Kinetic behaviour of Christia vespertilionis oil in supercritical carbon dioxide / Izni Atikah Abd Hamid

Public interest in natural drugs has enormously increased in industrialized countries with expanding use of plants and herbal medicines. Recently, one of the plant herbs involves in curing cancer diseases has emerged and is recognized as Christia vespertilionis. Previously, Christia vespertilionis w...

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Main Author:	Abd Hamid, Izni Atikah
Format:	Thesis
Language:	English
Published:	2019
Subjects:	Biochemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/82813/1/82813.pdf
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id	my-uitm-ir.82813
record_format	uketd_dc
spelling	my-uitm-ir.828132024-02-02T07:41:29Z Kinetic behaviour of Christia vespertilionis oil in supercritical carbon dioxide / Izni Atikah Abd Hamid 2019 Abd Hamid, Izni Atikah Biochemistry Public interest in natural drugs has enormously increased in industrialized countries with expanding use of plants and herbal medicines. Recently, one of the plant herbs involves in curing cancer diseases has emerged and is recognized as Christia vespertilionis. Previously, Christia vespertilionis was extracted using solvent extraction such as hexane, methanol and dichloromethane. Unfortunately, conventional solvent was toxic, unsafe and might contaminate the extract of the product especially product that were used for medicinal purposes. Therefore, extraction of Christia vespertilionis plant using pure supercritical carbon dioxide (SC-CO2) without any co-solvent was assessed for the first time. The aim of the research is to investigate kinetic behaviour of Christia vespertilionis oil in SC-CO2 fluid in terms of extraction yield, oil’s solubility, mass transfer and phytocompound’s characterization. The effect of extraction parameter such as temperatures (40 to 85°C) and pressures (276 to 414 bar) of SC-CO2 extraction on yield, solubility and mass transfer of Christia vespertilionis oil were evaluated. Extracted oil was then analysed under gas chromatography mass spectrometry according to their retention indices and mass spectra. Experimental data of solubility was correlated using four empirical of density-based models i.e. Chrastil (1982), del Valle and Aguilera (1988), Adachi and Lu (1983), and Sparks et al. (2008) models. Furthermore, behaviour of extraction yield and mass transfer of oil in solid and fluid phases was modeled using a Lack’s plug flow model by Sovova (1994). Results demonstrated that the oil yield and solubility were highly dependent on the extraction pressure. 2019 Thesis https://ir.uitm.edu.my/id/eprint/82813/ https://ir.uitm.edu.my/id/eprint/82813/1/82813.pdf text en public phd doctoral Universiti Teknologi MARA (UiTM) Faculty of Chemical Engineering Ismail, Norhuda
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Ismail, Norhuda
topic	Biochemistry
spellingShingle	Biochemistry Abd Hamid, Izni Atikah Kinetic behaviour of Christia vespertilionis oil in supercritical carbon dioxide / Izni Atikah Abd Hamid
description	Public interest in natural drugs has enormously increased in industrialized countries with expanding use of plants and herbal medicines. Recently, one of the plant herbs involves in curing cancer diseases has emerged and is recognized as Christia vespertilionis. Previously, Christia vespertilionis was extracted using solvent extraction such as hexane, methanol and dichloromethane. Unfortunately, conventional solvent was toxic, unsafe and might contaminate the extract of the product especially product that were used for medicinal purposes. Therefore, extraction of Christia vespertilionis plant using pure supercritical carbon dioxide (SC-CO2) without any co-solvent was assessed for the first time. The aim of the research is to investigate kinetic behaviour of Christia vespertilionis oil in SC-CO2 fluid in terms of extraction yield, oil’s solubility, mass transfer and phytocompound’s characterization. The effect of extraction parameter such as temperatures (40 to 85°C) and pressures (276 to 414 bar) of SC-CO2 extraction on yield, solubility and mass transfer of Christia vespertilionis oil were evaluated. Extracted oil was then analysed under gas chromatography mass spectrometry according to their retention indices and mass spectra. Experimental data of solubility was correlated using four empirical of density-based models i.e. Chrastil (1982), del Valle and Aguilera (1988), Adachi and Lu (1983), and Sparks et al. (2008) models. Furthermore, behaviour of extraction yield and mass transfer of oil in solid and fluid phases was modeled using a Lack’s plug flow model by Sovova (1994). Results demonstrated that the oil yield and solubility were highly dependent on the extraction pressure.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Abd Hamid, Izni Atikah
author_facet	Abd Hamid, Izni Atikah
author_sort	Abd Hamid, Izni Atikah
title	Kinetic behaviour of Christia vespertilionis oil in supercritical carbon dioxide / Izni Atikah Abd Hamid
title_short	Kinetic behaviour of Christia vespertilionis oil in supercritical carbon dioxide / Izni Atikah Abd Hamid
title_full	Kinetic behaviour of Christia vespertilionis oil in supercritical carbon dioxide / Izni Atikah Abd Hamid
title_fullStr	Kinetic behaviour of Christia vespertilionis oil in supercritical carbon dioxide / Izni Atikah Abd Hamid
title_full_unstemmed	Kinetic behaviour of Christia vespertilionis oil in supercritical carbon dioxide / Izni Atikah Abd Hamid
title_sort	kinetic behaviour of christia vespertilionis oil in supercritical carbon dioxide / izni atikah abd hamid
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Chemical Engineering
publishDate	2019
url	https://ir.uitm.edu.my/id/eprint/82813/1/82813.pdf
_version_	1794191947618844672

Kinetic behaviour of Christia vespertilionis oil in supercritical carbon dioxide / Izni Atikah Abd Hamid

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