Synthetic approach towards anti-inflammatory agent, daibucarboline a and its derivatives via tetrahydro- β-carboline intermediates / Nur Ain Nabilah Ash’ari

β-Carbolines, belonging to the class of indole alkaloids, were isolated from wild Syrian rue (Peganum harmala), which is common in Iran. Over the past few decades, the synthesis of β-carbolines has elicited much interest due to its wide pharmaceutical and biological applications. For instance, one o...

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Main Author:	Ash’ari, Nur Ain Nabilah
Format:	Thesis
Language:	English
Published:	2023
Subjects:	QD Chemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/88803/1/88803.pdf
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id	my-uitm-ir.88803
record_format	uketd_dc
spelling	my-uitm-ir.888032023-12-26T07:24:49Z Synthetic approach towards anti-inflammatory agent, daibucarboline a and its derivatives via tetrahydro- β-carboline intermediates / Nur Ain Nabilah Ash’ari 2023 Ash’ari, Nur Ain Nabilah QD Chemistry β-Carbolines, belonging to the class of indole alkaloids, were isolated from wild Syrian rue (Peganum harmala), which is common in Iran. Over the past few decades, the synthesis of β-carbolines has elicited much interest due to its wide pharmaceutical and biological applications. For instance, one of their many derivatives, the daibucarboline A 1, is proved to demonstrate interesting anti-inflammatory activity upon tested using iNOS assay with the IC50 value of 18.41 μM. However, literature survey reveals there is no report found on the synthesis of daibucarboline A 1 in addition to limited works on its isolated compound. Thus, we described herein the synthetic approach towards daibucarboline A 1 and its derivatives by using different substituted indoles and aldehydes/glyoxal. The first part is the chemical studies towards the intermediates and derivatives of daibucarboline A 1 using tryptamine 29 as the starting material with different substituted benzaldehydes 30-42 to afford a series of key 1-substituted tetrahydro-β-carboline intermediates 43-55 in 20-95 % yields. 2023 Thesis https://ir.uitm.edu.my/id/eprint/88803/ https://ir.uitm.edu.my/id/eprint/88803/1/88803.pdf text en public masters Universiti Teknologi MARA (UiTM) Faculty of Applied Sciences Pungot, Noor Hidayah
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Pungot, Noor Hidayah
topic	QD Chemistry
spellingShingle	QD Chemistry Ash’ari, Nur Ain Nabilah Synthetic approach towards anti-inflammatory agent, daibucarboline a and its derivatives via tetrahydro- β-carboline intermediates / Nur Ain Nabilah Ash’ari
description	β-Carbolines, belonging to the class of indole alkaloids, were isolated from wild Syrian rue (Peganum harmala), which is common in Iran. Over the past few decades, the synthesis of β-carbolines has elicited much interest due to its wide pharmaceutical and biological applications. For instance, one of their many derivatives, the daibucarboline A 1, is proved to demonstrate interesting anti-inflammatory activity upon tested using iNOS assay with the IC50 value of 18.41 μM. However, literature survey reveals there is no report found on the synthesis of daibucarboline A 1 in addition to limited works on its isolated compound. Thus, we described herein the synthetic approach towards daibucarboline A 1 and its derivatives by using different substituted indoles and aldehydes/glyoxal. The first part is the chemical studies towards the intermediates and derivatives of daibucarboline A 1 using tryptamine 29 as the starting material with different substituted benzaldehydes 30-42 to afford a series of key 1-substituted tetrahydro-β-carboline intermediates 43-55 in 20-95 % yields.
format	Thesis
qualification_level	Master's degree
author	Ash’ari, Nur Ain Nabilah
author_facet	Ash’ari, Nur Ain Nabilah
author_sort	Ash’ari, Nur Ain Nabilah
title	Synthetic approach towards anti-inflammatory agent, daibucarboline a and its derivatives via tetrahydro- β-carboline intermediates / Nur Ain Nabilah Ash’ari
title_short	Synthetic approach towards anti-inflammatory agent, daibucarboline a and its derivatives via tetrahydro- β-carboline intermediates / Nur Ain Nabilah Ash’ari
title_full	Synthetic approach towards anti-inflammatory agent, daibucarboline a and its derivatives via tetrahydro- β-carboline intermediates / Nur Ain Nabilah Ash’ari
title_fullStr	Synthetic approach towards anti-inflammatory agent, daibucarboline a and its derivatives via tetrahydro- β-carboline intermediates / Nur Ain Nabilah Ash’ari
title_full_unstemmed	Synthetic approach towards anti-inflammatory agent, daibucarboline a and its derivatives via tetrahydro- β-carboline intermediates / Nur Ain Nabilah Ash’ari
title_sort	synthetic approach towards anti-inflammatory agent, daibucarboline a and its derivatives via tetrahydro- β-carboline intermediates / nur ain nabilah ash’ari
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Applied Sciences
publishDate	2023
url	https://ir.uitm.edu.my/id/eprint/88803/1/88803.pdf
_version_	1794192165013815296

Synthetic approach towards anti-inflammatory agent, daibucarboline a and its derivatives via tetrahydro- β-carboline intermediates / Nur Ain Nabilah Ash’ari

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