Development of silicon nanowire lab-on-chip microfluidics integrated biosensor for low concentration bio-molecules detection

Lab-on-chip fabricated with one-dimensional nanowires offer excellent electrical properties where bio molecular analysis at very low concentrations is becoming increasingly relevant for medical and research communities. Good number of techniques and promising results has been established for detecti...

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spelling my-unimap-727042021-11-18T08:21:28Z Development of silicon nanowire lab-on-chip microfluidics integrated biosensor for low concentration bio-molecules detection Uda, Hashim, Prof. Dr. Lab-on-chip fabricated with one-dimensional nanowires offer excellent electrical properties where bio molecular analysis at very low concentrations is becoming increasingly relevant for medical and research communities. Good number of techniques and promising results has been established for detecting small concentrations; however, for high-throughput measurements and label-free detection are still area of fresh investigation. Many research groups have reported high level of bio recognition by using semiconductor nanowire. The semiconductors silicon nanowire biosensor utilizes a Nano wire between two conducting materials. The nanowire has its atoms concentrated on its surface. Thus, any small changes in the charges present on the nanowire will cause a change in the flow of current. In this thesis, a simulation study coupled with experimental approach to explain the change in wire surface behavior as function of the surface charge. The linear behavior of the conductivity to increase the sensitivity of a semiconducting nanowire biosensor is ascertained. The silicon wire should be between 5 to 20nm to allow mean distance between atoms, the oxide should be as thin as possible for optimum surface integrity, and the functional layer should be thin and have a high dielectric constant. The ionic concentration of the electrolyte should be kept low in order to have a large Debye screening length. To confirm these theoretical results, Silicon nanowire of ≈ 15nm was fabricated using conventional photolithography coupled with dry etching process. To determine the capability of the device, it subjected to various pH values and to achieve this, the device is being operated based on the principle of Field Effect Transistor (FET). The surface of the device is hole dominated (p-type material). Universiti Malaysia Perlis (UniMAP) Thesis en http://dspace.unimap.edu.my:80/xmlui/handle/123456789/72704 http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/72704/3/license.txt 8a4605be74aa9ea9d79846c1fba20a33 http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/72704/1/Page%201-24.pdf b606769981c62849d9e074454419b298 http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/72704/2/Full%20text.pdf 184474f436bf8434186a75f1beb3b702 http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/72704/4/Tijani%20Adam.pdf c98bc8e5dd965cf97055683bd3af54ff Universiti Malaysia Perlis (UniMAP) Microfluids Nanowires Biosensors Nano Lab-On-Chip Nanotechnology Institute of Nano Electronic Engineering
institution Universiti Malaysia Perlis
collection UniMAP Institutional Repository
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advisor Uda, Hashim, Prof. Dr.
Umi Fazara, Md. Ali, Dr.
Mohamad Halim, Adb. Wahid, Dr.
Anuar, Mat Safar, Dr. Ir.
Mohd Shukry, Abdul Majid, Assoc. Prof. Ir. Dr.
Zainor Ridzuan, Yahya. Dr.
Salmah, Husseinsyah, Assoc. Prof. Ir. Dr.
Salmah, Husseinsyah, Assoc. Prof. Ir. Dr.
Mohd Irwan, Yusoff,Dr.
Mohd Azrik, Roslan, Dr.
Kamarudin, Husin, Datuk. Prof. Emeritus Dr.
Muzamir, Isa, Assoc. Prof. Dr.
Mohd Nashrul Fazli, Mohd Nasir, Dr.
Nik Noriman, Zulkepli, Dr.
Mohd Najmuddin, Mohd Hassan, Assoc. Prof. dr.
Shahrul Nizam, Yaakob, Assoc. Prof. Dr.
Muhammad Asri, Idris, Dr.
Muhammad Faiq, Abdullah
Mohd Noor, Ahmad, Dr.
Omg, Bi Lynn, Dr.
Azwan Iskandar, Azmi, Dr.
Zarina, Zakaria, Dr.
Khairul Azwan, Ismail, Assoc. Prof. Dr.
Syed Alwee Al Junid, Syed Junid, Prof. Dr.
Muhammad Zaini, Ahmad, Dr.
Mohd Noor, Ahmad, Prof. Dr.
Irwana Nainggolan, Dr.
Marliza, Mostapha@Zakaria
Nashrul Fazli, Mohd Nasir, Dr.
Sam Sung, Ting, Dr.
Sabira, Khatun, Prof. Dr.
Norainiza, Saud, Dr.
Wan Zuki Azman, Wan Muhamad
Kamarudin, Hussin, Datuk Prof. Dr.
