Intelligent design of microneedle structure for drug delivery system

Transdermal drug delivery (TDD) is an attractive system to transport drugs or biological compounds into human body, for its apparent benefit of eliminating pain and inconvenient intravenous injections. Microneedle is one example of TDD devices that involves various parameters and complex set of des...

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Format:	Thesis
Language:	English
Subjects:	Transdermal medication Drug delivery systems Microneedle Microneedle > Design and construction Transdermal drug delivery (TDD)
Online Access:	http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77063/1/Page%201-24.pdf http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77063/2/Full%20text.pdf http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77063/4/Nur%20Afifah%20Ism.pdf
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id	my-unimap-77063
record_format	uketd_dc
spelling	my-unimap-770632022-11-17T04:24:52Z Intelligent design of microneedle structure for drug delivery system Nurul Izza, Mohd Nor, Dr. Transdermal drug delivery (TDD) is an attractive system to transport drugs or biological compounds into human body, for its apparent benefit of eliminating pain and inconvenient intravenous injections. Microneedle is one example of TDD devices that involves various parameters and complex set of design requirements. Design and analysis of microneedle structure for drug delivery system has been an important issue among researchers especially in biological micro-electro-mechanical system (BioMEMS) field. As MEMS-based microneedles develop in complexity, there is a greater need to reduce the time taken for a MEMS designer to analyze their design before proceed to fabrication process. This study proposed the used of artificial intelligence (AI) methods as a systematic optimization tool to reduce the amount of time taken for designing a microneedle structure. An optimization of microneedle structure is demonstrated by using two techniques of AI which are particle swarm optimization (PSO) and genetic algorithm (GA). A hybrid optimization algorithm has been investigated by combining the PSO with GA to improve computation competency. This combination method is called hybrid PSO-GA (HPSOGA). There are eight design variables of microneedle structure to be optimized in this research. The complex design of microneedle structure considers the shape of microneedle, material used, size of the array, the base of microneedle, the lumen base, the height of microneedle, the height of the lumen, and the height of the drug container or reservoir. Universiti Malaysia Perlis (UniMAP) Thesis en http://dspace.unimap.edu.my:80/xmlui/handle/123456789/77063 http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77063/3/license.txt 8a4605be74aa9ea9d79846c1fba20a33 http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77063/1/Page%201-24.pdf 552b5f44296c4d74758ef0063b8e7fda http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77063/2/Full%20text.pdf e189df948aa920aca71d3d26195db345 http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77063/4/Nur%20Afifah%20Ism.pdf 0cb9f31305d3b37ef2b425d0407bba2b Universiti Malaysia Perlis (UniMAP) Transdermal medication Drug delivery systems Microneedle Microneedle -- Design and construction Transdermal drug delivery (TDD) School of Microelectronic Engineering
institution	Universiti Malaysia Perlis
collection	UniMAP Institutional Repository
language	English
advisor	Nurul Izza, Mohd Nor, Dr.
topic	Transdermal medication Drug delivery systems Microneedle Microneedle -- Design and construction Transdermal drug delivery (TDD)
spellingShingle	Transdermal medication Drug delivery systems Microneedle Microneedle -- Design and construction Transdermal drug delivery (TDD) Intelligent design of microneedle structure for drug delivery system
description	Transdermal drug delivery (TDD) is an attractive system to transport drugs or biological compounds into human body, for its apparent benefit of eliminating pain and inconvenient intravenous injections. Microneedle is one example of TDD devices that involves various parameters and complex set of design requirements. Design and analysis of microneedle structure for drug delivery system has been an important issue among researchers especially in biological micro-electro-mechanical system (BioMEMS) field. As MEMS-based microneedles develop in complexity, there is a greater need to reduce the time taken for a MEMS designer to analyze their design before proceed to fabrication process. This study proposed the used of artificial intelligence (AI) methods as a systematic optimization tool to reduce the amount of time taken for designing a microneedle structure. An optimization of microneedle structure is demonstrated by using two techniques of AI which are particle swarm optimization (PSO) and genetic algorithm (GA). A hybrid optimization algorithm has been investigated by combining the PSO with GA to improve computation competency. This combination method is called hybrid PSO-GA (HPSOGA). There are eight design variables of microneedle structure to be optimized in this research. The complex design of microneedle structure considers the shape of microneedle, material used, size of the array, the base of microneedle, the lumen base, the height of microneedle, the height of the lumen, and the height of the drug container or reservoir.
format	Thesis
title	Intelligent design of microneedle structure for drug delivery system
title_short	Intelligent design of microneedle structure for drug delivery system
title_full	Intelligent design of microneedle structure for drug delivery system
title_fullStr	Intelligent design of microneedle structure for drug delivery system
title_full_unstemmed	Intelligent design of microneedle structure for drug delivery system
title_sort	intelligent design of microneedle structure for drug delivery system
granting_institution	Universiti Malaysia Perlis (UniMAP)
granting_department	School of Microelectronic Engineering
url	http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77063/1/Page%201-24.pdf http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77063/2/Full%20text.pdf http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77063/4/Nur%20Afifah%20Ism.pdf
_version_	1776104231326973952

Intelligent design of microneedle structure for drug delivery system

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