Catheter-related blood stream infections caused by pathogenic bacteria in Hospital Queen Elizabeth Kota Kinabalu from 2009-2015

Blood stream infections (BSI) are the most common hospital-acquired infections. Rapid diagnosis and timely intervention are the key factors in preventing morbidity and mortality. With a mortality rate of 12% – 25%, CRBSI is the most serious nosocomial infections. This study investigated the antibiot...

Full description

Saved in:

Bibliographic Details
Main Author:	Jaistin Tamin
Format:	Thesis
Language:	English English
Published:	2018
Subjects:	RC870-923 Diseases of the genitourinary system Urology
Online Access:	https://eprints.ums.edu.my/id/eprint/41374/1/24%20PAGES.pdf https://eprints.ums.edu.my/id/eprint/41374/2/FULLTEXT.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-ums-ep.41374
record_format	uketd_dc
spelling	my-ums-ep.413742024-11-01T01:08:03Z Catheter-related blood stream infections caused by pathogenic bacteria in Hospital Queen Elizabeth Kota Kinabalu from 2009-2015 2018 Jaistin Tamin RC870-923 Diseases of the genitourinary system. Urology Blood stream infections (BSI) are the most common hospital-acquired infections. Rapid diagnosis and timely intervention are the key factors in preventing morbidity and mortality. With a mortality rate of 12% – 25%, CRBSI is the most serious nosocomial infections. This study investigated the antibiotic susceptibility patterns, the epidemiology of BSI, the frequency of BSI pathogens and multi-drug resistant isolates, the role of ethnic variation and the prevalence of BSI. Hospital laboratory records on BSI cases of patients admitted into the intensive care unit of Hospital Queen Elizabeth and Hospital Queen Elizabeth II from 2009 to 2015 were examined and analysed. Within this period, there were 11,420 BSI cases of which, a total of 1699 or 14.9% were CRBSI. Kadazan-Dusun (26.9%, 457) was the most common ethnic group encountered in the CRBSI cases, followed by Chinese (16.1%, 274) and Bajau (15.2%, 258). The frequency of CRBSI occurs mostly for in patients in the age group of 51 - 60 which was 22.4% (380), and the age groups of 41 – 50 (16.6%, 282) and 61 – 70 (17.6%, 299). The top five organisms were Coagulase Negative Staphylococcus (282, 17.2%), Staphylococcus aureus (177, 10.8%), Pseudomonas aeruginosa (124, 7.6%), Burkholderiapseudomallei (111, 6.8%) and Klebsiellapneumoniae(111, 6.8%). A significant uptrend in antibiotic resistant patterns were observed during the study period especially for Acinetobacterbaumanii which was gaining resistance to most of the antibiotics although still susceptible to Polymxin B. Klebsiellapneumoniae also noted with increasing resistance to cefoperazone (96.2%), cefuroxime (94.4%), ciprofloxacin (57.1%) and amoxicillinclavulanic acid (87.5%). In conclusion, there is a need to continually review the antibiograms pattern periodically to formulate the best empiric antimicrobial treatment. Since there is no known study was done in Sabah, it is expected that this study will provide a microbiological basis that may be relevant to BSI in Sabah, and these informations will help clinicians in initiating the empirical antibiotic therapy based on local data and thus preventing the emergence of multi-drugs resistant microorganisms. The study will also improve our understanding on the importance of CRBSI in the Sabah hospitals. 2018 Thesis https://eprints.ums.edu.my/id/eprint/41374/ https://eprints.ums.edu.my/id/eprint/41374/1/24%20PAGES.pdf text en public https://eprints.ums.edu.my/id/eprint/41374/2/FULLTEXT.pdf text en validuser masters Universiti Malaysia Sabah Fakulti Perubatan dan Sains Kesihatan
institution	Universiti Malaysia Sabah
collection	UMS Institutional Repository
language	English English
topic	RC870-923 Diseases of the genitourinary system Urology