Khor, Shing Fhan
Hariharan, Muthusamy, Dr.
Wan Khairunizam, Wan Ahmad, Assoc. Prof. Dr.
Rozyanty, Rahman, Dr.
Ali Yeon, Md. Shakaff, Prof. Dr.
Abdullah, Chik, Assoc. Prof.
Ali Yeon, Md. Shakaff, Prof. Dr.
Ali Yeon, Md. Shakaff, Prof. Dr.
R. Badlishah, Ahmad, Prof. Ir. Dr.
Md. Aminul, Islam, Prof. Dr.
Anuar, Mat Safar, Prof. Ir. Dr.
Rozyanty, Rahman, Dr.
Ragunathan, Santiagoo, Dr.
Sharifah Shahnaz, Syed Bakar, Dr.
Yusoff, Mashor, Prof. Dr.
Mohd Shukry, Abdul Majid, Assoc. Prof. Ir. Dr.
Mohd Khairuddin, Md. Arshad, Ir. Dr.
Mohd Mustafa Al Bakri, Abdullah, Assoc. Prof. Dr.
Mohd Afendi, Rojan, Dr.
Rosni, Bakar, Prof. Dr.
Uda, Hashim, Prof. Dr.
Md. Aminul, Islam, Assoc. Prof. Dr.
Sara Yasina, Yusuf, Dr.
Kamarudin, Hussin, Prof. Emeritus Dr.
Abadal-Salam Taha, Hussain, Dr.
Mohd Zulham Affandi, Mohd Zahid
Muhammad Irwanto, Misrun, Dr.
Teh, Pei Leng, Dr.
Rosni, Bakar, Prof. Dr.
Vithyacharan, Retnasamy, Dr.
Khairul Azwan, Ismail, Assoc. Prof. Dr.
Mohd Khairuddin, Md. Arshad, Ir. Dr.
Sam Sung, Ting, Dr.
Nor Fauziah, Zainudin
Norainiza, Saud, Dr.
Zuraidawani, Che Daud, Dr.
Phak Len, Eh Kan, Dr.
Mohd Faizal, Jamlos, Assoc. Prof. Dr.
Mohammad Iqbal, Omar, Assoc. Prof. Dr.
Mohd Shukry, Abdul Majid, Dr.
Mohd Shukry, Abdul Majid, Dr.
Muhammad Syarhabil, Ahmad, Assoc. Prof. Dr.
Sam Sung, Ting, Dr.
Norainiza, Saud, Dr.
Mohd Firdaus, Omar, Dr.
Mohd Faizal, Jamlos, Assoc. Prof. Ir. Dr.
Md. Mijanur, Rahman, Dr.
Nik Noriman, Zulkepli, Dr.
R. Badlishah, Ahmad, Prof. Dr.
Ali Yeon, Md. Shakaff, Prof. Dr.
Hilal Adnan, Fadhil
Che Mohd Ruzaidi, Ghazali, Assoc. Prof.
Nik Noriman, Zulkepli, Dr.
Salmah, Husseinsyah, Assoc. Prof. Ir. Dr.
Shafriza Nisha, Basah, Dr.
Kahtan S., Mohammed, Dr.
Hariharan, Muthusamy, Dr.
Ali Yeon, Md. Shakaff, Prof. Dr.
Hariharan, Muthusamy, Dr.
Ali Yeon, Md. Shakaff, Prof. Dr.
Abdul Hamid, Adom, Prof. Dr.
Wan Khairunizam, Wan Ahmad, Assoc. Prof. Dr.
Hariharan, Muthusamy, Dr.
Salmah, Husseinsyah, Assoc. Prof. Ir. Dr.
Kahtan S., Mohammed, Dr.
