Expression patterns of markers of inflammation, endothelial dysfunction and platelet activation in early phase of acute coronary syndrome

Inflammation, endothelial dysfunction and platelet activation play an important role in pathogenesis of vulnerable plaques of acute coronary syndrome (ACS). However little is known about the inter-relation of these in early phase of ACS. This study sought to determine a possible multimarker strategy...

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Main Author:	Tiong, Wen Ni.
Format:	Thesis
Language:	English
Published:	2012
Subjects:	RB Pathology
Online Access:	http://ir.unimas.my/id/eprint/11818/2/Wen%20Ni%28fulltext%29.pdf
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id	my-unimas-ir.11818
record_format	uketd_dc
spelling	my-unimas-ir.118182023-05-03T08:38:31Z Expression patterns of markers of inflammation, endothelial dysfunction and platelet activation in early phase of acute coronary syndrome 2012 Tiong, Wen Ni. RB Pathology Inflammation, endothelial dysfunction and platelet activation play an important role in pathogenesis of vulnerable plaques of acute coronary syndrome (ACS). However little is known about the inter-relation of these in early phase of ACS. This study sought to determine a possible multimarker strategy by linking three indices to provide an early assessment of the risk of ACS. Serum protein and gene expression level of interleukin-6 (IL6;biomarker of inflammation), von willebrand Factor (VWF; biomarker of endothelial dysfunction) and soluble P-selectin (SELP; biomarker of platelet activation) were measured in 22 patients with ACS (age 55.2+10.4 years) and 28 controls with angiographically documented occlusive coronary atery disease (CAD) without previous ACS events (age 53.5+8.4 years). Universiti Malaysia Sarawak, (UNIMAS) 2012 Thesis http://ir.unimas.my/id/eprint/11818/ http://ir.unimas.my/id/eprint/11818/2/Wen%20Ni%28fulltext%29.pdf text en validuser masters Universiti Malaysia Sarawak, (UNIMAS) Faculty of Resources Science and Technology
institution	Universiti Malaysia Sarawak
collection	UNIMAS Institutional Repository
language	English
topic	RB Pathology
spellingShingle	RB Pathology Tiong, Wen Ni. Expression patterns of markers of inflammation, endothelial dysfunction and platelet activation in early phase of acute coronary syndrome
description	Inflammation, endothelial dysfunction and platelet activation play an important role in pathogenesis of vulnerable plaques of acute coronary syndrome (ACS). However little is known about the inter-relation of these in early phase of ACS. This study sought to determine a possible multimarker strategy by linking three indices to provide an early assessment of the risk of ACS. Serum protein and gene expression level of interleukin-6 (IL6;biomarker of inflammation), von willebrand Factor (VWF; biomarker of endothelial dysfunction) and soluble P-selectin (SELP; biomarker of platelet activation) were measured in 22 patients with ACS (age 55.2+10.4 years) and 28 controls with angiographically documented occlusive coronary atery disease (CAD) without previous ACS events (age 53.5+8.4 years).
format	Thesis
qualification_level	Master's degree
author	Tiong, Wen Ni.
author_facet	Tiong, Wen Ni.
author_sort	Tiong, Wen Ni.
title	Expression patterns of markers of inflammation, endothelial dysfunction and platelet activation in early phase of acute coronary syndrome
title_short	Expression patterns of markers of inflammation, endothelial dysfunction and platelet activation in early phase of acute coronary syndrome
title_full	Expression patterns of markers of inflammation, endothelial dysfunction and platelet activation in early phase of acute coronary syndrome
title_fullStr	Expression patterns of markers of inflammation, endothelial dysfunction and platelet activation in early phase of acute coronary syndrome
title_full_unstemmed	Expression patterns of markers of inflammation, endothelial dysfunction and platelet activation in early phase of acute coronary syndrome
title_sort	expression patterns of markers of inflammation, endothelial dysfunction and platelet activation in early phase of acute coronary syndrome
granting_institution	Universiti Malaysia Sarawak, (UNIMAS)
granting_department	Faculty of Resources Science and Technology
publishDate	2012
url	http://ir.unimas.my/id/eprint/11818/2/Wen%20Ni%28fulltext%29.pdf
_version_	1783728099341369344

Expression patterns of markers of inflammation, endothelial dysfunction and platelet activation in early phase of acute coronary syndrome

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