Synthesis of Kojic Acid Derivatives and their Applications
The development of potential value-added product derived from agriculture waste has become an attractive study among researchers. In this research, kojic acid 1 was successfully obtained via fermentation of sago waste as support-substrates, followed by series of chemical modification destined for...
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my-unimas-ir.209712024-04-24T08:00:39Z Synthesis of Kojic Acid Derivatives and their Applications 2017 Sie, Carolynne Zie Wei Q Science (General) QD Chemistry The development of potential value-added product derived from agriculture waste has become an attractive study among researchers. In this research, kojic acid 1 was successfully obtained via fermentation of sago waste as support-substrates, followed by series of chemical modification destined for biological and electrical applications. For biological application, a series of novel kojic acid-chalcone derivatives 40a-c has been successfully synthesized from the reaction of 1 prepared from sago waste with carboxyl chalcone 39a-c via Steglich esterification. Carboxyl chalcone 39a-c, which was prior prepared via Claisen Schmidt Condensation, showed active inhibition against Staphylococcus aureus with 39c gave the best inhibition of 8 mm. The incorporation of 1 into 39a-c, 40a-c gave a reverse antibacterial trend where 40a exhibited excellent zone of inhibition (8 mm) compared to ampicillin (11 mm). Novel kojic acid–azobenzene ester derivatives 49a-e bearing different vinyl chain lengths were also successfully synthesized via kojyl chloride 51 with azobenzene molecules. unimas 2017 Thesis http://ir.unimas.my/id/eprint/20971/ http://ir.unimas.my/id/eprint/20971/1/Carolynne%20ft.pdf text en validuser phd doctoral UNIMAS |
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Universiti Malaysia Sarawak |
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English |
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Q Science (General) QD Chemistry |
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Q Science (General) QD Chemistry Sie, Carolynne Zie Wei Synthesis of Kojic Acid Derivatives and their Applications |
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The development of potential value-added product derived from agriculture waste has become an attractive study among researchers. In this research, kojic acid 1 was successfully obtained via fermentation of sago waste as support-substrates, followed by series of chemical
modification destined for biological and electrical applications. For biological application, a series of novel kojic acid-chalcone derivatives 40a-c has been successfully synthesized from the reaction of 1 prepared from sago waste with carboxyl chalcone 39a-c via Steglich esterification. Carboxyl chalcone 39a-c, which was prior prepared via Claisen Schmidt Condensation, showed active inhibition against Staphylococcus aureus with 39c gave the best
inhibition of 8 mm. The incorporation of 1 into 39a-c, 40a-c gave a reverse antibacterial trend where 40a exhibited excellent zone of inhibition (8 mm) compared to ampicillin (11 mm). Novel kojic acid–azobenzene ester derivatives 49a-e bearing different vinyl chain lengths
were also successfully synthesized via kojyl chloride 51 with azobenzene molecules. |
format |
Thesis |
qualification_name |
Doctor of Philosophy (PhD.) |
qualification_level |
Doctorate |
author |
Sie, Carolynne Zie Wei |
author_facet |
Sie, Carolynne Zie Wei |
author_sort |
Sie, Carolynne Zie Wei |
title |
Synthesis of Kojic Acid Derivatives and their Applications |
title_short |
Synthesis of Kojic Acid Derivatives and their Applications |
title_full |
Synthesis of Kojic Acid Derivatives and their Applications |
title_fullStr |
Synthesis of Kojic Acid Derivatives and their Applications |
title_full_unstemmed |
Synthesis of Kojic Acid Derivatives and their Applications |
title_sort |
synthesis of kojic acid derivatives and their applications |
granting_institution |
UNIMAS |
publishDate |
2017 |
url |
http://ir.unimas.my/id/eprint/20971/1/Carolynne%20ft.pdf |
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1804888390653444096 |