Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections

All flaviviruses share common epitopes on the envelope protein (E) that results in extensive crossreactions in serological tests. /this makes it difficult to distinguish between immune responses against dengue virus (DENV) and Japanese encephalitis virus (JEV), particularly in regions where these vi...

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Main Author: Wang, Seok Mui
Format: Thesis
Language:English
Published: 2001
Subjects:
Online Access:http://ir.unimas.my/id/eprint/16585/1/Wong%20Seok%20ft.pdf
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spelling my-unimas-ir.165852023-11-21T05:21:20Z Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections 2001 Wang, Seok Mui RA Public aspects of medicine All flaviviruses share common epitopes on the envelope protein (E) that results in extensive crossreactions in serological tests. /this makes it difficult to distinguish between immune responses against dengue virus (DENV) and Japanese encephalitis virus (JEV), particularly in regions where these viruses co-circulate. We have demonstrated that DENV and JEV have unique epitopes on the prM. By detecting prM specific IgG, it is possible to distinguish between DENV and JEV infection. Current approach used in seroanalysis of DENV and JEV infections is based on antigens derived from the whole viral antigens. 2001 Thesis http://ir.unimas.my/id/eprint/16585/ http://ir.unimas.my/id/eprint/16585/1/Wong%20Seok%20ft.pdf text en validuser masters Universiti Malaysia Sarawak, (UNIMAS) Institute of Health and Community Medicine.
institution Universiti Malaysia Sarawak
collection UNIMAS Institutional Repository
language English
topic RA Public aspects of medicine
spellingShingle RA Public aspects of medicine
Wang, Seok Mui
Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections
description All flaviviruses share common epitopes on the envelope protein (E) that results in extensive crossreactions in serological tests. /this makes it difficult to distinguish between immune responses against dengue virus (DENV) and Japanese encephalitis virus (JEV), particularly in regions where these viruses co-circulate. We have demonstrated that DENV and JEV have unique epitopes on the prM. By detecting prM specific IgG, it is possible to distinguish between DENV and JEV infection. Current approach used in seroanalysis of DENV and JEV infections is based on antigens derived from the whole viral antigens.
format Thesis
qualification_level Master's degree
author Wang, Seok Mui
author_facet Wang, Seok Mui
author_sort Wang, Seok Mui
title Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections
title_short Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections
title_full Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections
title_fullStr Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections
title_full_unstemmed Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections
title_sort cloning and expression of prm and it's use to distinguish host immune responses against dengue virus and japanese encephalitis virus infections
granting_institution Universiti Malaysia Sarawak, (UNIMAS)
granting_department Institute of Health and Community Medicine.
publishDate 2001
url http://ir.unimas.my/id/eprint/16585/1/Wong%20Seok%20ft.pdf
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