topic Microfluids
Nanowires
Biosensors
Nano Lab-On-Chip
Nanotechnology
Hematite
Solar energy
Photo-Anode film
Photo-electrochemical (PEC)
Photo-Anode film -- Design and construction
Hydrogen (H2)
Optical fiber communication
Optical communication
Optical data processing
Laser communication systems
Optical switches
Pressure transducers
Natural rubber
FBG sensor
Microelectromechanical systems
Optical fiber communication
Fibrous composites
Glass fibers
Composite materials
Napier fibres
Natural fiber
Spline theory
Information visualization
Curves
Surfaces
Computer graphics
Three-dimensional imaging
Shapes
Thermoplastics
Polyethylene
Polypropylene
Polymers
Recycled polypropylene (rPP)
Recycled high density polyethylene (rHDPE)
Polymer blends
Thermoplastic composites
Thermoplastics
Fillers (Materials)
Biocomposite
Cocoa pod husk (CPH)
Polypropylene (PP)
Photovoltaic power systems
Renewable energy sources
Heat -- Transmission
Gas air conditioning
Photovoltaic (PV)
Cooling system
Microgrids (Smart power grids)
Microgrid
Power sharing
Central controller
Fuzzy mathematics
Fuzzy logic
Kaolin
Concrete masonry
Bricks
Geopolymer masonry brick
Geopolymer
Electric insulators and insulation
Partial discharge (PD)
Artificial neural network (ANN)
Muscle
EMG signals
Electromyography (EMG)
Body posture
Solah
Rubber -- Recycling
Microfluids
Microfluids
Microfluids
Recycled rubber blends
Ethylene propylene diene monomer (EPDM)
Recycled acrylonitrile butadiene rubber (rNBR)
Greenhouse plants
Wireless sensor networks
Computer science
Greenhouse -- Monitoring and management system
Internet of Things (IoT)
Microfluids
Data encryption (Computer science)
Cryptography
Encryption
Self-consolidating concrete
Concrete
Limestone powder
Self-Compacting Concrete (SCC)
Fisheries
Fish feeds
Catfish
Fish Feed Nutrients
African catfish (Clarias gariepinus)
Polyanilines
Nanofibers
Ammonia
Nanostructured polyaniline (PANI)
Chemiresistor sensor
Vehicular ad hoc networks (Computer networks)
Vehicular Ad Hoc Networks (VANET)
Networks
Routing protocol
Polymeric composites
Fiber-reinforced plastics
Hybrid composites
Composites
Hybrid Fibre-Reinforced Polymer (FRP)
Cultivated mushroom
Pleurotus
Lyophilization
Pleurotus pulmonarius
Wound healing
Wounds and injuries
Hypertrophic scars
Headgear
Pressure garment
Code division multiple access
Optical communication
Optical Code-Division Multiple-Access System (OCDMA)
Noise
Optical network
Transformations (Mathematics)
Differential equations
Integral transforms
Ordinary differential Equations (ODEs)
Fuzzy Sumudu transform (FST)
Fuzzy numbers
Graphene
Microfluids
Antenna radiation patterns
Antennas (Electronics)
Graphene Oxide
Chitosan
Chitin
Polyethylene oxide
Graphite
Detectors
Composite materials
Cellulose -- Biodegradation
Coconut shell (CS)
Biocomposite films
Cellulose composites
Biocomposites
Tissue Scaffolds
Tissue engineering
Scaffolding
Starch
Dielectrics
nHA/starch
Biomedical engineering
Biodegradable plastics
Polyethylene
Biocomposites
Plastics
Rambutan peel
Blood sugar
Diabetes
Blood glucose
Diabetic patient
Ultra-wideband devices
Solder and soldering
Powder Metallurgy
Sintering
Soldering technology
Solders
Heuristic algorithms
Routing protocols (Computer network protocols)
Microfluids
Arc Routing Problem
Capacitated Arc Routing Problem (MCARP)
Aggregates (Building materials)
Inorganic Polymers
Mud volcanoes
Microfluids
Geopolymers
Lightweight aggregate
Electrolytes
Magnesium phosphate
Dielectrics
Liquid dielectrics
Optical glass
Hydrogel
Body mass index (BMI)
Obesity
Speech recognition
BMI prediction
Face detection
Emotion recognition
Intelligent real-time facial expression recognition system -- Design and construction
Intelligent real-time facial expression recognition system
Polymeric composites
Fibers
Kenaf
Hybrid composites
Composites
Natural fiber
Swarm intelligence
Robotics
Odour
Gas sensing
Gas source localization
Agricultural waste
Citric acid
Silica
Oil palm ash
Heat -- Transmission
Fire detection
Classifier
Automatic Fire Detection
Indoor Air Quality (IAQ)
Harumanis mango
Optical communication
Harumanis
Harumanis -- Quality inspection
Machine Vision
Detectors
Phishing
Network security
Phishing Detection System
Hotel industry
Tourism management
Brand image
Advertisement
Tourism -- Bangladesh
Wireless communication systems
Orthogonal Frequency-Division Multiplexing (OFDM)
Wireless
Foamed materials
Polyurethanes
Kenaf
Polyurethane foam (PUF)
Fibers
Kenaf fibers
Composites
Natural fiber
Polyethylene
Palm kernel shell (PKS)
Composites
Thermoplastic
Recycled acrylonitrile butadiene rubber (NBRr)
Polypropylene (PP)
Polyethylene
Bedpan
Thermoplastic
Polyvinyl Chloride
Polymer
Thalassemia
Red blood cells (RBC)
Image enhancement
Blood disease
Glass fibers
Glass fibre reinforced epoxy (GRE)
Pipes
Composites
Composite pipe
Wired glove system -- Design and construction
Wired glove system
GloveMAP
Dataglove
Power rectifier
Power Rectifier (P-i-N rectifier)
Diode
Polymeric composites
Geopolymers
Kaolin
Coating
Geopolymer coating
White clay
Biomedical materials
Hydrothermal
Bonded T-Joint
Adhesive joint
Hydrothermal effect
Organizational performance
Banking institutions -- Jordan
Accounting information systems (AIS)
Jordanian banking sector
Nanoparticles
Escherichia coli
Sensors
Escherichia coli O157:H7 (E.coli O157:H7) -- Detection
Stock exchange
Earnings management (EM)
Jordanian capital market
Corporate governance
Electrolytic reduction
Carbon dioxide
