Pharmacokinetics Of Imidocarb In Normal And Febrile Dogs And Goats
Disposition kinetics of imidocarb , an antiprotozoan drug, was studied in normal and febrile dog sand goats . Fever was induced using E. coli endotoxin , Trypanosoma evansi and Infectious Bovine Rhinotracheitis (I BR) virus.The objectives of the study were to compare the disposition kinetics of...
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| Format: | Thesis |
| Language: | English English |
| Published: |
1983
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| Subjects: | |
| Online Access: | http://psasir.upm.edu.my/id/eprint/11739/1/FPV_1983_7.pdf |
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| Summary: | Disposition kinetics of imidocarb , an antiprotozoan drug,
was studied in normal and febrile dog sand goats . Fever was
induced using E. coli endotoxin , Trypanosoma evansi and Infectious
Bovine Rhinotracheitis (I BR) virus.The objectives of the study
were to compare the disposition kinetics of imidocarb in ruminant
and monogastrics pecies , and the influence of fever of different
etiology on the disposition kinetics of this drug. The concentration of imidocarb in body fluids and tissues were measured by
spectrophotometry.The disposition kinetics of imidocarb in normal and febrile
dogs and goats can be adequately described by a two-compartment
open model. The apparent volume of the central compartment , V,c
was significantly lower (P<0.01) but the volume of distribution,
V d(area) was significantly higher (P<0.05) in normal goats than
in dogs.Higher volume of distribution and the ratio of imidocarb
level in peripheral- to-central compartment in goats ( 6:1 )
prolonged elimination of the drug, resulting in considerably
higher levels of the drug still present in the tissues 14 days
after a single subcutaneous or intramuscular dose. |
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