Enantioselective Esterification Of (±)-Menthol With Butyric Anhydride By Chemically Modified Candida Rugosa Lipase

Commercial lipase from Candida rugosa was chemically modified with the aim to improve its catalytic properties in organic solvents. The chemical modifiers, aldehydes and monomethoxy polyethylene glycols, were covalently linked to the lysine residues at the surface of the enzyme. Enzymatic enantio...

Full description

Saved in:

Bibliographic Details
Main Author:	Jasmani, Halila
Format:	Thesis
Language:	English English
Published:	2003
Subjects:	Enantioselective catalysis Lipase Esterification
Online Access:	http://psasir.upm.edu.my/id/eprint/11622/1/FSAS_2003_10.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-upm-ir.11622
record_format	uketd_dc
spelling	my-upm-ir.116222024-06-24T03:31:53Z Enantioselective Esterification Of (±)-Menthol With Butyric Anhydride By Chemically Modified Candida Rugosa Lipase 2003-05 Jasmani, Halila Commercial lipase from Candida rugosa was chemically modified with the aim to improve its catalytic properties in organic solvents. The chemical modifiers, aldehydes and monomethoxy polyethylene glycols, were covalently linked to the lysine residues at the surface of the enzyme. Enzymatic enantioselective esterification of racemic menthol in organic solvents using butyric anhydride as acylating agent was performed with the chemically modified lipases. Different degrees of modification, organic solvents, reaction temperatures and water activity were examined for the influence on the percent yield and enantioselective formation of (-)-menthyl butyrate. The percent yield increased as the degree of modification increased but decreased slightly for the highest degree of modification. Organic solvents with log P values above 2.5 gave higher yield, however high enantioselectivity was obtained in all the organic solvents tested. The enantioselectivity towards (-)-menthol decreased considerably as the reaction temperature was increased. Enzyme derivatives exhibited better activity and enantioselectivity at high aw. The alkylated lipases showed higher thermal, solvent Enantioselective catalysis Lipase Esterification 2003-05 Thesis http://psasir.upm.edu.my/id/eprint/11622/ http://psasir.upm.edu.my/id/eprint/11622/1/FSAS_2003_10.pdf text en public masters Universiti Putra Malaysia Enantioselective catalysis Lipase Esterification Faculty of Environmental studies Salleh, Abu Bakar English
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English English
advisor	Salleh, Abu Bakar
topic	Enantioselective catalysis Lipase Esterification
spellingShingle	Enantioselective catalysis Lipase Esterification Jasmani, Halila Enantioselective Esterification Of (±)-Menthol With Butyric Anhydride By Chemically Modified Candida Rugosa Lipase
description	Commercial lipase from Candida rugosa was chemically modified with the aim to improve its catalytic properties in organic solvents. The chemical modifiers, aldehydes and monomethoxy polyethylene glycols, were covalently linked to the lysine residues at the surface of the enzyme. Enzymatic enantioselective esterification of racemic menthol in organic solvents using butyric anhydride as acylating agent was performed with the chemically modified lipases. Different degrees of modification, organic solvents, reaction temperatures and water activity were examined for the influence on the percent yield and enantioselective formation of (-)-menthyl butyrate. The percent yield increased as the degree of modification increased but decreased slightly for the highest degree of modification. Organic solvents with log P values above 2.5 gave higher yield, however high enantioselectivity was obtained in all the organic solvents tested. The enantioselectivity towards (-)-menthol decreased considerably as the reaction temperature was increased. Enzyme derivatives exhibited better activity and enantioselectivity at high aw. The alkylated lipases showed higher thermal, solvent
format	Thesis
qualification_level	Master's degree
author	Jasmani, Halila
author_facet	Jasmani, Halila
author_sort	Jasmani, Halila
title	Enantioselective Esterification Of (±)-Menthol With Butyric Anhydride By Chemically Modified Candida Rugosa Lipase
title_short	Enantioselective Esterification Of (±)-Menthol With Butyric Anhydride By Chemically Modified Candida Rugosa Lipase
title_full	Enantioselective Esterification Of (±)-Menthol With Butyric Anhydride By Chemically Modified Candida Rugosa Lipase
title_fullStr	Enantioselective Esterification Of (±)-Menthol With Butyric Anhydride By Chemically Modified Candida Rugosa Lipase
title_full_unstemmed	Enantioselective Esterification Of (±)-Menthol With Butyric Anhydride By Chemically Modified Candida Rugosa Lipase
title_sort	enantioselective esterification of (±)-menthol with butyric anhydride by chemically modified candida rugosa lipase
granting_institution	Universiti Putra Malaysia
granting_department	Faculty of Environmental studies
publishDate	2003
url	http://psasir.upm.edu.my/id/eprint/11622/1/FSAS_2003_10.pdf
_version_	1804888642937683968

Enantioselective Esterification Of (±)-Menthol With Butyric Anhydride By Chemically Modified Candida Rugosa Lipase

Similar Items