The effects of probiotic supplementation on glycaemic control, gut microbiota and other diabetes-related outcomes in type 2 Diabetes Mellitus patients / Fatin Umirah Mahamad Hazaham

Type 2 Diabetes Mellitus (T2DM), one of the most prevailing non-communicable diseases, is associated with high mortality and morbidity. It appears that alteration of gut microbiota (i.e., dysbiosis) could be responsible for the development and progression of T2DM. In order to better understand the p...

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Main Author:	Mahamad Hazaham, Fatin Umirah
Format:	Thesis
Language:	English
Published:	2022
Subjects:	Diabetes Mellitus Drugs and their actions
Online Access:	https://ir.uitm.edu.my/id/eprint/76712/1/76712.pdf
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id	my-uitm-ir.76712
record_format	uketd_dc
spelling	my-uitm-ir.767122023-05-29T04:42:53Z The effects of probiotic supplementation on glycaemic control, gut microbiota and other diabetes-related outcomes in type 2 Diabetes Mellitus patients / Fatin Umirah Mahamad Hazaham 2022 Mahamad Hazaham, Fatin Umirah Diabetes Mellitus Drugs and their actions Type 2 Diabetes Mellitus (T2DM), one of the most prevailing non-communicable diseases, is associated with high mortality and morbidity. It appears that alteration of gut microbiota (i.e., dysbiosis) could be responsible for the development and progression of T2DM. In order to better understand the pathogenesis of T2DM, a systematic review was first conducted to critically appraise existing evidence of differential gut microbiota composition between T2DM and control groups as well as its correlation with metabolic parameters. Lactobacilli were found to predominate the gut of T2DM patients and correlated positively with glycaemic parameters. In contrast, butyrate producers dominated the gut of control group which can be seen by their negative correlations with glycaemic parameters. The shortlisted studies varied in terms of sample size, study design and population, which hindered meaningful general conclusions to be made. A case-control study was then designed and carried out to investigate the differential gut microbiota between T2DM patients and healthy control at local setting. 2022 Thesis https://ir.uitm.edu.my/id/eprint/76712/ https://ir.uitm.edu.my/id/eprint/76712/1/76712.pdf text en public phd doctoral Universiti Teknologi MARA (UiTM) Faculty of Pharmacy Ramasamy, Kalavathy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Ramasamy, Kalavathy
topic	Diabetes Mellitus Drugs and their actions
spellingShingle	Diabetes Mellitus Drugs and their actions Mahamad Hazaham, Fatin Umirah The effects of probiotic supplementation on glycaemic control, gut microbiota and other diabetes-related outcomes in type 2 Diabetes Mellitus patients / Fatin Umirah Mahamad Hazaham
description	Type 2 Diabetes Mellitus (T2DM), one of the most prevailing non-communicable diseases, is associated with high mortality and morbidity. It appears that alteration of gut microbiota (i.e., dysbiosis) could be responsible for the development and progression of T2DM. In order to better understand the pathogenesis of T2DM, a systematic review was first conducted to critically appraise existing evidence of differential gut microbiota composition between T2DM and control groups as well as its correlation with metabolic parameters. Lactobacilli were found to predominate the gut of T2DM patients and correlated positively with glycaemic parameters. In contrast, butyrate producers dominated the gut of control group which can be seen by their negative correlations with glycaemic parameters. The shortlisted studies varied in terms of sample size, study design and population, which hindered meaningful general conclusions to be made. A case-control study was then designed and carried out to investigate the differential gut microbiota between T2DM patients and healthy control at local setting.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Mahamad Hazaham, Fatin Umirah
author_facet	Mahamad Hazaham, Fatin Umirah
author_sort	Mahamad Hazaham, Fatin Umirah
title	The effects of probiotic supplementation on glycaemic control, gut microbiota and other diabetes-related outcomes in type 2 Diabetes Mellitus patients / Fatin Umirah Mahamad Hazaham
title_short	The effects of probiotic supplementation on glycaemic control, gut microbiota and other diabetes-related outcomes in type 2 Diabetes Mellitus patients / Fatin Umirah Mahamad Hazaham
title_full	The effects of probiotic supplementation on glycaemic control, gut microbiota and other diabetes-related outcomes in type 2 Diabetes Mellitus patients / Fatin Umirah Mahamad Hazaham
title_fullStr	The effects of probiotic supplementation on glycaemic control, gut microbiota and other diabetes-related outcomes in type 2 Diabetes Mellitus patients / Fatin Umirah Mahamad Hazaham
title_full_unstemmed	The effects of probiotic supplementation on glycaemic control, gut microbiota and other diabetes-related outcomes in type 2 Diabetes Mellitus patients / Fatin Umirah Mahamad Hazaham
title_sort	effects of probiotic supplementation on glycaemic control, gut microbiota and other diabetes-related outcomes in type 2 diabetes mellitus patients / fatin umirah mahamad hazaham
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Pharmacy
publishDate	2022
url	https://ir.uitm.edu.my/id/eprint/76712/1/76712.pdf
_version_	1783736119359176704

The effects of probiotic supplementation on glycaemic control, gut microbiota and other diabetes-related outcomes in type 2 Diabetes Mellitus patients / Fatin Umirah Mahamad Hazaham

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