spellingShingle	RC870-923 Diseases of the genitourinary system Urology Jaistin Tamin Catheter-related blood stream infections caused by pathogenic bacteria in Hospital Queen Elizabeth Kota Kinabalu from 2009-2015
description	Blood stream infections (BSI) are the most common hospital-acquired infections. Rapid diagnosis and timely intervention are the key factors in preventing morbidity and mortality. With a mortality rate of 12% – 25%, CRBSI is the most serious nosocomial infections. This study investigated the antibiotic susceptibility patterns, the epidemiology of BSI, the frequency of BSI pathogens and multi-drug resistant isolates, the role of ethnic variation and the prevalence of BSI. Hospital laboratory records on BSI cases of patients admitted into the intensive care unit of Hospital Queen Elizabeth and Hospital Queen Elizabeth II from 2009 to 2015 were examined and analysed. Within this period, there were 11,420 BSI cases of which, a total of 1699 or 14.9% were CRBSI. Kadazan-Dusun (26.9%, 457) was the most common ethnic group encountered in the CRBSI cases, followed by Chinese (16.1%, 274) and Bajau (15.2%, 258). The frequency of CRBSI occurs mostly for in patients in the age group of 51 - 60 which was 22.4% (380), and the age groups of 41 – 50 (16.6%, 282) and 61 – 70 (17.6%, 299). The top five organisms were Coagulase Negative Staphylococcus (282, 17.2%), Staphylococcus aureus (177, 10.8%), Pseudomonas aeruginosa (124, 7.6%), Burkholderiapseudomallei (111, 6.8%) and Klebsiellapneumoniae(111, 6.8%). A significant uptrend in antibiotic resistant patterns were observed during the study period especially for Acinetobacterbaumanii which was gaining resistance to most of the antibiotics although still susceptible to Polymxin B. Klebsiellapneumoniae also noted with increasing resistance to cefoperazone (96.2%), cefuroxime (94.4%), ciprofloxacin (57.1%) and amoxicillinclavulanic acid (87.5%). In conclusion, there is a need to continually review the antibiograms pattern periodically to formulate the best empiric antimicrobial treatment. Since there is no known study was done in Sabah, it is expected that this study will provide a microbiological basis that may be relevant to BSI in Sabah, and these informations will help clinicians in initiating the empirical antibiotic therapy based on local data and thus preventing the emergence of multi-drugs resistant microorganisms. The study will also improve our understanding on the importance of CRBSI in the Sabah hospitals.
format	Thesis
qualification_level	Master's degree
author	Jaistin Tamin
author_facet	Jaistin Tamin
author_sort	Jaistin Tamin
title	Catheter-related blood stream infections caused by pathogenic bacteria in Hospital Queen Elizabeth Kota Kinabalu from 2009-2015
title_short	Catheter-related blood stream infections caused by pathogenic bacteria in Hospital Queen Elizabeth Kota Kinabalu from 2009-2015
title_full	Catheter-related blood stream infections caused by pathogenic bacteria in Hospital Queen Elizabeth Kota Kinabalu from 2009-2015
title_fullStr	Catheter-related blood stream infections caused by pathogenic bacteria in Hospital Queen Elizabeth Kota Kinabalu from 2009-2015
title_full_unstemmed	Catheter-related blood stream infections caused by pathogenic bacteria in Hospital Queen Elizabeth Kota Kinabalu from 2009-2015
title_sort	catheter-related blood stream infections caused by pathogenic bacteria in hospital queen elizabeth kota kinabalu from 2009-2015
granting_institution	Universiti Malaysia Sabah
granting_department	Fakulti Perubatan dan Sains Kesihatan
publishDate	2018
url	https://eprints.ums.edu.my/id/eprint/41374/1/24%20PAGES.pdf https://eprints.ums.edu.my/id/eprint/41374/2/FULLTEXT.pdf
_version_	1818611398960218112

Catheter-related blood stream infections caused by pathogenic bacteria in Hospital Queen Elizabeth Kota Kinabalu from 2009-2015

Similar Items