Characterization and the process optimization encapsulated Morinda Citrifolia L. extract

Natural antioxidants are phytochemicals that neutralize free radicals, a damaging atom that trigger cells oxidation and destroys it. Morinda citnfolia L., or known as Mengkudu is proven to possess substantial quantity of antioxidant compound. Known to be sensitive to light, temperature, and oxygen,...

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Main Author:	Mohd Hafiz Abd Majid
Format:	Thesis
Language:	English
Published:	2011
Subjects:	TP Chemical technology
Online Access:	https://eprints.ums.edu.my/id/eprint/6666/1/mt0000000195.pdf
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spelling	my-ums-ep.66662017-10-11T07:38:06Z Characterization and the process optimization encapsulated Morinda Citrifolia L. extract 2011 Mohd Hafiz Abd Majid TP Chemical technology Natural antioxidants are phytochemicals that neutralize free radicals, a damaging atom that trigger cells oxidation and destroys it. Morinda citnfolia L., or known as Mengkudu is proven to possess substantial quantity of antioxidant compound. Known to be sensitive to light, temperature, and oxygen, the common preparation of Mengkudu may induce excess degradation of antioxidant compounds. Furthermore, direct intake of natural antioxidants may be at the disadvantage due to the instantaneous consumption effect which contributes to the loss of its catalytic properties. Hence, the encapsulation of the antioxidant compound is essential in order to prevent such outcomes. In this study, the microparticles were produced by spray drying method using mixture of carrageenanjxanthan gum and Mengkudu extract as the feed emulsion. The statistical response of RSM was used to assessed ANOVA and determine the optimum parameter of Mcore:Mwall ratio, inlet drying temperature and feed flow rate by studying the response of DPPH, total phenolic content (TPC), total flavonoid content (TFC) , encapsulation yield (EY), moisture content (MC), and particle size (PS). It has been shown that inlet drying temperature and Mcore:Mwall has significant effect on most of the responses studied, while feed flow rate only caused major effect on total phenolic and moisture content. Morphological study of carrageenans coated powders using SEM demonstrates round and smooth outer surface particles with a diameter of 6-13 Âµm. Whereas, xanthan gum coated powders formed more irregular particles with rough surface at a mean diameter of 15-32 Âµm. In vitro release study showed that Mengkudu microcapsules could regulate antioxidant release. This study shows that stable microparticles containing antioxidant can be produced in a single step by spray drying and may be helpful to the pharmaceutical application of Morinda Citrifolia L. 2011 Thesis https://eprints.ums.edu.my/id/eprint/6666/ https://eprints.ums.edu.my/id/eprint/6666/1/mt0000000195.pdf text en public masters Universiti Malaysia Sabah School of Engineering and Information Technology
institution	Universiti Malaysia Sabah
collection	UMS Institutional Repository
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Mohd Hafiz Abd Majid Characterization and the process optimization encapsulated Morinda Citrifolia L. extract
description	Natural antioxidants are phytochemicals that neutralize free radicals, a damaging atom that trigger cells oxidation and destroys it. Morinda citnfolia L., or known as Mengkudu is proven to possess substantial quantity of antioxidant compound. Known to be sensitive to light, temperature, and oxygen, the common preparation of Mengkudu may induce excess degradation of antioxidant compounds. Furthermore, direct intake of natural antioxidants may be at the disadvantage due to the instantaneous consumption effect which contributes to the loss of its catalytic properties. Hence, the encapsulation of the antioxidant compound is essential in order to prevent such outcomes. In this study, the microparticles were produced by spray drying method using mixture of carrageenanjxanthan gum and Mengkudu extract as the feed emulsion. The statistical response of RSM was used to assessed ANOVA and determine the optimum parameter of Mcore:Mwall ratio, inlet drying temperature and feed flow rate by studying the response of DPPH, total phenolic content (TPC), total flavonoid content (TFC) , encapsulation yield (EY), moisture content (MC), and particle size (PS). It has been shown that inlet drying temperature and Mcore:Mwall has significant effect on most of the responses studied, while feed flow rate only caused major effect on total phenolic and moisture content. Morphological study of carrageenans coated powders using SEM demonstrates round and smooth outer surface particles with a diameter of 6-13 Âµm. Whereas, xanthan gum coated powders formed more irregular particles with rough surface at a mean diameter of 15-32 Âµm. In vitro release study showed that Mengkudu microcapsules could regulate antioxidant release. This study shows that stable microparticles containing antioxidant can be produced in a single step by spray drying and may be helpful to the pharmaceutical application of Morinda Citrifolia L.
format	Thesis
qualification_level	Master's degree
author	Mohd Hafiz Abd Majid
author_facet	Mohd Hafiz Abd Majid
author_sort	Mohd Hafiz Abd Majid
title	Characterization and the process optimization encapsulated Morinda Citrifolia L. extract
title_short	Characterization and the process optimization encapsulated Morinda Citrifolia L. extract
title_full	Characterization and the process optimization encapsulated Morinda Citrifolia L. extract
title_fullStr	Characterization and the process optimization encapsulated Morinda Citrifolia L. extract
title_full_unstemmed	Characterization and the process optimization encapsulated Morinda Citrifolia L. extract
title_sort	characterization and the process optimization encapsulated morinda citrifolia l. extract
granting_institution	Universiti Malaysia Sabah
granting_department	School of Engineering and Information Technology
publishDate	2011
url	https://eprints.ums.edu.my/id/eprint/6666/1/mt0000000195.pdf
_version_	1747836327893663744

Characterization and the process optimization encapsulated Morinda Citrifolia L. extract

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