Gene expression study on tumour suppressor gene rassfi isoforms and selected inflammatory cytokines in bladder carcinoma
Bladder carcinoma (BC) arises as a result of deregulation in oncogene and tumor suppressor gene. Loss of heterozygosity at chromosome region 3p has become common in most cancer development. A tumour suppessor gene, RASSF1 located at this particular egion has been reported to be hypermethylated in mo...
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| Main Author: | |
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| Format: | Thesis |
| Language: | English |
| Published: |
2011
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/11816/1/Nur%20Diana%20Anuar%20ft.pdf |
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| Summary: | Bladder carcinoma (BC) arises as a result of deregulation in oncogene and tumor suppressor gene. Loss of heterozygosity at chromosome region 3p has become common in most cancer development. A tumour suppessor gene, RASSF1 located at this particular egion has been reported to be hypermethylated in most cancer including the bladder and has been a major targeted for tumour suppressor. However, this gene has known to have 7 alternative isoforms which might have different function in bladder tumourigenicity. In this study we aimed to explore the expression status of RASSF1 isofoms in BC biopsy as an effort to explore its role in BC progression. |
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