Arterial fluid flow investigation on double stenoses contact morphology for medical application

Fluid flow investigation has been constantly worked upon since the dawn of Microelectromechanical Systems (MEMS) devices. Human vascular system provides the means for MEMS transportation thus enabling study and analysis on human diseases. Atherosclerosis is a vascular disease characterized by depos...

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Format:	Thesis
Language:	English
Subjects:	Blood-vessels Stenosis Arteries > Stenosis Atherosclerosis Cardiovascular system Microelectromechanical systems
Online Access:	http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77086/1/Page%201-24.pdf http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77086/2/Full%20text.pdf http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77086/4/Nor%20Shakirina.pdf
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spelling	my-unimap-770862022-11-17T07:44:16Z Arterial fluid flow investigation on double stenoses contact morphology for medical application Vithyacharan, Retnasamy, Dr. Fluid flow investigation has been constantly worked upon since the dawn of Microelectromechanical Systems (MEMS) devices. Human vascular system provides the means for MEMS transportation thus enabling study and analysis on human diseases. Atherosclerosis is a vascular disease characterized by deposition of plaques on the arterial wall. The progression of atherosclerotic plaques may cause serious consequences due to disturbance of the blood flow such as heart attack and stroke. Therefore, the study of the fluid dynamics in the stenosed artery bears important aspects to predict the development of atherosclerosis. In this research, the Newtonian fluid through double stenoses has been investigated using Ansys CFX software. To study the effects of stenosis morphology, three different geometries have been used; cosineshaped, irregular shape and protruding shape. These geometries present different area occlusion but similar configurations of stricture length and height. On the other hand, the effects of restriction spacing have been explored by varying the distance between the double stenoses without changing the size of each stenosis. The effects of Reynolds numbers have been investigated as well in the range of 100 to 400 based on human physiological flow. Hemodynamic characteristics of blood flow such as velocity profiles, wall pressure and wall shear stress distributions have been performed for all cases. The results demonstrate highest peak velocity, pressure drop and peak wall shear stress with the value of 0.7518 ms-1, 398.16 Nm-2 and 15.39 Nm-2 respectively for the case of double irregular stenoses. It is interesting to find out that double protrudingshaped stenoses exhibit greater peak velocity (0.672 ms-1) and peak wall shear stress (14.90 Nm-2) in comparison with cosine-shaped stenosis with peak velocity, 0.6578 ms-1 and peak wall shear stress, 13.06 Nm-2 although the area occlusion of cosine shaped is larger instead. These findings indicate that the severity of the stenosis is primarily caused by the morphology of the stenosis rather than percentage of diameter reduction criterion or effects of area occlusion. Analysis on the effects of restriction spacing shows that the distance between a couple of stenoses has a considerable influence on the velocity profile, wall pressure distribution and wall shear stress variation. In addition, the effects of Reynolds numbers are noticeable in changing the flow pattern near the stenotic region whereby the higher Reynolds numbers increase the size of recirculation zone. The recirculation zones usually occur in the severe stenosed artery. In conclusion, the present study shows that the blood flow characteristics through double stenoses are strongly influenced by the stenosis morphology, restriction spacing and Reynolds numbers Universiti Malaysia Perlis (UniMAP) Thesis en http://dspace.unimap.edu.my:80/xmlui/handle/123456789/77086 http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77086/3/license.txt 8a4605be74aa9ea9d79846c1fba20a33 http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77086/1/Page%201-24.pdf 787e561b28328094eacf2dc9e451f7e1 http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77086/2/Full%20text.pdf fa6824d69031d8a23081802451c0de98 http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77086/4/Nor%20Shakirina.pdf 662a9d714a6dae0e2d9cc7e7a222cdc5 Universiti Malaysia Perlis (UniMAP) Blood-vessels Stenosis Arteries -- Stenosis Atherosclerosis Cardiovascular system Microelectromechanical systems School of Microelectronic Engineering
institution	Universiti Malaysia Perlis
collection	UniMAP Institutional Repository
language	English
advisor	Vithyacharan, Retnasamy, Dr.
topic	Blood-vessels Stenosis Arteries -- Stenosis Atherosclerosis Cardiovascular system Microelectromechanical systems
spellingShingle	Blood-vessels Stenosis Arteries -- Stenosis Atherosclerosis Cardiovascular system Microelectromechanical systems Arterial fluid flow investigation on double stenoses contact morphology for medical application
description	Fluid flow investigation has been constantly worked upon since the dawn of Microelectromechanical Systems (MEMS) devices. Human vascular system provides the means for MEMS transportation thus enabling study and analysis on human diseases. Atherosclerosis is a vascular disease characterized by deposition of plaques on the arterial wall. The progression of atherosclerotic plaques may cause serious consequences due to disturbance of the blood flow such as heart attack and stroke. Therefore, the study of the fluid dynamics in the stenosed artery bears important aspects to predict the development of atherosclerosis. In this research, the Newtonian fluid through double stenoses has been investigated using Ansys CFX software. To study the effects of stenosis morphology, three different geometries have been used; cosineshaped, irregular shape and protruding shape. These geometries present different area occlusion but similar configurations of stricture length and height. On the other hand, the effects of restriction spacing have been explored by varying the distance between the double stenoses without changing the size of each stenosis. The effects of Reynolds numbers have been investigated as well in the range of 100 to 400 based on human physiological flow. Hemodynamic characteristics of blood flow such as velocity profiles, wall pressure and wall shear stress distributions have been performed for all cases. The results demonstrate highest peak velocity, pressure drop and peak wall shear stress with the value of 0.7518 ms-1, 398.16 Nm-2 and 15.39 Nm-2 respectively for the case of double irregular stenoses. It is interesting to find out that double protrudingshaped stenoses exhibit greater peak velocity (0.672 ms-1) and peak wall shear stress (14.90 Nm-2) in comparison with cosine-shaped stenosis with peak velocity, 0.6578 ms-1 and peak wall shear stress, 13.06 Nm-2 although the area occlusion of cosine shaped is larger instead. These findings indicate that the severity of the stenosis is primarily caused by the morphology of the stenosis rather than percentage of diameter reduction criterion or effects of area occlusion. Analysis on the effects of restriction spacing shows that the distance between a couple of stenoses has a considerable influence on the velocity profile, wall pressure distribution and wall shear stress variation. In addition, the effects of Reynolds numbers are noticeable in changing the flow pattern near the stenotic region whereby the higher Reynolds numbers increase the size of recirculation zone. The recirculation zones usually occur in the severe stenosed artery. In conclusion, the present study shows that the blood flow characteristics through double stenoses are strongly influenced by the stenosis morphology, restriction spacing and Reynolds numbers
format	Thesis
title	Arterial fluid flow investigation on double stenoses contact morphology for medical application
title_short	Arterial fluid flow investigation on double stenoses contact morphology for medical application
title_full	Arterial fluid flow investigation on double stenoses contact morphology for medical application
title_fullStr	Arterial fluid flow investigation on double stenoses contact morphology for medical application
title_full_unstemmed	Arterial fluid flow investigation on double stenoses contact morphology for medical application
title_sort	arterial fluid flow investigation on double stenoses contact morphology for medical application
granting_institution	Universiti Malaysia Perlis (UniMAP)
granting_department	School of Microelectronic Engineering
url	http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77086/1/Page%201-24.pdf http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77086/2/Full%20text.pdf http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77086/4/Nor%20Shakirina.pdf
_version_	1776104244496039936

Arterial fluid flow investigation on double stenoses contact morphology for medical application

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