Synthesis and Characterization of Multifunctional Nanostructures Derived from Native Sago Starch for Potential Biomedical Applications

This study reports the potential application of hydroxypropyl starch and starch acetate nanoparticles as a controlled release nanocarrier for piperine. Hydroxypropyl starch and starch acetate were synthesized by modifying sago starch with hydroxypropylation and acetylation reaction. Hydroxypropyl st...

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Main Author:	Asniar, Salim
Format:	Thesis
Language:	English
Published:	2020
Subjects:	QD Chemistry
Online Access:	http://ir.unimas.my/id/eprint/33150/1/Asniar%20Binti%20Salim%20ft.pdf
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spelling	my-unimas-ir.331502023-03-06T06:17:06Z Synthesis and Characterization of Multifunctional Nanostructures Derived from Native Sago Starch for Potential Biomedical Applications 2020-04-01 Asniar, Salim QD Chemistry This study reports the potential application of hydroxypropyl starch and starch acetate nanoparticles as a controlled release nanocarrier for piperine. Hydroxypropyl starch and starch acetate were synthesized by modifying sago starch with hydroxypropylation and acetylation reaction. Hydroxypropyl starch nanoparticles with mean particle sizes of 110 nm were obtained by controlled precipitation through drop-wise addition of dissolved hydroxypropyl starch solution into excess absolute ethanol. Meanwhile, starch acetate with mean particle sizes of 140 nm was also successfully obtained by the same manner. Piperine was loaded onto hydroxypropyl starch nanoparticles, starch acetate nanoparticles, and native starch nanoparticles via the in-situ nanoprecipitation process. Hydroxypropyl starch nanoparticles and starch acetate nanoparticles achieved higher piperine loading capacity as compared to native starch nanoparticles with the maximum loading capacity of 0.46, 0.50, and 0.33 mg.mg-1, respectively. Hydroxypropyl starch nanoparticles was able to retain piperine in the simulated stomach pH (1.2) where it was released in a slow and sustained manner within 24 hours, while piperine was release from starch acetate nanoparticles over a period of 28 hours in the simulated blood pH (7.4). On the other hand, the release rates of piperine from native starch nanoparticles were faster, whereby 96% of piperine was released within 16 hours at all pH tested in the same manner. Universiti Malaysia Sarawak (UNIMAS) 2020-04 Thesis http://ir.unimas.my/id/eprint/33150/ http://ir.unimas.my/id/eprint/33150/1/Asniar%20Binti%20Salim%20ft.pdf text en validuser https://jns.kashanu.ac.ir/issue_14232_14457.html masters Universiti Malaysia Sarawak Faculty of Resource Science and Technology Tun Openg Chair (F07/ TOC/1511/2016) Ackar, D., Babic, J., Jozinovic, A., Jokic, S., Milicevic, R.,Rajic, M., & Subaric, D. (2015). Starch modification by organic acids and their derivatives: A review. Journal of Molecules, 20, 19554–19570. Assaad, E., & Mateescu, M. A. (2010). The influence of protonantion ratio on properties of carboxymethyl starch excipient at various substitution degrees: Structural insights and drug release kinetics. International Journal of Pharmaceutics, 394(1-2), 75-84. Aminian, M., Nafchi, A. M., Bolandi, M., & Alias, A. K. (2013). Preparation and characterization of high degree substituted sago (Metroxylon sagu) starch with propylene oxide. Starch, 65, 686–693. Badakshanian, E., Hemmati, K., & Ghaemy, M. (2016). Enhancement of mechanical properties of nanohydrogels based on natural gum with functionalized multiwall carbon nanotube: Study of swelling and drug release. Polymer, 90, 282-289. Bartz, J., Tiago, J., Antônio, M., Zavareze, R., Artigas, M., Renato, A., & Dias, G. (2015). Acetylation of barnyardgrass starch with acetic anhydride under iodine catalysis. Food Chemistry, 178, 236–242. Baspinar, Y., Üstündas, M., Bayraktar, O., & Sezgin, C. (2018). Curcumin and piperine loaded zein-chitosan nanoparticles: Development and in-vitro characterisation. Saudi Pharmaceutical Journal, 26(3), 323-334. Bemiller, J. N., & Huber, K. C. (2015). Physical modification of food starch functionalities. Annual Review of Food Science and Technology, 6, 19-69.
institution	Universiti Malaysia Sarawak
collection	UNIMAS Institutional Repository
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Asniar, Salim Synthesis and Characterization of Multifunctional Nanostructures Derived from Native Sago Starch for Potential Biomedical Applications
description	This study reports the potential application of hydroxypropyl starch and starch acetate nanoparticles as a controlled release nanocarrier for piperine. Hydroxypropyl starch and starch acetate were synthesized by modifying sago starch with hydroxypropylation and acetylation reaction. Hydroxypropyl starch nanoparticles with mean particle sizes of 110 nm were obtained by controlled precipitation through drop-wise addition of dissolved hydroxypropyl starch solution into excess absolute ethanol. Meanwhile, starch acetate with mean particle sizes of 140 nm was also successfully obtained by the same manner. Piperine was loaded onto hydroxypropyl starch nanoparticles, starch acetate nanoparticles, and native starch nanoparticles via the in-situ nanoprecipitation process. Hydroxypropyl starch nanoparticles and starch acetate nanoparticles achieved higher piperine loading capacity as compared to native starch nanoparticles with the maximum loading capacity of 0.46, 0.50, and 0.33 mg.mg-1, respectively. Hydroxypropyl starch nanoparticles was able to retain piperine in the simulated stomach pH (1.2) where it was released in a slow and sustained manner within 24 hours, while piperine was release from starch acetate nanoparticles over a period of 28 hours in the simulated blood pH (7.4). On the other hand, the release rates of piperine from native starch nanoparticles were faster, whereby 96% of piperine was released within 16 hours at all pH tested in the same manner.
format	Thesis
qualification_level	Master's degree
author	Asniar, Salim
author_facet	Asniar, Salim
author_sort	Asniar, Salim
title	Synthesis and Characterization of Multifunctional Nanostructures Derived from Native Sago Starch for Potential Biomedical Applications
title_short	Synthesis and Characterization of Multifunctional Nanostructures Derived from Native Sago Starch for Potential Biomedical Applications
title_full	Synthesis and Characterization of Multifunctional Nanostructures Derived from Native Sago Starch for Potential Biomedical Applications
title_fullStr	Synthesis and Characterization of Multifunctional Nanostructures Derived from Native Sago Starch for Potential Biomedical Applications
title_full_unstemmed	Synthesis and Characterization of Multifunctional Nanostructures Derived from Native Sago Starch for Potential Biomedical Applications
title_sort	synthesis and characterization of multifunctional nanostructures derived from native sago starch for potential biomedical applications
granting_institution	Universiti Malaysia Sarawak
granting_department	Faculty of Resource Science and Technology
publishDate	2020
url	http://ir.unimas.my/id/eprint/33150/1/Asniar%20Binti%20Salim%20ft.pdf
_version_	1783728423391199232

Synthesis and Characterization of Multifunctional Nanostructures Derived from Native Sago Starch for Potential Biomedical Applications

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