesium ratio and calpain activity as pharmacological target of anticataract effect of magnesium taurate / Sarah Diyana Saad
title_short	Altered calcium to magnesium ratio and calpain activity as pharmacological target of anticataract effect of magnesium taurate / Sarah Diyana Saad
title_full	Altered calcium to magnesium ratio and calpain activity as pharmacological target of anticataract effect of magnesium taurate / Sarah Diyana Saad
title_fullStr	Altered calcium to magnesium ratio and calpain activity as pharmacological target of anticataract effect of magnesium taurate / Sarah Diyana Saad
title_full_unstemmed	Altered calcium to magnesium ratio and calpain activity as pharmacological target of anticataract effect of magnesium taurate / Sarah Diyana Saad
title_sort	altered calcium to magnesium ratio and calpain activity as pharmacological target of anticataract effect of magnesium taurate / sarah diyana saad
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Medicine
publishDate	2013
url	https://ir.uitm.edu.my/id/eprint/72217/1/72217.pdf
_version_	1794191892377763840

Altered calcium to magnesium ratio and calpain activity as pharmacological target of anticataract effect of magnesium taurate / Sarah Diyana Saad

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