Development of an automated intelligent diagnostic system for tuberculosis detection based on sputum specimen

Tuberculosis (TB) is a highly infectious disease. TB diagnosis is usually done manually by microbiologist through microscopic examination of sputum specimen of TB patients for pulmonary TB diseases. However, this practice is time consuming and labour-intensive. Hence, it results in fatigue and work...

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Main Author: Rafikha Aliana, A. Raof
Format: Thesis
Language:English
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Online Access:http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/41291/1/Page%201-24.pdf
http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/41291/2/Full%20text.pdf
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spelling my-unimap-412912016-04-13T04:36:20Z Development of an automated intelligent diagnostic system for tuberculosis detection based on sputum specimen Rafikha Aliana, A. Raof Prof. Dr. Mohd. Yusoff Mashor Tuberculosis (TB) is a highly infectious disease. TB diagnosis is usually done manually by microbiologist through microscopic examination of sputum specimen of TB patients for pulmonary TB diseases. However, this practice is time consuming and labour-intensive. Hence, it results in fatigue and work overload to the microbiologists, thus reduces the diagnostic performance. This research involved in the development of automated intelligent diagnosis system for tuberculosis detection based on Ziehl-Neelsen sputum specimen. The system developed is also equipped with automatic capturing system for capturing sputum slide images automatically using 40X lens. Besides that, this study also suggested the combination of image processing technique with artificial neural network in creating a new procedure for diagnosing process of Ziehl-Neelsen sputum specimen. Image enhancement technique based on white balance and partial contrast method has been proposed. A new procedure for segmentation technique was also proposed based on the combination of kmeans clustering, 3 × 3 median filter and automated seed based region growing algorithm. The study also includes feature extraction where features such as size, colour and shape were chosen in classifying TB bacilli with the aid of artificial neural network. This research proposed to use HMLP network with MRPE algorithm for detection and classification of TB bacilli. The system is supposed to reduce the problems arise during the diagnosis of tuberculosis disease such as avoidance of eye fatigue to the microbiologist due to observing through the microscope eyepiece for a long period of time. It has been shown that the classification for sputum slide specimen for TB diagnosis produces good results with classification accuracy of more than 94%. These findings suggest the potential use of this software in diagnosing pulmonary TB disease. The conducted research has provided the platform for automated intelligent system to diagnose tuberculosis disease. Universiti Malaysia Perlis (UniMAP) 2014 Thesis en http://dspace.unimap.edu.my:80/xmlui/handle/123456789/41291 http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/41291/1/Page%201-24.pdf 1a0b5e5ffb305476098cd84b5a96f54d http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/41291/2/Full%20text.pdf 2e748161bbaabf1364075a789cfb8b99 http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/41291/3/license.txt 8a4605be74aa9ea9d79846c1fba20a33 Tuberculosis (TB) Infectious disease Tuberculosis Diagnostic System Sputum specimen Tuberculosis detection School of Computer and Communication Engineering
institution Universiti Malaysia Perlis
collection UniMAP Institutional Repository
language English
advisor Prof. Dr. Mohd. Yusoff Mashor
topic Tuberculosis (TB)
Infectious disease
Tuberculosis Diagnostic System
Sputum specimen
Tuberculosis detection
spellingShingle Tuberculosis (TB)
Infectious disease
Tuberculosis Diagnostic System
Sputum specimen
Tuberculosis detection
Rafikha Aliana, A. Raof
Development of an automated intelligent diagnostic system for tuberculosis detection based on sputum specimen
description Tuberculosis (TB) is a highly infectious disease. TB diagnosis is usually done manually by microbiologist through microscopic examination of sputum specimen of TB patients for pulmonary TB diseases. However, this practice is time consuming and labour-intensive. Hence, it results in fatigue and work overload to the microbiologists, thus reduces the diagnostic performance. This research involved in the development of automated intelligent diagnosis system for tuberculosis detection based on Ziehl-Neelsen sputum specimen. The system developed is also equipped with automatic capturing system for capturing sputum slide images automatically using 40X lens. Besides that, this study also suggested the combination of image processing technique with artificial neural network in creating a new procedure for diagnosing process of Ziehl-Neelsen sputum specimen. Image enhancement technique based on white balance and partial contrast method has been proposed. A new procedure for segmentation technique was also proposed based on the combination of kmeans clustering, 3 × 3 median filter and automated seed based region growing algorithm. The study also includes feature extraction where features such as size, colour and shape were chosen in classifying TB bacilli with the aid of artificial neural network. This research proposed to use HMLP network with MRPE algorithm for detection and classification of TB bacilli. The system is supposed to reduce the problems arise during the diagnosis of tuberculosis disease such as avoidance of eye fatigue to the microbiologist due to observing through the microscope eyepiece for a long period of time. It has been shown that the classification for sputum slide specimen for TB diagnosis produces good results with classification accuracy of more than 94%. These findings suggest the potential use of this software in diagnosing pulmonary TB disease. The conducted research has provided the platform for automated intelligent system to diagnose tuberculosis disease.
format Thesis
author Rafikha Aliana, A. Raof
author_facet Rafikha Aliana, A. Raof
author_sort Rafikha Aliana, A. Raof
title Development of an automated intelligent diagnostic system for tuberculosis detection based on sputum specimen
title_short Development of an automated intelligent diagnostic system for tuberculosis detection based on sputum specimen
title_full Development of an automated intelligent diagnostic system for tuberculosis detection based on sputum specimen
title_fullStr Development of an automated intelligent diagnostic system for tuberculosis detection based on sputum specimen
title_full_unstemmed Development of an automated intelligent diagnostic system for tuberculosis detection based on sputum specimen
title_sort development of an automated intelligent diagnostic system for tuberculosis detection based on sputum specimen
granting_institution Universiti Malaysia Perlis (UniMAP)
granting_department School of Computer and Communication Engineering
url http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/41291/1/Page%201-24.pdf
http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/41291/2/Full%20text.pdf
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