Study to identify the novel neuromodulatory site of eurycoma longifolia jack (tongkat ali) in rat central nervous system (CNS) / Norhasimah Ali @ Yaakob

Eurycoma longifolia Jack is the herbal medicinal plant of South-East Asian origin, locally known as Tongkat Ali. Traditionally, it is used for its antimalarial, aphrodisiac, anti-diabetic, antimicrobial, anti-pyretic, anti-stress and anti-aging activities which have been proved scientifically. In Ma...

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Main Author:	Ali @ Yaakob, Norhasimah
Format:	Thesis
Language:	English
Published:	2017
Subjects:	Diseases of the musculoskeletal system
Online Access:	https://ir.uitm.edu.my/id/eprint/91233/1/91233.pdf
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id	my-uitm-ir.91233
record_format	uketd_dc
spelling	my-uitm-ir.912332024-05-21T07:23:50Z Study to identify the novel neuromodulatory site of eurycoma longifolia jack (tongkat ali) in rat central nervous system (CNS) / Norhasimah Ali @ Yaakob 2017 Ali @ Yaakob, Norhasimah Diseases of the musculoskeletal system Herbs. Herbal teas Eurycoma longifolia Jack is the herbal medicinal plant of South-East Asian origin, locally known as Tongkat Ali. Traditionally, it is used for its antimalarial, aphrodisiac, anti-diabetic, antimicrobial, anti-pyretic, anti-stress and anti-aging activities which have been proved scientifically. In Malaysia and South East Asia, demand for the therapeutic products application containing Tongkat Ali to treat male sexual dysfunction is increasing year by year. However, the neuro-anatomical functional site is still not known. The objective of this study is to localize the functional neuroanatomical site (s) of Eurycoma longifolia Jack extract in rat central nervous system (CNS) using immunohistochemistry technique. Control group of male Spraguedawley rats (six, weight 180-200 g) was received intraperitoneal injection (i.p.) of normal saline and experimental rats received i.p injection of Tongkat Ali (8mg/kg) of body weight. The expression of c-Fos protein immunoreactivity was detected in freeze frozen serial sections (40 μm) in dorsal and ventral horn of cervical spinal cord. C-Fos immunostaining was identified as black spot. Statistical analysis was performed using student t-test. P<0.001 was set as significant. Present study demonstrated that compare to control significant increased in number of c-Fos expression was detected in the sensory and motor nucleus of the spinal cord. To our knowledge, this is the first report in localization the functional sites of Tongkat Ali in rat motor and sensory nucleus. Result indicates that Tongkat Ali may have neuromodulatory function in motor and sensory nucleus. Further study is essential to investigate the therapeutic effect of Tongkat Ali in motor (e.g., temporomandibular) and sensory system (e.g., pain) disorders. 2017 Thesis https://ir.uitm.edu.my/id/eprint/91233/ https://ir.uitm.edu.my/id/eprint/91233/1/91233.pdf text en public masters Universiti Teknologi MARA (UiTM) Faculty of Dentistry Jamil, Kazi Ahsan
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Jamil, Kazi Ahsan
topic	Diseases of the musculoskeletal system Diseases of the musculoskeletal system
spellingShingle	Diseases of the musculoskeletal system Diseases of the musculoskeletal system Ali @ Yaakob, Norhasimah Study to identify the novel neuromodulatory site of eurycoma longifolia jack (tongkat ali) in rat central nervous system (CNS) / Norhasimah Ali @ Yaakob
description	Eurycoma longifolia Jack is the herbal medicinal plant of South-East Asian origin, locally known as Tongkat Ali. Traditionally, it is used for its antimalarial, aphrodisiac, anti-diabetic, antimicrobial, anti-pyretic, anti-stress and anti-aging activities which have been proved scientifically. In Malaysia and South East Asia, demand for the therapeutic products application containing Tongkat Ali to treat male sexual dysfunction is increasing year by year. However, the neuro-anatomical functional site is still not known. The objective of this study is to localize the functional neuroanatomical site (s) of Eurycoma longifolia Jack extract in rat central nervous system (CNS) using immunohistochemistry technique. Control group of male Spraguedawley rats (six, weight 180-200 g) was received intraperitoneal injection (i.p.) of normal saline and experimental rats received i.p injection of Tongkat Ali (8mg/kg) of body weight. The expression of c-Fos protein immunoreactivity was detected in freeze frozen serial sections (40 μm) in dorsal and ventral horn of cervical spinal cord. C-Fos immunostaining was identified as black spot. Statistical analysis was performed using student t-test. P<0.001 was set as significant. Present study demonstrated that compare to control significant increased in number of c-Fos expression was detected in the sensory and motor nucleus of the spinal cord. To our knowledge, this is the first report in localization the functional sites of Tongkat Ali in rat motor and sensory nucleus. Result indicates that Tongkat Ali may have neuromodulatory function in motor and sensory nucleus. Further study is essential to investigate the therapeutic effect of Tongkat Ali in motor (e.g., temporomandibular) and sensory system (e.g., pain) disorders.
format	Thesis
qualification_level	Master's degree
author	Ali @ Yaakob, Norhasimah
author_facet	Ali @ Yaakob, Norhasimah
author_sort	Ali @ Yaakob, Norhasimah
title	Study to identify the novel neuromodulatory site of eurycoma longifolia jack (tongkat ali) in rat central nervous system (CNS) / Norhasimah Ali @ Yaakob
title_short	Study to identify the novel neuromodulatory site of eurycoma longifolia jack (tongkat ali) in rat central nervous system (CNS) / Norhasimah Ali @ Yaakob
title_full	Study to identify the novel neuromodulatory site of eurycoma longifolia jack (tongkat ali) in rat central nervous system (CNS) / Norhasimah Ali @ Yaakob
title_fullStr	Study to identify the novel neuromodulatory site of eurycoma longifolia jack (tongkat ali) in rat central nervous system (CNS) / Norhasimah Ali @ Yaakob
title_full_unstemmed	Study to identify the novel neuromodulatory site of eurycoma longifolia jack (tongkat ali) in rat central nervous system (CNS) / Norhasimah Ali @ Yaakob
title_sort	study to identify the novel neuromodulatory site of eurycoma longifolia jack (tongkat ali) in rat central nervous system (cns) / norhasimah ali @ yaakob
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Dentistry
publishDate	2017
url	https://ir.uitm.edu.my/id/eprint/91233/1/91233.pdf
_version_	1804889833499262976

Study to identify the novel neuromodulatory site of eurycoma longifolia jack (tongkat ali) in rat central nervous system (CNS) / Norhasimah Ali @ Yaakob

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