Synthetic approach towards anti-inflammatory agent, daibucarboline a and its derivatives via tetrahydro- β-carboline intermediates / Nur Ain Nabilah Ash’ari
β-Carbolines, belonging to the class of indole alkaloids, were isolated from wild Syrian rue (Peganum harmala), which is common in Iran. Over the past few decades, the synthesis of β-carbolines has elicited much interest due to its wide pharmaceutical and biological applications. For instance, one o...
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my-uitm-ir.888032023-12-26T07:24:49Z Synthetic approach towards anti-inflammatory agent, daibucarboline a and its derivatives via tetrahydro- β-carboline intermediates / Nur Ain Nabilah Ash’ari 2023 Ash’ari, Nur Ain Nabilah QD Chemistry β-Carbolines, belonging to the class of indole alkaloids, were isolated from wild Syrian rue (Peganum harmala), which is common in Iran. Over the past few decades, the synthesis of β-carbolines has elicited much interest due to its wide pharmaceutical and biological applications. For instance, one of their many derivatives, the daibucarboline A 1, is proved to demonstrate interesting anti-inflammatory activity upon tested using iNOS assay with the IC50 value of 18.41 μM. However, literature survey reveals there is no report found on the synthesis of daibucarboline A 1 in addition to limited works on its isolated compound. Thus, we described herein the synthetic approach towards daibucarboline A 1 and its derivatives by using different substituted indoles and aldehydes/glyoxal. The first part is the chemical studies towards the intermediates and derivatives of daibucarboline A 1 using tryptamine 29 as the starting material with different substituted benzaldehydes 30-42 to afford a series of key 1-substituted tetrahydro-β-carboline intermediates 43-55 in 20-95 % yields. 2023 Thesis https://ir.uitm.edu.my/id/eprint/88803/ https://ir.uitm.edu.my/id/eprint/88803/1/88803.pdf text en public masters Universiti Teknologi MARA (UiTM) Faculty of Applied Sciences Pungot, Noor Hidayah |
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Universiti Teknologi MARA |
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UiTM Institutional Repository |
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English |
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Pungot, Noor Hidayah |
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QD Chemistry |
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QD Chemistry Ash’ari, Nur Ain Nabilah Synthetic approach towards anti-inflammatory agent, daibucarboline a and its derivatives via tetrahydro- β-carboline intermediates / Nur Ain Nabilah Ash’ari |
description |
β-Carbolines, belonging to the class of indole alkaloids, were isolated from wild Syrian rue (Peganum harmala), which is common in Iran. Over the past few decades, the synthesis of β-carbolines has elicited much interest due to its wide pharmaceutical and biological applications. For instance, one of their many derivatives, the daibucarboline A 1, is proved to demonstrate interesting anti-inflammatory activity upon tested using iNOS assay with the IC50 value of 18.41 μM. However, literature survey reveals there is no report found on the synthesis of daibucarboline A 1 in addition to limited works on its isolated compound. Thus, we described herein the synthetic approach towards daibucarboline A 1 and its derivatives by using different substituted indoles and aldehydes/glyoxal. The first part is the chemical studies towards the intermediates and derivatives of daibucarboline A 1 using tryptamine 29 as the starting material with different substituted benzaldehydes 30-42 to afford a series of key 1-substituted tetrahydro-β-carboline intermediates 43-55 in 20-95 % yields. |
format |
Thesis |
qualification_level |
Master's degree |
author |
Ash’ari, Nur Ain Nabilah |
author_facet |
Ash’ari, Nur Ain Nabilah |
author_sort |
Ash’ari, Nur Ain Nabilah |
title |
Synthetic approach towards anti-inflammatory agent, daibucarboline a and its derivatives via tetrahydro- β-carboline intermediates / Nur Ain Nabilah Ash’ari |
title_short |
Synthetic approach towards anti-inflammatory agent, daibucarboline a and its derivatives via tetrahydro- β-carboline intermediates / Nur Ain Nabilah Ash’ari |
title_full |
Synthetic approach towards anti-inflammatory agent, daibucarboline a and its derivatives via tetrahydro- β-carboline intermediates / Nur Ain Nabilah Ash’ari |
title_fullStr |
Synthetic approach towards anti-inflammatory agent, daibucarboline a and its derivatives via tetrahydro- β-carboline intermediates / Nur Ain Nabilah Ash’ari |
title_full_unstemmed |
Synthetic approach towards anti-inflammatory agent, daibucarboline a and its derivatives via tetrahydro- β-carboline intermediates / Nur Ain Nabilah Ash’ari |
title_sort |
synthetic approach towards anti-inflammatory agent, daibucarboline a and its derivatives via tetrahydro- β-carboline intermediates / nur ain nabilah ash’ari |
granting_institution |
Universiti Teknologi MARA (UiTM) |
granting_department |
Faculty of Applied Sciences |
publishDate |
2023 |
url |
https://ir.uitm.edu.my/id/eprint/88803/1/88803.pdf |
_version_ |
1794192165013815296 |