Formate
Cathode
Soil stabilization
Soil mechanics
Geopolymerization
Photovoltaic power generation
Renewable resource integration
Energy development
Renewable energy
Photovoltaic
Maximum Power Point Tracking (MPPT)
Concrete beams
Reinforced concrete
Reinforced concrete construction
Concrete
Ultra High Performance Concrete (UHPC)
Photovoltaic power systems
Wind power
Renewable energy sources
Photovoltaic cooling system
Wind power generation
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Photovoltaic power systems
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Renewable energy sources
Pattern recognition systems
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Optical communication
Computer network
Solder and soldering
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Solder
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Joints -- Range of motion
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spellingShingle Microfluids
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Transistor
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Microfluids
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Solder and soldering
Tin alloys
SnPb solders
Magnesium alloys
Powder Metallurgy
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Field programmable gate arrays
Antenna arrays
MIMO systems
Bacteria detection
Electric nose
Diabetic
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Composite Materials
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Fibrous composites
GRE composite pipes
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Phytochemicals
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Copper
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Joints -- Range of motion
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Tracking (Engineering)
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Copper alloys
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Crying in infants
Signal processing
Neural networks (Computer science)
Wavelets (Mathematics)
Wigner distribution
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Gas distribution
Smell
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Infrared array detectors
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Human-computer interaction
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Nypa palm
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Materials -- Mechanical properties
Metals -- Mechanical properties
Powder metallurgy
Development of silicon nanowire lab-on-chip microfluidics integrated biosensor for low concentration bio-molecules detection
description Lab-on-chip fabricated with one-dimensional nanowires offer excellent electrical properties where bio molecular analysis at very low concentrations is becoming increasingly relevant for medical and research communities. Good number of techniques and promising results has been established for detecting small concentrations; however, for high-throughput measurements and label-free detection are still area of fresh investigation. Many research groups have reported high level of bio recognition by using semiconductor nanowire. The semiconductors silicon nanowire biosensor utilizes a Nano wire between two conducting materials. The nanowire has its atoms concentrated on its surface. Thus, any small changes in the charges present on the nanowire will cause a change in the flow of current. In this thesis, a simulation study coupled with experimental approach to explain the change in wire surface behavior as function of the surface charge. The linear behavior of the conductivity to increase the sensitivity of a semiconducting nanowire biosensor is ascertained. The silicon wire should be between 5 to 20nm to allow mean distance between atoms, the oxide should be as thin as possible for optimum surface integrity, and the functional layer should be thin and have a high dielectric constant. The ionic concentration of the electrolyte should be kept low in order to have a large Debye screening length. To confirm these theoretical results, Silicon nanowire of ≈ 15nm was fabricated using conventional photolithography coupled with dry etching process. To determine the capability of the device, it subjected to various pH values and to achieve this, the device is being operated based on the principle of Field Effect Transistor (FET). The surface of the device is hole dominated (p-type material).
format Thesis
title Development of silicon nanowire lab-on-chip microfluidics integrated biosensor for low concentration bio-molecules detection
title_short Development of silicon nanowire lab-on-chip microfluidics integrated biosensor for low concentration bio-molecules detection
title_full Development of silicon nanowire lab-on-chip microfluidics integrated biosensor for low concentration bio-molecules detection
title_fullStr Development of silicon nanowire lab-on-chip microfluidics integrated biosensor for low concentration bio-molecules detection
title_full_unstemmed Development of silicon nanowire lab-on-chip microfluidics integrated biosensor for low concentration bio-molecules detection
title_sort development of silicon nanowire lab-on-chip microfluidics integrated biosensor for low concentration bio-molecules detection
granting_institution Universiti Malaysia Perlis (UniMAP)
granting_department Institute of Nano Electronic Engineering
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